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GlossaryHyperuricemia

excess uric acid in blood, potentially causing gout

Hyperuricemia is a condition characterized by an excess of uric acid in the blood. Uric acid is a waste product formed from the breakdown of purines, which are substances found in certain foods and drinks. When the body produces too much uric acid or fails to excrete enough of it, the excess can lead to the formation of sharp, needle-like urate crystals in a joint or surrounding tissue, causing pain and inflammation, commonly known as gout. This condition can also be associated with other health issues such as kidney stones and cardiovascular diseases.

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community 5ARI (dutasteride) Associated with Adverse Metabolic Effects

25 upvotes 8 years ago

Dutasteride is associated with increased blood glucose, HbA1c, LDL cholesterol, and liver enzyme activity, potentially leading to diabetes, NAFLD, and liver metabolism changes. The conversation highlights concerns about these adverse effects and calls for more studies, including on finasteride.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 18 upvotes 3 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.

community blood DHT levels shot up after doubling dutasteride dosage

in Finasteride/Dutasteride 20 upvotes 1 year ago

A user increased their dutasteride dosage from 0.5mg to 1mg daily, resulting in a rise in DHT levels from 148 pg/mL to 281 pg/mL, and is considering switching back to finasteride due to continued hair loss. Replies suggest retesting and emphasize the importance of bloodwork before starting treatments.

community DHEA, the culprit behind DUPA ? Read this!

in Research/Science 19 upvotes 2 years ago

High DHEA levels may contribute to hair loss by increasing DHT in hair follicles, potentially explaining why finasteride is ineffective for some. Treatments like high-dose dutasteride and RU58841 are suggested, but the underlying cause, such as adrenal issues, should be investigated.

community Treating my DUPA via controlling inflammation

in Treatment 5 upvotes 2 years ago

The user has DUPA and suspects autoimmune activity as a cause. They have tried various treatments including finasteride, minoxidil, dutasteride, pyrilutamide, estrogel, hydrocortisone, and clobetasol, and are now seeking a long-term immunosuppressant.

community Unexpected Serum DHT Elevation after Generic Dutasteride Use.

in Finasteride/Dutasteride 38 upvotes 10 months ago

Switching from finasteride to a generic dutasteride led to unexpectedly high DHT levels, prompting a switch to a reputed brand and consideration of softgel capsules for better absorption. The user plans to retest DHT levels and may return to finasteride if issues persist.

community PG causing irritation when applying RU

in Research/Science 2 years ago

The user is experiencing irritation from using PG with RU58841 and is seeking alternative solutions like K&B in the UK. They report redness, itchiness, and flaky skin from the current treatment.

community Finasteride 1 mg - Increase in pee urge

in General 37 upvotes 1 year ago

The user has been taking finasteride for nearly two months and has noticed an increased urge to urinate with slight discomfort. They are questioning if this side effect is temporary.

community Has anyone figured out what causes the cardiovascular issues with RU?

in Chat 4 upvotes 1 year ago

RU58841 and Minoxidil can cause heart-related side effects like chest pain and heart racing. Pyrilutamide is suggested as a safer alternative, though it's new and costly.

community Helicobacter's concocted serum v1

6 upvotes 7 years ago

A custom-made serum based on double-blind studies for AGA, which includes natural ingredients such as rosemary oil, procyanidin B-2, saw palmetto extract, curcuma aeruginosa, pumpkin seed oil and castor oil. The user has updated their recipe to include apple poly procyanidin B-2 4% concentration and other ingredients before topping it off with Pura d'or serum.

community Finasteride - discomfort pelvir/urethra

in Finasteride 79 upvotes 11 months ago

Finasteride can cause pelvic or urethral discomfort for some users. Reducing the dose to 0.25 mg on Mondays, Wednesdays, and Fridays is being considered as a potential solution.

community Dutasteride and elevated (LDL) cholesterol

in Finasteride/Dutasteride 1 upvotes 1 year ago

The user switched from finasteride to dutasteride for hair loss and noticed elevated cholesterol levels, questioning if dutasteride caused this change. They also take Vitamin D, biotin, magnesium, ginkgo biloba, omega-3, and NAC, and are concerned about the impact of these supplements and their health on cholesterol levels.

community PSA: My GP told me you should get yearly kidney and liver tests if you are on Dutasteride

in Update 15 upvotes 1 year ago

Dutasteride users should get yearly kidney and liver tests, especially young people. General health checkups are not common in the UK, but such tests are recommended as a precaution.

community Hives/Rash from Kx 826 Pyrilutamide???

in Chat 1 upvotes 1 year ago

OP developed hives after using Kx 826 (Pyrilutamide) 1% twice daily for 3 weeks. The hives appeared on the arms, chest, and groin area.

community pyrilutamide GB update please? Anything no matter how big or small

in Update 35 upvotes 3 years ago

The effects of Finasteride on hair loss and its side-effects, such as aching balls. The user has been taking it for two years with no changes to the symptom.

community pyrilutamide 0.5% vs. ru58841 5%? is RU stronger because of the higher concentration?

in Technology 3 upvotes 1 year ago

The conversation is about comparing the effectiveness of 5% RU58841 and 0.5% pyrilutamide for hair loss treatment. The user is asking if the higher concentration of RU58841 makes it stronger than the lower dose of pyrilutamide.

community Anyone experienced weight gain on dutasteride?

in Finasteride/Dutasteride 5 upvotes 3 years ago

Dutasteride can lead to increased cholesterol and liver fat. The user is reconsidering its use due to high cholesterol and lipid levels despite a healthy lifestyle.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 127 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community ghk-cu is potent 5-ar inhibitor?

in Product 9 upvotes 2 years ago

GHK-Cu is a potent inhibitor of the type 1 5-alpha reductase enzyme in hair follicles, which may reduce hair loss without the side effects associated with type 2 5-alpha reductase inhibitors. The user previously experienced side effects with 5-alpha reductase inhibitors and is considering GHK-Cu as an alternative.

community CRAZY HIGH? 1% Fin 0.3% GHK-CU topical perscription

in Treatment 2 upvotes 2 months ago

The conversation discusses concerns about using a high concentration of 1% topical finasteride for hairline balding, with some users suggesting starting with a lower dose. It also mentions the use of GHK-CU peptide and the importance of considering the formulation to avoid excessive absorption.

community Blood Results (UPDATED) TOTAL T 1279 ng/dL- 2 Yrs on Fin / 1.5 Yrs on Dut

in Finasteride/Dutasteride 9 upvotes 10 months ago

The user has been using a hair loss treatment regimen including RU58841, minoxidil, and dutasteride, but still experiences hairline recession and fatigue despite high testosterone levels. They are considering adjusting their dutasteride dosage due to concerns about libido and energy levels.

community DHT is higher on DUT than on FIN. Why?

in Finasteride/Dutasteride 13 upvotes 2 years ago

The conversation discusses the fluctuation of testosterone levels in men under 40 and the difference between serum DHT and scalp DHT. It also mentions that DHT levels are higher on Dutasteride than on Finasteride, which is unusual.

community A warning to those thinking about using Dutasteride

in Finasteride/Dutasteride 99 upvotes 6 years ago

The potential risks of long-term use of Dutasteride and how it may be linked to elevated liver enzymes, cholesterol levels, and decreased testosterone. Alternative treatments such as Finasteride and RU58841 were also discussed.

community 22M High Estrogen after blood test

in Finasteride/Dutasteride 1 upvotes 3 months ago

A 22-year-old male with high estrogen levels is considering finasteride for hair loss but is concerned about potential side effects due to his hormone levels and family history of diabetes. Users suggest consulting a doctor, possibly an endocrinologist, and considering lifestyle changes like diet and exercise to address visceral fat and insulin resistance before starting treatment.

community pyrilutamide phase 2 results right here, thanks to user Glaringbooch

in Chat 41 upvotes 4 years ago

Pyrilutamide, a new drug being tested to combat hair loss that has been found to perform comparably or better than finasteride and dutasteride in the initial 6 months of treatment with minimal reported side effects.

community DHT LEVEL IS 700pg/ml AFTER 8 MONTHS OF DUTASTERIDE

in Finasteride/Dutasteride 22 upvotes 1 year ago

The user had high DHT levels after 8 months on dutasteride, questioning the drug's authenticity. They got dutasteride from a legitimate source and will update on progress.

community Highest DHT level you’ve seen?

in Update 6 upvotes 3 weeks ago

The conversation discusses starting finasteride 1mg daily for hair loss and mentions a high baseline DHT level. Users comment on the unusually high DHT level and its potential causes.

community questions for the pyrilutamide users here

in Treatment 7 upvotes 3 years ago

The conversation discusses the storage and use of pyrilutamide for hair loss, where one user advises against keeping it in the freezer as it may crystallize the active compounds.

community Got some bloodwork done, horrifying results.

10 upvotes 9 years ago

The user is concerned about high DHT levels despite using finasteride and dutasteride for hair loss, suggesting these treatments may not be effective. They plan to consult an endocrinologist and consider other antiandrogens, acknowledging potential side effects.

community Solo use of Pyrilutamide: UPDATE

in Update 45 upvotes 3 years ago

A user who has been using Pyrilutamide for 19 days, experiencing some hair thickening in the right temple and crown area but also having ball ache after microneedling; other users offer advice, caution and skepticism as to whether results can be seen in such a short time.