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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Dht test results after 1year oral dut

      in Treatment  12 upvotes 2 years ago
      The user is experiencing increased hair shedding after one year of using oral dutasteride. They are seeking opinions on their DHT test results, which show levels below baseline.

      community Are these all vellus hairs that will go terminal?

      in Is this regrowth?  5 upvotes 8 months ago
      The user is using oral minoxidil, ghk-cu, and HGH for hair regrowth, noticing small vellus hairs on the crown. They avoid traditional DHT blockers like finasteride due to side effects, despite skepticism from others about the effectiveness of ghk-cu.

      community I hate hairloss to my core, Fuck this shit

      in Update  185 upvotes 4 months ago
      The user is frustrated with hair loss, having switched from topical minoxidil and finasteride to dutasteride and oral minoxidil without seeing improvements. They are considering a hair transplant and are advised to continue the current treatment and explore therapy or lifestyle changes.

      community TE turned into Scarring hairloss

      in Update  12 upvotes 2 years ago
      The user experienced hair loss due to a crash diet and later developed scarring hair loss. They are now on finasteride, oral minoxidil, LDN, Zyrtec, and Oztela to reduce scalp inflammation and promote hair regrowth.

      community I cry every day, everything is very depressing

      in Finasteride/Dutasteride  52 upvotes 1 year ago
      A user is experiencing hair loss despite using dutasteride and oral minoxidil, feeling hopeless and considering a hair system. They are advised to try ketoconazole, seek a second opinion from a dermatologist, and consider treatments like finasteride, RU58841, and hair transplants.

      community Is it something to be hopeful for?

      in Chat  2 upvotes 10 months ago
      The user is using finasteride, dutasteride, and topical minoxidil with tretinoin for hair loss but is concerned about the lack of growth in small hairs. Others suggest patience, as results can take up to two years, and emphasize the importance of exercise and diet.

      community second shed on dutasteride, but a woman

      in Finasteride/Dutasteride  2 upvotes 1 year ago
      A woman experiencing hormonal hair loss is on dutasteride and bicalutamide, which initially improved her hair, but she is now experiencing a second shedding phase with significant short hair loss. Despite normal hormone levels and no deficiencies, she is unsure if this shedding is normal and seeks advice.

      community Can topicals cause a never ending shed?

      in Treatment  2 upvotes 2 years ago
      The user reintroduced RU58841 and noticed increased shedding and visible thinning. They have also been using dutasteride and oral minoxidil for 2 years.

      community Tiny tiny hairs outlining juvenile hairline

      in Is this regrowth?  17 upvotes 1 year ago
      The conversation is about hair regrowth using high-dose dutasteride, oral minoxidil, and microneedling. Users discuss seeing tiny hairs and hope they will become terminal, with advice to use derma rolling weekly for better results.

      community Thoughts on my dermatologist only giving me methionine for AGA?

      in Treatment  4 upvotes 4 years ago
      A dermatologist prescribed methionine with vitamins for hair loss, but the user is doubtful and plans to seek finasteride in France. The user is unsure why finasteride or minoxidil wasn't prescribed, suspecting concerns about side effects or strength.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  57 upvotes 2 years ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community Stemson Therapeutics and hair cloning pipeline

       8 upvotes 6 years ago
      The conversation discusses the progress and potential of hair cloning by Stemson Therapeutics, questioning if it will be realized in the next 5-10 years or if it's just false hope. Specific treatments mentioned include Minoxidil, finasteride, and RU58841.

      community Here to share my happiness bros! DHT blockers are magic

      in Progress Pictures  115 upvotes 10 months ago
      The user experienced significant hair regrowth using finasteride and dutasteride, with noticeable results after switching to dutasteride. Minoxidil was deemed unnecessary due to the restoration of the hairline and lack of hair follicles in bald spots.

      community Anti androgen shed all over scalp

      in Treatment  3 upvotes 2 years ago
      The user is experiencing intense hair shedding all over the scalp after applying pyrilutamide to the hairline and taking oral castor oil. They are also using topical finasteride and latanoprost, but are unsure which treatment is causing the shedding.

      community Ferritin, iron and testosterone

      in Chat  4 upvotes 2 months ago
      Dutasteride may affect testosterone levels, leading to high ferritin and iron levels, which can cause hair loss. High ferritin might be linked to past heavy drinking or hemochromatosis.