Pyrilutimide and CB-03-01, two treatments for hair loss, have similar clinical trial results despite different binding affinities to androgen receptors. Factors other than binding affinity, like the time a drug stays bound to the receptor, may influence their effectiveness.
The conversation humorously discusses hair loss treatments, mentioning Minoxidil, finasteride, and RU58841. It jokingly suggests the creation of a new chemical called RU99999.
The user experienced sexual side effects from finasteride and switched to using only topical minoxidil without side effects. They are seeking alternatives to finasteride, such as topical finasteride, to maintain hair without adverse effects.
Crushing spironolactone pills and combining them with minoxidil for topical application may be effective for hair loss, with the addition of finasteride suggested. Adding rosemary and peppermint oils can help mask the unpleasant smell.
The user is considering using Tacrolimus Solution and topical Dutasteride to avoid shedding caused by Minoxidil, which they fear may lead to facial side effects. They are also concerned about scalp sensitivity and are exploring different treatment bases to manage seborrheic dermatitis.
The user is seeking Malassezia-safe treatments for hair loss and currently uses a baby shampoo, a scalp tonic with antifungal ingredients, and aloe gel. They consider using Kirkland Minoxidil 5% drops and possibly consulting a doctor about Finasteride.
The conversation discusses the effectiveness of peppermint oil and dermarolling for hair regrowth, with one person suggesting that only dermarolling is effective and comparing peppermint oil's effectiveness to that of an egg.
The conversation is about a user expressing concerns over the safety of a new drug called Pyrilutamide (also known as KX-826) for hair loss. The user will only trust the drug if it's permitted by EU regulations and sold by a reputable company.
The conversation is about finding shampoos with Piroctone Olamine in the US for itch relief, as the user has not found relief with Keto shampoo, oral Dutasteride, and oral Minoxidil. Users suggest alternatives like Neutrogena T/Gel and online options, but note availability and price issues.
The conversation is about the effectiveness of topical azelaic acid in blocking DHT for hair loss treatment. Specific treatments discussed include Minoxidil, finasteride, and RU58841.
A user stopped using finasteride and switched to a mix of essential oils in jojoba oil to treat hair loss, which reduced itching and hair shedding significantly. They shared their experience, noting that dermatologists were not helpful.
The conversation discusses making topical finasteride at home, questioning the necessity of removing the pill's coating before use. Users suggest that the coating isn't harmful, and finasteride dissolves in ethanol, with some recommending filtering out the coating and fillers.
A user suggests making a potent sulforaphane topical to degrade DHT and promote hair growth. Another user notes that sulforaphane's low molecular weight might also lower systemic DHT.
The conversation discusses Pyrilutamide for hair loss, with skepticism about its legitimacy and mentions of an upcoming press release from Kintor. It also references ongoing trials and includes links for further information.
The user shared their experience with CB-03-01 (Breezula/Clascoterone) for hair loss, noting reduced shedding and improved hair appearance but experiencing significant sleep disturbances and low energy due to HPA axis suppression. They decided to stop using it due to these side effects and are waiting for GT20029 as an alternative.
A user's scalp issue that may be causing their hair loss and potential treatments, such as salicylic acid, finasteride, minoxidil, ketoconazole shampoo, and visiting a dermatologist.
A user is seeking a hair-loss shampoo without salicylic acid due to an allergy. Recommendations include using Finasteride, Minoxidil, and Nizoral Anti-Dandruff Shampoo (ketoconazole), while avoiding Nizoral Scalp Psoriasis Shampoo & Conditioner.
The user switched to oral Dutasteride, added RU58841, and used Ketoconazole-enriched Minoxidil but still experiences scalp itch and hair loss after 4 months. They are advised to give Dutasteride more time, consider seeing a dermatologist, and explore other topical solutions.
A 23-year-old male switched to a topical solution containing Fin 0.1% and Min 5% from a previous solution with Fin 1% and Min 5%, noticing increased hair shedding. He is concerned about losing around 50 hairs while using ketoconazole shampoo.
People discussed solutions for scalp itching related to hair loss, with treatments including finasteride, dutasteride, ketoconazole shampoo, and Alpecin Hybrid shampoo. Some users found relief by adjusting dosages of finasteride or switching to dutasteride, while others recommended specific shampoos or prescription options like olux foam.
The conversation discusses whether Pyrilutamide from Koshine is different from Anageninc and if it's effective for hair loss. It also questions if sticking to RU58841 would be better.
A new hair loss treatment, Pyrilutamide, has been released and is claimed to be a strong anti-androgen, potentially effective when used with finasteride. However, there are mixed opinions on its effectiveness and safety, with some users skeptical and others purchasing it.
Kintor is testing Pyrilutamide with Minoxidil for hair loss. Users are skeptical about its effectiveness and concerned about limited treatment options if this fails.
The user discusses using Minoxidil for hair loss and is considering RU58841 to reduce excessive oil production. They seek advice on RU58841's effectiveness in blocking sebum production.
The conversation is about a user obtaining a compounded treatment for hair loss, including 0.1% latanoprost, 0.2% melatonin, and 1% cetirizine. The user also uses 2.5 mg dutasteride, 5 mg minoxidil, and RU58841 daily, and is at Norwood 2.
The conversation is about compounding topical cyclosporine for hair loss, suggesting it needs an oil base like castor oil. The user seeks tips or tricks for the process.
The user seeks alternatives to Propylene Glycol (PG) for delivering topical finasteride due to scalp irritation. They consider using Propanediol 1,3 and ask for other suggestions.
Potential treatments for hair loss, specifically the combination of liquid minoxidil and pyrilutamide, with some suggesting that adding finasteride may be beneficial.