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210-240 / 1000+ resultscommunity Going from ingesting topical minoxidil to oral tablets?
community Ketocanzole 2% has almost completely recovered my hair loss
Ketoconazole 2% shampoo effectively regrew hair by treating scalp dermatitis and inflammation. The user also used jojoba and oat oil, Aveeno moisturizer, and hyaluronic acid for scalp care.
community What’s your views on clascoterone 5% topical solution by cosmo
Clascoterone 5% topical solution shows promise for treating male-pattern hair loss by blocking DHT at the follicle without systemic absorption, potentially offering fewer side effects than oral treatments like finasteride. While results are promising, long-term safety and effectiveness need further study, and it may serve as a starting point for developing more effective treatments.
community EMA is re-examining Winlevi (clascoterone at lower concentration)
Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.
community Can I use this cream to increase minoxidil absorption?
The conversation is about using a cream to increase minoxidil absorption for hair loss treatment. The user is considering using tretinoin cream on the scalp but is unsure about its safety.
community Cassiopea Announces FDA Submission of New Drug Application for Clascoterone Cream 1%, the First New Mechanism of Action for Acne in Nearly 40 Years
The conversation is about a new acne treatment cream called Clascoterone Cream 1%, which is the first new mechanism of action for acne in nearly 40 years. One person joked about hoping their face will be as clean as their bald head after using the cream.
community Question about Topical finasteride
community I just order H&W's 1.25% Topical Finasteride - who's tried this?
A user ordered H&W's 1.25% Topical Finasteride and is curious about others' experiences and side effects. Another user asked about availability in the US.
community What Hinders the Absorption of Minoxidil?
Silicone and dimethicone in shampoos may hinder Minoxidil absorption, while Tretinoin and microneedling can enhance its efficacy. Users discuss applying Tretinoin before Minoxidil, waiting for it to dry first.
community Tretinoin can enhance the skin permeability of Minoxidil approximately 3-fold at 0.05%[24] and itself has some hair regrowth properties.
The conversation discusses enhancing Minoxidil absorption for hair loss treatment using Tretinoin and MSM (Methylsulfonylmethane). The user is seeking sources for Tretinoin and mentions MSM's potential to improve the absorption of topical agents.
community RU58841 vehicle penetration (Study for minoxidil)
The user mixes their own RU58841 solution and found that increasing the ethanol content improved absorption and reduced scalp itching. A study on minoxidil showed that penetration increased with higher ethanol concentrations, reaching maximum penetration at 90% ethanol.
community Can someone explain the drug interaction between dutastride and ketoconazole please?
The user is concerned about the interaction between dutasteride and ketoconazole, leading them to stop using ketoconazole shampoo, which has resulted in an oily and painful scalp. They are unsure whether ketoconazole increases or decreases the potency of dutasteride.
community Thinking of crushing bicalutamide/spiro or any other test suppressant in my topical fin min mix. What do yall think?
The conversation is about adding crushed bicalutamide or spironolactone to a topical mix with finasteride and minoxidil to suppress testosterone in hair follicles, similar to what RU58841 does. The user cannot obtain RU58841 in their country and is seeking advice on this alternative approach for hair loss treatment.
community I just started a topical cetirizine treatment.
The conversation is about using topical cetirizine for hair loss treatment. The user mixes Aller-TEC tablets with a hair tonic but faces issues with the solution's consistency.
community How come topical fin doesn't deliver superior results when it suppresses scalp DHT more effectively than oral?
Topical finasteride is believed to reduce scalp DHT more than oral forms, but its effectiveness is questioned due to inconsistent application and absorption. Oral finasteride is considered more effective because it consistently reduces systemic DHT, ensuring more reliable results.
community Can I use adapalene instead of tretinoin for minoxidil absorption?
Adapalene can be used instead of tretinoin for minoxidil absorption, but it is not as strong. Tretinoin is a more potent retinoid.
community Method for creating 0.01% duta topical solution, will this work?
The conversation discusses creating a 0.01% topical dutasteride solution mixed with minoxidil for hair loss treatment, with concerns about absorption and effectiveness. Some users suggest that dutasteride needs specific formulation for better absorption, while others recommend oral use for practicality.
community How much would a high dose dutasteride scalp dht inhibition be?
The conversation discusses the potential for high doses of dutasteride to completely inhibit scalp DHT and speculates whether this could cure baldness when combined with a topical antiandrogen. Specific dosages mentioned are 0.5 mg reducing scalp DHT by 55% and 2.5 mg by about 79%.
community Female AGA - Low Cortisol/Low DHEA
Female (37) experiencing hair loss for 5 years, tried max dose of spiro and oral + topical minox without success. Discovered low cortisol and low DHEA levels, seeking functional medicine practitioner for help.
community Hi, I got some regrowth recently and I attribute it to DICLOFENAC
The user started balding at 16/17 and tried various treatments including minoxidil, finasteride, and dutasteride with little success. They recently started applying diclofenac gel to their bald areas and noticed some hair regrowth, attributing this to diclofenac's ability to lower prolactin levels and its anti-inflammatory effects.
community Topical spironolactone — how many ml do you apply?
The conversation discusses the use of topical spironolactone for hair loss, with the original poster applying 8 ml daily but learning that 2 ml is recommended. It also touches on hair transplants and the role of DHT sensitivity in hair loss, emphasizing individual differences in treatment outcomes.
community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?
The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.
community Why is scalp DHT suppression lower than systemic?
Dutasteride reduces DHT more effectively in hair follicles than finasteride, but some individuals still experience hair loss despite treatment. Combining oral and topical finasteride may improve results, and some users experiment with topical dutasteride despite uncertainties about its absorption.
community actifolic tretinoin application to improve minoxidil absorption. How much of this to use? before or after monoxidil?
The conversation discusses using Actifolic tretinoin to enhance the absorption of Minoxidil for hair loss treatment. It questions the amount of tretinoin to use and whether to apply it before or after Minoxidil.
community Dermatologist prescribed Betamethasone dipropionate 0.05% lotion for hair loss.
A user noticed increased hair loss and was prescribed Betamethasone dipropionate 0.05% lotion by a dermatologist. Another user suggested changing doctors and asking for finasteride instead.
community cb-03-01 research chem (winlevi/clascoterone cream)
The user is considering using CB or clascoterone for hair loss, potentially as an alternative to RU. They're also contemplating asking a dermatologist for topical clascoterone cream to apply to their temple.
community Topical Finasteride that doesn’t go systematic is the cure
Topical finasteride that doesn't penetrate the skin could potentially treat hair loss without side effects. Current challenges include finding a formulation that remains on the scalp without increasing blood levels.
community How to use tretinoin for maximum minoxidil absorption
Using tretinoin to enhance minoxidil absorption for hair loss treatment. Apply tretinoin, wait 30 minutes, then apply minoxidil; use moisturizer to manage skin reactions.
community What happened to the 40mg dutasteride daily and Cyclosporine dude?
A user previously claimed to take 40mg of dutasteride daily and planned to try Cyclosporine, but their account and comments have since been deleted, raising concerns about their well-being. Other users discussed the risks and effectiveness of high doses of dutasteride, with some sharing their own experiences using dutasteride, finasteride, and minoxidil for hair loss treatment.