community Is PP405 the New Cure for Hair Loss?! (Shocking Results!)
PP405 is humorously suggested as a new hair loss cure with "shocking results." The conversation includes references to Minoxidil, finasteride, and RU58841.
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990-1000 / 1000+ resultscommunity Homemade topical finasteride shelf life?
User makes topical finasteride with stemoxydine and proscar pills, stores at room temperature. Asks if solution goes bad in 3 months.
community Applying minoxidil right after microneedling at 0.5mm a bad idea?
Applying minoxidil immediately after microneedling at 0.5mm can cause stinging and potential systemic absorption, so some users prefer to wait 12-24 hours. Others report no issues with immediate application, but caution is advised to avoid irritation and side effects.
community Microneedling for maximum results?
Microneedling is discussed as a favorable hair loss treatment, with no consensus on whether to glide or remove the device between areas. Scalp irritation varies by individual, and some users report no need for gel during the process.
community Mixing Peppermint and Rosemary Oil into my minoxidil bottle give more hair
Mixing peppermint and rosemary oil with minoxidil improves hair growth. Users report positive results with this combination, using both liquid and foam forms of minoxidil.
community US FDA will now default to only one clinical trial for drug applications, will this accelerate the release of PP405 and other drugs in clinical trials?
The FDA will now require only one clinical trial for drug approval, potentially speeding up the release of hair loss treatments like PP405. Pelage is expected to present full results of PP405 Phase 2a trials and move to Phase III in mid-2026.
community How to deal with tretinoin burning effect?
Using tretinoin with minoxidil can cause burning and flaky skin due to alcohol in minoxidil and tretinoin's effects. Solutions include using minoxidil foam, starting with low tretinoin doses, moisturizing, and gradually increasing usage.
community Seeking Solutions for Itchy Scalp from Minoxidil and Tretinoin Use with Nizoral and Aloe
Minoxidil and tretinoin can cause scalp dryness and itchiness. Using Nizoral, aloe, a lighter minoxidil formula, or a water-based moisturizer like one with hyaluronic acid may help alleviate these issues.
community Any chemists want to manufacture PP405 / JXL069? (Steps inside)
The conversation discusses the synthesis and potential use of JXL069 and PP405 for hair loss treatment, with skepticism about their effectiveness and concerns about safety. Users mention that JXL069 has shown no results in hair growth, and there is confusion about its identity and effectiveness compared to PP405.
community Can using styling products like wax/clay and powders effect absorption of topical treatments?
A user is using Fluridil for hair loss and is concerned that styling clay and powder might affect the absorption of the treatment. They apply clay in the morning and Fluridil in the evening and are considering switching to a styling powder.