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      community Anyone find results when finasteride failed?

      in General  110 upvotes 6 months ago
      The conversation discusses hair loss treatments, specifically the use of finasteride, dutasteride, and RU58841. The user is seeking alternatives after finasteride failed to stop hair loss, with suggestions to try dutasteride or consider RU58841 under caution.

      community RU55481

       4 upvotes 12 years ago
      The conversation discusses using RU58841, a research chemical, for hair loss treatment. The user plans to use it due to side effects from finasteride and minoxidil, despite skepticism about its effectiveness and lack of FDA approval.

      community When you pop your first Fin pill

      in Satire 5 years ago
      Hair loss treatment using Fin, Minoxidil and RU58841 with discussion about potential side effects and the power of nocebo effect.

      community A Technical Question About Pyrilutamide

      in Research/Science  5 upvotes 2 years ago
      Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

      community Massive shed coming back on minoxidil

      in Minoxidil  8 upvotes 9 months ago
      Stopping and restarting minoxidil can cause significant hair shedding. The user is also using finasteride and microneedling to manage hair loss.

      community I’m considering stopping finasteride

      in Finasteride/Dutasteride  157 upvotes 5 months ago
      The user is considering stopping finasteride due to depression, anxiety, and difficulty building muscle, despite its effectiveness in stopping hair loss. Suggestions include reducing the dose, switching to topical solutions, or consulting a doctor for alternatives like dutasteride or RU58841.

      community Thinking about RU58841

      in Treatment  4 upvotes 5 years ago
      OP experienced side effects from finasteride and is considering trying RU58841 for hair loss, while currently using minoxidil, Stemoxydine, a dermapen, and Nizoral. Another user shared positive results with RU58841, noting no side effects and maintained hair thickness after stopping its use.

      community fluridil (topilutamide) vs. cb-03-01 (clascoterone)

      in Research/Science  5 upvotes 2 years ago
      The conversation is about comparing the effectiveness of fluridil and clascoterone in preventing hair loss and inquiring about their use as standalone treatments. There is a question about the concentration of the fluridil brand for efficacy.

      community the "its so over / we're so back" pendulum

      in Chat  180 upvotes 1 year ago
      People with hair loss experience emotional struggles and body dysmorphia. Treatments like minoxidil, finasteride, and dutasteride are used, but results vary and can take time.

      community Dht kills hair, but no one says why?

      in Finasteride/Dutasteride  40 upvotes 9 months ago
      DHT affects hair follicles, contributing to hair loss, but the exact mechanism is unclear. Treatments like finasteride and minoxidil are used to manage hair loss, though they may have side effects and varying effectiveness.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Efficacy and Systemic DHT Suppression of Topical Finasteride vs Dutasteride

      in General  122 upvotes 1 year ago
      Topical dutasteride may have limited absorption due to its higher molecular mass compared to finasteride, potentially affecting its efficacy in suppressing DHT locally. Microneedling might enhance dutasteride absorption, possibly offering stronger local DHT suppression with fewer systemic effects.

      community RU58841 and Min - topical 50 mg each day

      in Progress Pictures  6 upvotes 2 years ago
      The conversation is about a person's hair improvement after 14.5 months using RU58841 and Minoxidil topically at 50 mg each day, with noticeable hairline improvement but incomplete crown area recovery. The person struggles to take good pictures of their crown area.

      community 5-year Minoxidil user quitting after minor heart attack

      in Minoxidil  5 upvotes 5 years ago
      A user experienced a minor heart attack after combining minoxidil with dermarolling and is considering stopping minoxidil use. They are concerned about hair loss after quitting and are exploring if finasteride or essential oils can maintain hair growth.

      community Minoxidil night time application

      in Treatment  2 upvotes 3 months ago
      Apply minoxidil at least 1-2 hours before bed to ensure it dries and doesn't transfer to the pillow. Foam dries faster than liquid, and using a satin beanie after drying can help prevent transfer.

      community Any experiences with Ptd-dbm??

      in Research/Science  5 upvotes 2 weeks ago
      The user experienced reduced hair loss using an online serum but found it too expensive and is seeking a vendor for ptd-dbm. They are also interested in KY19382 but are unable to find it.

      community Pyrilutamide cease and desist from Kintor

      in Transplants  12 upvotes 3 years ago
      Considering a hair transplant, using Pyrilutamide, the potential availability of CosmeRNA, and the significance of taking Minoxidil and Finasteride for long-term results.

      community Sensitive to Oral fin + RU. Am I screwed?

      in Product  5 upvotes 4 years ago
      Akinfenrawr experienced negative side effects from oral finasteride and RU58841, and is seeking alternative hair loss treatments. They discuss various options, including raloxifene, oral dutasteride, liposomal finasteride, Breezula, Pyrilutamide, SM04554, and sulforaphane, but have concerns about efficacy, availability, and cost.

      community Combine minoxidil, tazarotene, lumigan

      in Treatment  3 upvotes 10 months ago
      Combining minoxidil 5%, tazarotene 0.1% cream, and lumigan for hair loss treatment is discussed. The conversation focuses on the safety and effectiveness of using these treatments together.