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      community Pp405 phase 2a clinical results

      in Research/Science  38 upvotes 9 months ago
      PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.

      community Added witch hazel to my daily routine

      in Treatment  1 upvotes 3 years ago
      The user added witch hazel to their routine with finasteride and topical minoxidil to reduce scalp itching and potentially help with hair loss. They find witch hazel affordable and effective for itch relief, though its impact on hair loss is still uncertain.

      community IGF-1 and Peptides? Miracle molecule waiting to be found

      in Research/Science  10 upvotes 7 months ago
      The conversation discusses potential hair loss treatments focusing on stimulating IGF-1 at the follicle level using growth-factor cocktails and engineered peptides, such as Acetyl Tetrapeptide-3, Copper Tripeptide-1, Oligopeptide-20, Thymosin-β4, and Palmitoyl Tetrapeptide-7. It suggests that device-assisted delivery methods like microneedling may enhance effectiveness.

      community Keratin microspheres - breakthrough

      in Research/Science  14 upvotes 2 years ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Topical minoxidil and Body hair

      in Minoxidil  6 upvotes 2 years ago
      Topical minoxidil can cause increased body hair due to systemic absorption, varying by individual skin sensitivity. The user seeks experiences and solutions to prevent this side effect.

      community No, Finasteride as a treatment for MPB was not an "accident"

      in Research/Science  106 upvotes 4 years ago
      Finasteride was intentionally developed to treat BPH and later approved for male pattern baldness (MPB) due to its 5AR inhibition effects. The delay in MPB approval was due to concerns about off-label use for female hirsutism and the prioritization of treating a more debilitating condition.

      community [M30] Constant swing between continuing or quitting Finasteride

      in General  204 upvotes 8 months ago
      A 30-year-old man is considering quitting Finasteride due to sexual side effects, including reduced libido and difficulty reaching orgasm, despite its effectiveness in treating hair loss. He is exploring other factors like relationship issues and potential low testosterone, and is considering getting blood work done.

      community Does an increase in testosterone increase hairloss?

      in Chat  7 upvotes 2 years ago
      Finasteride and minoxidil are effective for hair growth, but increasing testosterone, even naturally with ashwagandha, may increase DHT, potentially affecting hair loss if predisposed to male pattern baldness. Testosterone replacement therapy (TRT) can be beneficial for energy and muscle gain but may expedite hair loss if already prone to it.

      community Is this much of a hair shed a good sign after starting nuclear stack? Ok

      in Treatment  36 upvotes 1 year ago
      The conversation discusses hair shedding after starting a treatment regimen including topical dutasteride, RU58841, minoxidil, and keto shampoo. Shedding is considered normal, and users suggest adjustments like increasing dutasteride dosage or using oral medications for better results.

      community Comprehensive stack. Is it working?

      in Is this regrowth?  9 upvotes 1 year ago
      The user is using a comprehensive hair loss treatment including oral dutasteride, minoxidil (both oral and topical), topical finasteride, RU58841, ketoconazole shampoo, and a derma roller, while also using anabolic steroids. Opinions vary, with some users noting stability or slight improvement, while others suggest the treatment may not be effective due to anabolic use.

      community Update on Insane dutasteride shed

      in Progress Pictures  9 upvotes 2 years ago
      The conversation is about someone's experience with hair loss and their progress using dutasteride, a treatment for hair loss. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Oral Dutasteride before vs After !

      in Finasteride/Dutasteride  75 upvotes 1 year ago
      A 27-year-old male experienced hair thickening using a specialized pill containing Dutasteride and Minoxidil, despite taking it irregularly due to being away from home. He plans to resume a more regular dosing schedule for better results, as he noticed side effects like brain fog and decreased libido.

      community HMI-115 question about potential earliest access

      in Research/Science  10 upvotes 3 years ago
      Hair loss treatments discussed include Minoxidil, Finasteride, and RU58841. HMI-115, a monoclonal antibody drug, is in phase 1 and 2 trials for different conditions, but its availability on the gray market is unlikely due to high production costs.
      Question about finasteride

      community Question about finasteride

      in General  32 upvotes 1 year ago
      Finasteride may help thicken baby hairs on the crown, potentially reducing visible bald spots. Effectiveness varies for each individual.

      community Tom Cruise at the Mission Impossible premiere hair.(He's 61 y/o)

      in Chat  392 upvotes 2 years ago
      The conversation speculates on whether Tom Cruise uses hair loss treatments like Finasteride or Dutasteride, with some suggesting he naturally has good hair like Brad Pitt, while others joke about Scientology or genetics playing a role. Specific treatments mentioned include Finasteride, Dutasteride, and possibly high-quality hair products or procedures like PRP (Platelet-Rich Plasma).

      community GT20029 - Promising phase II results

      in Research/Science  16 upvotes 1 year ago
      GT20029 showed significant hair growth and safety in phase II trials, with no adverse sexual events. Users are hopeful but concerned about future costs and systemic effects.

      community The expected timeline for PP405 - Next update at AAD Annual Meeting in March 2026 ?

      in Treatment  30 upvotes 4 months ago
      A new hair loss treatment, PP405, showed promising Phase 2a results with 31% of patients experiencing over 20% hair density increase without systemic absorption, avoiding hormonal side effects. The treatment is expected to be expensive, with Phase 3 trials starting mid-2026, and there is skepticism about the data's strength.