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      community Proof that finasteride messes with neurosteroids

      in Research/Science  230 upvotes 2 years ago
      Finasteride can impact neurosteroids, potentially causing depression and other side effects in some users. Despite these concerns, many continue using it for hair loss, with some switching to topical applications to mitigate side effects.

      community RU58841, 8% HPLC-MS done by jano, they legit

      in Research/Science  6 upvotes 4 years ago
      The conversation is about testing the effectiveness of RU58841 for hair loss, with the user planning to increase their dose to 30 mg per day along with 20 mg of Minoxidil. The test results showed approximately 70 mg/ml, which the user considers a good result.

      community Minoxidil: How It Changes the Scalp Hormone Environment

      in Research/Science  80 upvotes 5 months ago
      Minoxidil increases blood supply to the scalp, strengthening dormant follicles and extending the growth phase, but may increase scalp activity that can be countered with DHT blockers. Women experiencing side effects from finasteride or dutasteride for hair loss might consider alternatives like estrogen, especially if on birth control.

      community Fin is working; I’m just now noticing

      in Finasteride/Dutasteride  109 upvotes 2 years ago
      The user reports significant hair density improvement after 8.5 months of using finasteride, with no side effects except for initially watery semen. They also mention increased sex drive, which they attribute to finasteride, and regret not starting the treatment earlier due to fear of side effects.

      community Does caffeine inhibit 5-α-reductase?

      in Treatment  4 upvotes 6 years ago
      Caffeine may promote hair growth and potentially inhibit 5-α-reductase activity in hair follicles, but its effectiveness and systemic impact remain unclear. Users discuss using topical caffeine solutions, with some experiencing no side effects compared to finasteride.

      community Peppermint Oil vs Minoxidil

      in Minoxidil  6 upvotes 7 years ago
      The user experienced positive results for hair loss using minoxidil but stopped due to side effects like heart palpitations and increased body hair. They are considering peppermint oil as an alternative and are curious about its effectiveness and potential side effects.

      community Fluridil/topilutamide experince

      in Treatment  4 upvotes 2 years ago
      A user is trying fluridil/topilutamide for hair loss and experiencing side effects like pain in the testicles and genital discomfort. They previously had adverse effects with finasteride, dutasteride, and RU58841, and are considering other treatments like topical dutasteride and spironolactone for maintenance before a hair transplant.

      community Topical - Lantoprost .01%, MIN 10% DUT .05%, Hydrocortisone 1% Progrestron .025%

      in Treatment  6 upvotes 11 months ago
      A user was prescribed a topical treatment for hair loss including Latanoprost, Minoxidil, Dutasteride, Hydrocortisone, and Progesterone, after using an oral Minoxidil and Finasteride combo without significant results. Concerns were raised about the long-term use of hydrocortisone, with suggestions to consult a doctor regularly.

      community My dermatologist uses oral minox and dutasteride

      in Minoxidil  65 upvotes 3 years ago
      Treatments for hair loss and the potential side effects. The user discussed their doctor's advice to take 1.25 mg oral minoxidil and .5 mg dutasteride daily, with a warning that those with heart conditions should not take oral minoxidil. Other users shared their experiences, including taking finasteride and noting the possible overkill of the dosage prescribed by Jirons1's dermatologist.

      community PP405 2a study was a safety study. Some rational explaining.

      in Research/Science  23 upvotes 11 months ago
      The conversation discusses the safety study of PP405, emphasizing that early trials focus on safety rather than efficacy, and that any efficacy data from such a short study should be viewed skeptically. It also highlights that the information released is primarily for securing funding, and that meaningful efficacy results are expected in later phases.

      community We need actual hair loss studies on Epristeride

      in Research/Science  6 upvotes 1 year ago
      Epristeride is a selective 5 alpha reductase type 2 inhibitor that may reduce scalp DHT similarly to finasteride, with potentially fewer side effects. It is suggested that combining epristeride with finasteride or dutasteride could enhance hair loss treatment effectiveness.

      community Will you guys be trying the time-release oral minoxidil when it comes out?

      in Chat  18 upvotes 2 months ago
      People are discussing the potential benefits and drawbacks of a new time-release oral minoxidil (VDPHL01) for hair loss, with considerations about its cost, efficacy, and side effects compared to current treatments like 2.5mg doses and topical applications. Some users express interest in trying it if it proves effective and affordable, while others are cautious due to potential side effects or are satisfied with their current regimen.

      community ashwagandha while taking finasteride

      in Finasteride/Dutasteride  4 upvotes 8 months ago
      The user is considering taking ashwagandha while on finasteride to manage side effects, noting it reduces stress but may cause hair thinning. They are unsure if the thinning is due to ashwagandha or normal shedding from finasteride.

      community Minoxidil actually reduces wrinkles

      in Research/Science  209 upvotes 1 year ago
      Minoxidil may improve or worsen skin quality, with topical forms causing dryness and wrinkles, possibly due to alcohol content, while oral forms have fewer side effects. Some users consider using tretinoin to mitigate negative effects.

      community Is pyrilutamide safe to use or still unknown?

      in Research/Science  12 upvotes 3 years ago
      The conversation is about the safety and effects of using pyrilutamide for hair loss. One person reported severe negative effects, another experienced minor side effects without much benefit for hair, and a third found the anecdote helpful in making a decision.

      community So I have good results but theres a catch

      in Treatment  4 upvotes 4 years ago
      The user experienced good hair growth results using a combination of finasteride, minoxidil, and a topical formulation, but faced temporary numbness as a side effect. They manage this by microdosing oral finasteride and minoxidil and using the topical formulation sparingly.

      community Crazy idea: creatine + topical finasteride

      in Chat  22 upvotes 4 years ago
      Using topical finasteride with creatine might help reduce hair loss by targeting local DHT while maintaining normal systemic levels, but results are uncertain without testing. Users report mixed experiences with topical treatments like finasteride, dutasteride, RU58841, and minoxidil, with some seeing regrowth and others experiencing side effects.

      community Taking ashwagandha with finasteride

      in Chat  6 upvotes 1 year ago
      Ashwagandha is used to reduce stress and improve sleep, while finasteride is taken for hair loss. Users report positive effects from ashwagandha and mixed results from finasteride, with some experiencing a slight dip in libido.

      community Blood Results before and after Topical Finasteride mix with Minoxidil

      in Finasteride  10 upvotes 6 years ago
      A user reported that after using a topical mix of finasteride and minoxidil, their DHT levels decreased, testosterone and estradiol levels lowered unexpectedly, and they are considering vitamin D3 supplements due to deficiency. They apply the mix 3-4 times a week and use minoxidil on other days. Another user commented that finasteride typically increases testosterone, not decreases it.