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After 3 months of using oral finasteride with oral minoxidil, shedding has started, and facial and body hair is growing back thinner. The user is questioning if a dosage increase is needed.

A 21-year-old male has been using dutasteride, minoxidil, ketoconazole shampoo, and microneedling for hair loss, with plans to increase minoxidil dosage. He is experiencing no side effects and is planning a trichoscopy to assess hair regrowth.

PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and increase hair growth by 20% in eight weeks, unlike minoxidil or finasteride. However, skepticism remains about its effectiveness and availability, with concerns about funding and the timeline for broader access.

The user experienced significant hair regrowth after 5 months using Minoxidil and Finasteride, specifically Hims chewables. They noted an increase in depression as a side effect.

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

A 24-year-old male experienced significant hair regrowth after 5 months of using Finasteride, with no other treatments like Minoxidil or microneedling. He also reported an increase in libido and no other side effects.

The conversation discusses using RU58841 at a 2% concentration as an alternative due to side effects from finasteride. The user plans to start with a lower concentration and increase if necessary.

People are excited about a new hair loss treatment, PP405, and some suggest using Twitter to increase its visibility. Current treatments mentioned include finasteride, minoxidil, and dutasteride, but skepticism remains about the effectiveness of new treatments.

A user shared their one-year progress using oral minoxidil and finasteride for hair loss, noting an increase in minoxidil dosage and the addition of microneedling. They feel progress is slow and are considering a hair transplant for full restoration.

PP405 is a potential new hair loss treatment that might replace finasteride and minoxidil, but it is still in clinical trials and may not be available until 2028-2031. There is skepticism about its effectiveness, with only a 20% increase in hair density observed in some participants.