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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Capilia Longa and scandinavian biolabs

      in Research/Science  2 upvotes 3 years ago
      Capilia Longa and Scandinavian Biolabs are discussed, with skepticism about their effectiveness and value. The conversation suggests avoiding these products due to high cost and perceived lack of results.

      community Losing the genetic lottery - venting

      in Chat  67 upvotes 2 months ago
      The user is experiencing hair loss and has tried various treatments including topical and oral finasteride, minoxidil, dutasteride, and ketoconazole, but continues to lose hair. They are considering alternative solutions like hair systems due to the lack of improvement and a scalp condition called CVG.

      community Any experience with Laduora massage brush

      in Technology  3 upvotes 1 year ago
      The conversation is about the effectiveness of the Laduora duo massage brush for hair regrowth using vibration and red light, and whether the vitamin gel pods make sense. Specific treatments like Minoxidil, finasteride, and RU58841 are not mentioned.

      community Is .5% kx-826 worthless? Koshine vs RU

      in Research/Science  3 upvotes 1 year ago
      Kx-826 at 0.5% shows limited effectiveness for hair loss, while 1% is more promising but expensive. RU58841 is considered a more feasible option until 1% kx-826 becomes affordable.

      community Bloodwork Results. DHT and Testosterone Levels

      in Update  6 upvotes 2 years ago
      The user shared their bloodwork results showing DHT at 17 ng/dl and testosterone at 287 ng/dl, with a slight Vitamin D deficiency. They are seeking opinions on these levels and have an upcoming dermatologist appointment.

      community How to source winlevi? Not generica

      in Product  1 upvotes 2 months ago
      The conversation is about sourcing Winlevi (clascoterone) for personal use in the EU. The user is specifically looking for a non-generic version.

      community Is it possible to have low scalp vascularity??

      in Treatment  3 upvotes 2 years ago
      The user is using topical dutasteride, finasteride, minoxidil, and tretinoin but seeing no results or side effects. They also microneedle every two weeks but experience little bleeding, questioning if a thick scalp is preventing treatment effectiveness.

      community My Vitamin D (25-0H) levels came <4.20 ng/ml (<20 implies deficiency)and B12 came 184 pg/ml (Should be between 211-911). I have a lot of dandruff. The derm has prescribed me with 60k vitamin d tablet once a week and multivitamins for a month. Vitamin deficiency implies TE no? or is it MPB?

      in Treatment  38 upvotes 4 years ago
      The conversation discusses hair loss treatments, focusing on vitamin D and B12 deficiencies, and mentions using finasteride. It also suggests getting a biopsy to differentiate between MPB and other conditions.

      community Lysine IS helping

      in Update  4 upvotes 5 years ago
      Lysine supplementation at 2 grams daily reduced hair shedding by 25% and made hair strands thicker. The user highly recommends lysine for hair health.

      community making a clascoterone lotion from powder

      in Technology  2 upvotes 1 year ago
      A user is considering making a 2% clascoterone lotion from powder due to unavailability in their location. They plan to mix clascoterone powder with retinol lotion and use literature to determine the correct dosage.

      community Winlevi (clascoterone) for hairloss?

      in Treatment  1 upvotes 11 months ago
      Winlevi (clascoterone), a DHT blocker, is being considered for hair loss treatment, though it's primarily an acne medication. Users discuss its potential effectiveness and note it may only work for a short time.

      community One month in, and LLLT is seemingly working

       4 upvotes 9 years ago
      The user experienced hair loss possibly due to scalp damage and tried natural treatments with limited success. They reported noticeable hair thickening after using a laser treatment device, suggesting it may be effective, especially for those on finasteride.

      community the post about vitamin c and pH levels is legit.

      in Update  12 upvotes 4 years ago
      Using vitamin C in shampoo to adjust pH levels can improve hair health and reduce oiliness and dandruff. The user mixed vitamin C powder with conditioner, achieving positive results.

      community FLEAVA are scammers! Buyer beware

      in Product  4 upvotes 10 months ago
      FLEAVA is accused of scamming customers by enrolling them in unwanted monthly subscriptions for Advanced Copper Peptide without consent. Many users struggled to get refunds and reported ongoing charges despite cancellation requests.

      community RU-58441 Janoshik test result of Made-In-China Supplier

      in Product  27 upvotes 7 months ago
      A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

      community Anger and frustration as I finally learn my diagnosis.

      in Female  6 upvotes 2 years ago
      A young female diagnosed with Lichen planopilaris (LPP) experienced years of misdiagnosis and ineffective treatments, including a hair transplant and other procedures. She is considering litigation due to the misdiagnosis and has learned that LPP is chronic, hair loss can be stopped with ongoing medication, but lost hair cannot regrow.

      community Low Level Laser Cap has been effective for me

      in Technology 2 years ago
      A user reported positive hair growth using a regimen of oral finasteride, minoxidil, Dr. Pen, keto shampoo, and a Capillus 272 LLLT cap. Other users debated the effectiveness of the LLLT cap, with some attributing the success to the combined treatments rather than the cap alone.

      community Red light therapy - research says they work, reviews say they don't - Turns out commercial device are severely under-powered, so could this actually work?

      in Technology  73 upvotes 2 years ago
      The conversation discusses the effectiveness of commercial Low-Level Laser Therapy (LLLT) devices for hair growth, suggesting they are underpowered compared to the ideal energy output shown in medical research. A user plans to build a custom helmet that meets the required specifications for effective treatment.

      community Anyone with LPP have regrowth with Xeljanz?

      in Treatment  3 upvotes 1 year ago
      The conversation is about using Xeljanz for hair regrowth in individuals with LPP. The user is seeking experiences and expectations from others who have tried this treatment.

      community Winlevi coming out in 2019

       13 upvotes 7 years ago
      The conversation discusses the potential release of Winlevi in 2019 by Cassiopeia for hair loss treatment. It suggests a regimen combining minoxidil, Winlevi, Nizoral, and possibly dermarolling, with a comment mentioning Breezula as an alternative to finasteride without side effects.

      community VDPHL01 works really quickly .. apparently?

      in Research/Science  48 upvotes 3 months ago
      VDPHL01 shows faster and stronger hair growth compared to standard minoxidil, with no major side effects reported. Users discuss combining it with other treatments like dutasteride and finasteride for better results, while expressing skepticism about the effectiveness of PP405.