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Pelage plans to conduct two Phase 3 trials for PP405, a new hair loss treatment, which may take about a year to complete. Users discuss various hair loss treatments, including pyrilutamide, minoxidil, finasteride, and clascoterone, with some expressing impatience over the lengthy trial process compared to faster drug approvals like the COVID vaccine.

The user experienced significant hair regrowth after 3.5 months using a topical 2-in-1 from Hims, ketoconazole, and weekly microneedling. The user is 37 years old.

The conversation discusses a topical finasteride therapy with hydrocortisone butyrate, estrone base, and breviline. A user suggests oral finasteride as a superior option.

Switching from ketoconazole to a ciclopirox and zinc pyrithione shampoo significantly reduced hair fall. The user is considering whether to continue using ketoconazole occasionally or combine both shampoos weekly.

A 28 year old using a hair loss prevention protocol to restore thinning hair, which includes finasteride, dutasteride, minoxidil, stemoxydine, alopecin, nizoral shampoo and microneedling; the user is now adding pyrilutamide solution to the regimen with the hope of improving their results. RU58841 was also ordered but not yet used.

A 20-year-old male uses oral finasteride daily, ketoconazole shampoo, rosemary and castor oil, and dermarolls for hair loss. Despite initial shedding and some baby hair growth, he worries these treatments may not be enough long-term.

Bryan Johnson uses topical dutasteride, minoxidil, and microneedling for hair loss. Users discuss treatment effectiveness and side effects, debating topical versus oral dutasteride efficacy.

HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

The conversation discusses severe hair shedding and thinning, with the original poster using finasteride, oral minoxidil, and other supplements without improvement. The discussion highlights the possibility of telogen effluvium and the importance of addressing potential underlying health issues, such as stress and gut health, rather than assuming diffuse unpatterned alopecia (DUPA).

The user shares their hair growth progress using topical and sublingual minoxidil, dutasteride, hormone replacement therapy, and a laser comb. They report thicker hair and reduced hairline shedding, seeking advice for further thickening.

User shares one-year hair transplant results with 3633 FUE grafts. Responses discuss improved appearance, hairline looking pluggy, and doctor's location in Ottawa, Canada.

The conversation discusses hair regrowth progress from November 2023 to April 2024 using 1mg finasteride, 5% minoxidil, and weekly dermarolling. The consensus is that there is some improvement and increased density, with expectations of further progress.

A user is using topical finasteride, keto shampoo, microneedling, and tretinoin for hair loss and is considering adding pyrilutamide. They notice some improvement at the temples and seek advice on whether to focus on cosmetic results despite daily shedding.

The user experienced hair regrowth using finasteride, minoxidil, dermarolling, and a castor oil and peppermint mix after initially having a significant hair loss. They reported no lasting side effects from finasteride and believe dermarolling contributed to their hairline growth.

A 16-year-old female experiencing severe hair loss and sebum buildup, likely due to telogen effluvium and PCOS, is currently using vitamin D3 supplements, Redenser serum, and T follihair supplements. Recommendations include addressing PCOS first and consulting a doctor.

Exosomes combined with fractional picosecond laser treatment were effective in treating androgenetic alopecia and promoting repigmentation in white hair patches. The role of exosomes in hair repigmentation, particularly in conditions like poliosis, is not well-studied.

User experienced slow gains with topical fin+min, switched to topical dut+min, and considered adding Eucapil. Another user suggested DUT may be less effective topically due to high molar mass and mentioned Fluridil as a weak anti-androgen that could help.

ABS-201 shows promise for male hair regrowth by blocking the prolactin receptor, with higher expected efficacy than current treatments. The discussion also covers dosing differences between macaques and humans for hmi115, highlighting a significant dosage disparity.

The user has been experiencing continuous hair loss despite using finasteride, minoxidil, and dermastamping. They are seeking advice on what to do next.

The user is asking if observed hair growth is new or old hairs dying off. They mention using finasteride, minoxidil, and microneedling.

The user has been using Minoxidil, vitamins, and a derma roller for 2.5 months with some regrowth observed. They are hesitant to add finasteride or dutasteride due to potential side effects, considering topical finasteride as a safer option.

A user is concerned about a growing thin spot on their boyfriend's head despite using Rogaine, Vitamin K, Vitamin E, Biotin, and Ubiquinol. Another user suggests starting finasteride, minoxidil, and dermarolling for better results.

The user has been using 1mg finasteride, 5% topical minoxidil daily, Nizoral shampoo, hair oils, and derma stamping at 1.5mm for hair loss. They plan to increase derma stamping frequency to 3-4 times a week for potentially better results.

The user changed their hair loss treatment in October/November, experienced increased shedding, and now sees no new hair growth, with a worsening condition and a possible bald spot. They also have severe seborrheic dermatitis, which may be affecting their scalp and hair loss.

Clascoterone phase 3 results show promising improvements in hair count, but concerns about high costs and lack of detailed data remain. Users compare it to existing treatments like Minoxidil and Finasteride, expressing skepticism about its accessibility and effectiveness.

The user experienced hair shedding after stopping minoxidil and resumed using minoxidil 5% twice daily, topical finasteride 0.1% twice a week, along with dermarolling, head pinching, deep massaging, and inversion techniques. They are seeking suggestions to maximize hair regrowth efforts and have observed some progress.

The user's experience with hair loss, their doctor explaining that they were likely hyper aware of thin spots due to anxiety and an underlying whorl in one area, and providing encouragement for those feeling discouraged. Treatments mentioned include minoxidil and spironolactone.

A user is seeking non-transplant hair treatments in Seoul, such as scalp detox, PRP, and exosomes, before considering a future transplant with Dr. Zarev. They want to explore options that improve hair health without undergoing a transplant immediately.

Adipose-derived stem cells with ATP improved hair regrowth in male and female mice with androgenetic alopecia. The most effective treatments were low dose stem cells with ATP for males and medium dose stem cells with non-liposomal ATP for females.

The conversation is about starting microneedling for hair growth, with questions on needle sizes, session frequency, and reliable purchasing options. The user seeks clarity on FDA regulations and prefers to avoid certain online retailers.