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390-420 / 1000+ resultscommunity 5 alpha reductase type 1 is in brain tissue producing the main endogenous gabaergic allopregnanolone, not 2. How can finasteride as a 5ar2 lower that?
Finasteride and dutasteride are discussed for hair loss, with concerns about their effects on neurosteroids and potential side effects like depression. Alternatives like topical estrogen and lifestyle changes are considered, with varying opinions on mental health and hair regrowth.
community Bloodwork after 18 months on finasteride (1 year on dut + fin)
The user has been on finasteride for 18 months and added dutasteride after the first 6 months, with no hair regrowth observed. Bloodwork shows normal levels of DHT despite the use of both medications.
community What should I include in my blood test?
The user has been using finasteride, dutasteride, and minoxidil without success and is considering a comprehensive blood test to explore other causes of hair loss. They are unsure about the necessity and cost of the extensive tests and are seeking advice on whether to proceed with the full panel or focus on specific tests.
community Do hair follicles dies or are dormant ?
Hair follicles can be dormant and potentially revived with treatments like finasteride and minoxidil, but irreversible loss occurs if certain structures are destroyed. Early intervention is more effective, and additional methods like microneedling may help.
community 11 Months Pantostin / 3 Months 25mg CPA
The user is asking for opinions on whether their hair growth is due to Pantostin and hormone treatments. One commenter confirms regrowth and asks about the hormone treatments.
community 2 months and 2 weeks on topical dutasteride + minoxidil
community What a difference some fin and dermarolling make. Ty Tressless
The conversation discusses the positive impact of finasteride and dermarolling on hair loss. The topic is categorized under "Progress Pictures", highlighting the noticeable difference these treatments have made.
community I built a tracker for every hair loss treatment in clinical development
A user created a tracker for hair loss treatments in clinical development, including compounds like Dermaliq, RU58841, and Pyrilutamide. The tracker updates with new information and allows filtering by conditions like androgenetic alopecia (AGA) and alopecia areata (AA).
community new way to activate stem cells to make hair grow
Stem cell-related treatments and drugs like RCGD423 and WAY are being tested for hair growth. Clinics are conducting tests on patients who haven't had previous treatments.
community IS this thinning or my hair swirl/parting?
The conversation discusses hair thinning and treatments like Minoxidil, finasteride, and RU58841. The user is concerned about distinguishing between natural hair parting and actual thinning.
community If half life of fin is 6-8 hours in the blood but 5-6 days in tissue (scalp) why don't people apply topical every 3-4 days to minimize systemic?
The discussion revolves around the frequency of applying topical finasteride for hair loss treatment. The main question is whether applying it every 4-5 days could still be effective, given that its half-life in the scalp tissue is 5-6 days.
community Which labs / blood baseline markers to check before beginning treatment?
The conversation is about which blood tests are essential to check before starting hair loss treatment with finasteride or dutasteride. The tests mentioned include DHT, PSA, Estrogen/Estradiol, Testosterone, FSH, and LH.
community there's some improvement here?
A user shared their hair loss journey, showing improvement after starting finasteride, dutasteride, minoxidil 5%, and microneedling. They are curious about their degree of baldness and why their hair has thinned.
community any news about DUPA (Diffuse unpatterned alopecia)?
The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.
community MBP Itch CURE?/ Slow shedding TBD
A user with diffuse hair loss for a decade tried various treatments, including LLLT Helmet, supplements, topicals, and hair transplants. They found relief from scalp inflammation and itching using a topical solution made from crushed Xeljanz pills mixed with ethyl alcohol.
community Which markers and nutrients could contribute to hair health in context of checking for deficiencies?
Hair loss is primarily genetic, and nutrient deficiencies are unlikely to be the cause. DHT inhibitors can slow hair loss, but concerns about side effects are common.
community DHT Harms Scalp Microbiome: DHT Itch is REAL
Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.
community Ultimate DHT/finasteride microdosing graph to replace the commonly one referenced on forums
Hair loss treatments, specifically, discussing the effectiveness and side effects of finasteride, minoxidil, and RU58841 in various microdoses. It also includes an updated graph which provides information on how different doses affect DHT levels, scalp skin and serum androgen levels, as well as hair count.
community The Effect of Intradermal Botox on Androgenetic Alopecia and Its Possible Mechanism (Journal of the American Academy of Dermatology (2020)
Intradermal botulinum toxin (BTX) injections effectively treat androgenetic alopecia (AGA) by inhibiting TGF-β1 secretion from hair follicles. Further research and long-term follow-up are needed to confirm these findings.
community Dogan Turan vs Bruno Pinto please i need your suggested
The user is considering a hair transplant and is using topical finasteride, minoxidil, antiandrogens, ketoconazole shampoo, and serenoa repens. They are deciding between surgeons Dogan Turan and Bruno Pinto, and are concerned about the technique and potential complications due to diffuse hair loss.
community progress pics (HRT, fin, min, microneedling) (35, trans non-binary)
A non-binary transfeminine person experienced significant hair regrowth after starting finasteride, minoxidil, microneedling, and hormone replacement therapy with estradiol. They encourage trans individuals concerned about hair loss to consider estrogen as it has greatly improved their hair condition.
community HRT temple regrowth - 0 months, 3 months, 6 months
community Miniaturized hair or regrowth?
A user started finasteride a month ago and is unsure if small hairs are miniaturized or new growth. Replies include a joke and a deleted comment.
community A flowchart showing how dermatologists treat male-pattern baldness from UpToDate, the industry-standard reference
Dermatologists use treatments like oral minoxidil, finasteride, and RU58841 for male-pattern baldness, considering side effects and patient preferences. Photobiomodulation is noted as mildly effective but costly, while PRP is debated for its effectiveness compared to microneedling.
community My topical finasteride DHT test results (before and after)
A user shared their experience using topical finasteride for 6 months, showing a reduction in DHT levels but no visible improvement in hair loss. They are considering switching to oral finasteride for potentially better results.
community GH peptides + KLOW blend saved my hair. before and after pics.
Using finasteride and peptides, including GHK-Cu, improved hair thickness and regrowth. The user also used a KLOW blend and CJC/IPA for better sleep and recovery.
community Hormone test results - anybody else have similar with fin/dut
community 4 month progress (23M) on the Big 3. [NW7 when I started, I think]
A 23-year-old man shared his 4-month hair regrowth progress using 1mg oral finasteride daily, 5% minoxidil with finasteride topical twice a day, multivitamins, microneedling, head massages, and ketoconazole shampoo. He's unsure of his current Norwood scale classification and is asking for help to determine it, with suggestions ranging from NW4 to NW4.5.
community Is this regrowth? 2 months and 2 weeks comparison.
The conversation is about a user questioning if they have experienced hair regrowth after using topical minoxidil and oral finasteride for 2 months and 2 weeks, with mixed opinions on whether the perceived changes are due to lighting or actual regrowth. Most users suggest that noticeable regrowth typically takes 6-12 months, and the differences in photos may be due to lighting and hair styling.