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    GlossaryHomeostasis Model Assessment

    method to quantify insulin resistance using fasting glucose and insulin

    The Homeostasis Model Assessment (HOMA) is a method used to quantify insulin resistance and beta-cell function. It involves calculating an index based on fasting blood glucose and insulin levels, helping to assess how well the body maintains stable blood sugar levels. This is particularly useful in diagnosing and managing conditions like diabetes.

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      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  43 upvotes 6 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 3 years ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  91 upvotes 3 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community KX-826: Long-Term Safety Results are out!

      in Research/Science  158 upvotes 1 year ago
      KX-826 initially improves hair growth but declines after 24 weeks, with mild itching as a side effect. Combining it with minoxidil and finasteride may improve results, but long-term effectiveness is uncertain.

      community Update on my progress after 10,5 months

      in Progress Pictures  149 upvotes 1 year ago
      The user has been using a combination of oral finasteride, oral dutasteride, topical and oral minoxidil, microneedling, and keto shampoo for hair loss, experiencing significant shedding recently. Suggestions include simplifying the regimen by dropping finasteride and topical minoxidil, and possibly adding RU58841, while others advise maintaining the current approach for consistent results.

      community New Treatments, and a Huge Group Buy with Lots of Research

      in Research/Science  109 upvotes 2 years ago
      A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

      community Can anyone confidently say their erections are the same on fin ?

      in Chat  240 upvotes 1 year ago
      The conversation discusses the impact of finasteride on sexual function, with many users reporting reduced libido and weaker erections despite continuing the treatment to prevent hair loss. Some users suggest checking hormone levels or switching to different dosages or treatments like dutasteride, while others share mixed experiences regarding the severity of side effects.

      community Binding affinity of pyrilutamide!

      in Update  169 upvotes 3 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community blood DHT levels shot up after doubling dutasteride dosage

      in Finasteride/Dutasteride  20 upvotes 1 year ago
      A user increased their dutasteride dosage from 0.5mg to 1mg daily, resulting in a rise in DHT levels from 148 pg/mL to 281 pg/mL, and is considering switching back to finasteride due to continued hair loss. Replies suggest retesting and emphasize the importance of bloodwork before starting treatments.

      community What to do if fin is still not working after 2.5 years

      in Finasteride/Dutasteride  22 upvotes 10 months ago
      The user is experiencing increased hair loss despite using finasteride and oral minoxidil and is hesitant to switch to dutasteride due to side effects and family planning concerns. Alternatives suggested include dutasteride, microneedling, and addressing stress or nutrient deficiencies.

      community Bile Acid-Mediated DHT Dysregulation Hypothesis

      in Research/Science  13 upvotes 1 year ago
      Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.

      community Dutasteride is for Young Hair Loss Suffers

      in Finasteride/Dutasteride  104 upvotes 1 year ago
      Dutasteride is discussed as a treatment for young hair loss sufferers, with mixed experiences regarding side effects and effectiveness. Some users report positive results with Dutasteride, while others prefer Finasteride or Minoxidil due to fewer side effects.

      community Am I the least responder here?

      in Progress Pictures  15 upvotes 2 years ago
      A user struggling with hair loss has been using treatments including Minoxidil, a hair serum, vitamin capsules, and Dutasteride as prescribed by a dermatologist. They're experiencing side effects from Dutasteride and are unsure about its effectiveness, but another user suggests they might be seeing improvement and advises trying a lower dose.

      community Finasteride (0.5mg) & Topical Minoxidil Progress over 2.5 years

      in Progress Pictures  356 upvotes 2 years ago
      The conclusion of the conversation is that the user, AdamC11, has been using finasteride (0.5mg daily) and topical minoxidil for 2.5 years and has seen good progression and maintenance with no negative effects. They plan to continue with their current treatments as long as their hair holds, and will consider more potent treatments if they start losing ground.

      community i hate how much i’m stressing about hair loss

      in Chat  78 upvotes 3 years ago
      Someone who is starting to experience hair loss and is considering multiple treatments, such as minoxidil, finasteride, dutasteride, and a hair transplant, to manage it. Replies provide advice on how to approach these treatments safely and effectively.

      community Comprehensive Microneedling Guide

      in Microneedling  288 upvotes 3 years ago
      Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.

      community Trying to understand finasteride side effects and post finasteride syndrome

      in Finasteride/Dutasteride  68 upvotes 5 years ago
      The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

      community How to make topical melatonin?

      in Treatment  1 upvotes 2 years ago
      The conversation is about creating a topical melatonin treatment for hair loss. Specific treatments discussed include Minoxidil, Finasteride, and RU58841.

      community Cypro to reverse hairloss + Fin?

      in Treatment 9 months ago
      The conversation discusses using cyproterone temporarily to reverse hair loss, followed by finasteride to maintain regrowth. Concerns about cyproterone's side effects, such as lowering testosterone and potential health risks, are raised, with alternatives like spironolactone suggested for androgen-related issues.