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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community got my very first hair system :)

      in Hair Systems  378 upvotes 4 years ago
      User got a hair system after hair transplant and finasteride didn't meet their needs. Hair system cost $200, initial install $150, and user is satisfied with the results.
      There is hope guys, M28 75 days of Fin&Min

      community There is hope guys, M28 75 days of Fin&Min

      in Journals / Progress Pictures  91 upvotes 4 months ago
      A user shared progress pictures showing improved hair fullness after 75 days using 2.5mg oral minoxidil daily, 1mg oral finasteride every other day, a 1.5mm dermastamp weekly, and daily scalp massages. They report seeing early positive results.

      community 8months fin 4.5 months min progress

      in Progress Pictures  34 upvotes 1 year ago
      The user has been using 5mg oral Minoxidil daily and started with 1mg Finasteride daily, but reduced the dose due to side effects and is considering trying RU58841. They are concerned about thinning hair despite some temple recovery and are seeking advice on maximizing progress.
      M27 Fin/Min (topical) was fun while it lasted

      community M27 Fin/Min (topical) was fun while it lasted

      in Finasteride  126 upvotes 1 year ago
      The user experienced significant hair regrowth using topical Minoxidil and Finasteride but had to stop due to high liver enzyme levels. They plan to pause treatment for a month to see if their liver values return to normal.

      community Min month 1 vs month 3. Starting fin soon

      in Chat  4 upvotes 2 weeks ago
      The conversation is about a user who experienced hair growth after three months of using Minoxidil and plans to start Finasteride soon. The user is considering a hair transplant next year and is curious about the potential for further growth.

      community Starting Fin soon. Wish me luck

      in Finasteride/Dutasteride  4 upvotes 1 year ago
      A 19-year-old with NW2-2.5 hair loss is starting finasteride soon, considering low dosages of 0.25mg daily or 0.5mg 3-5 times a week. They are also using derma stamping, ketoconazole shampoo, ACV washes, and various oils to maintain hair quality and reduce scalp itch.

      community Min / Fin - M21 - 1.5 Year Update - Multiple Sheds

      in Update  15 upvotes 10 months ago
      The user experienced significant hair regrowth using 5% topical minoxidil and 1mg finasteride daily, despite multiple shedding phases, and emphasizes the importance of starting treatment early and maintaining consistency. They advise against obsessing over online forums during shedding periods and recommend checking for scalp conditions like seborrheic dermatitis and ensuring proper nutrition.

      community [M19] Before and After Treatment

      in Progress Pictures 3 years ago
      A user's progress pictures showing the results of taking Fin (0.5 mg per day), Min (5 mg per day) and microneedling with Dr. Pen Ultima M8; another user asked when the regrowth was noticed, and commented on the hair appearing darker.

      community Is there a spray that has fin/min/ru combined?

      in Research/Science  2 upvotes 1 year ago
      The user is seeking a topical spray combining finasteride, minoxidil, and RU58841 or dutasteride due to side effects from oral treatments. They believe an all-in-one topical solution would be easier for long-term use.

      community 3 months update on meds post HT

      in Progress Pictures  110 upvotes 1 year ago
      The user started using 1mg finasteride and Regaine foam post-hair transplant, noticing significant hair growth at three months. They experienced testicular cramps as a side effect but no other issues, and are considering microneedling for further improvement.

      community 3 months fin/min progress (age 31)

      in Progress Pictures  173 upvotes 1 year ago
      A user shared their 3-month progress using 1mg oral finasteride daily and 5% topical minoxidil twice daily, along with Pura D’Or anti-thinning shampoo and a scalp massager. They noticed initial worsening but later saw hair follicle recovery.

      community 5 months on dut/fin/min progress

      in Progress Pictures  175 upvotes 6 months ago
      The user experienced significant hair regrowth after 5 months using finasteride, dutasteride, and oral minoxidil, despite initial side effects like erectile dysfunction, which resolved after switching from finasteride to dutasteride. The user reports full recovery of hair density and improved skin condition, though the right temple remains slightly recessed.

      community HT scheduled. Am I over reacting?

      in Transplants  13 upvotes 10 months ago
      The user has scheduled a hair transplant after stabilizing hair loss with finasteride and minoxidil, considering additional dermarolling. They are advised to use 2500-3000 grafts conservatively for temple filling without lowering the hairline too much.

      community [24M] 4 month update oral min/fin

      in Progress Pictures  87 upvotes 1 year ago
      The user reported good progress in hair regrowth, especially on the crown, after using oral minoxidil and finasteride for four months and recently switched to dutasteride. The community responded positively, noting realistic progress and offering tips for consistent photo documentation.

      community Fluridil does work if used as add-on treatment.

      in Treatment  6 upvotes 2 years ago
      The user has been using Dutasteride for five years and noticed slow thinning on the frontal hairline. They tried Fluridil as an additional treatment, which resulted in noticeable hairline thickening after two months.

      community .3% Fin (3mo) & .6% Minox (10mo) Topical results.

      in Is this regrowth?  12 upvotes 1 year ago
      The user is experiencing hair regrowth using topical 0.3% finasteride and 6% minoxidil, with no side effects noted. They are considering switching to oral treatments if progress stalls, but are currently satisfied with the results.