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      community Upcoming and current hair growth stimulants (2026)

      in Research/Science  94 upvotes 4 months ago
      The conversation discusses various hair growth treatments, including topical and oral minoxidil, microneedling, LLLT, PRP, exosomes, latanoprost, copper peptides, and upcoming treatments like PP405 and Vdphl01. It also covers managing side effects of minoxidil, such as dry scalp, and mentions the use of dutasteride and finasteride for hair loss.

      community Hair Loss Inflammation Prevention Stack

      in Research/Science  46 upvotes 1 year ago
      The conversation discusses a hair loss and scalp care routine involving ciclopirox shampoo, benzoyl peroxide, clindamycin gel, clobetasol propionate, and calcipotriol to manage seborrheic dermatitis, folliculitis, and inflammation. It also touches on the role of diet and other treatments like oral minoxidil and pioglitazone for scalp health.

      community Not sure but Lipogaine seems like its working

       4 upvotes 13 years ago
      A user experienced significant hair regrowth using Lipogaine, alongside supplements, coffee, green tea, onion oil, rosemary, and Nizoral shampoo, after Propecia caused side effects. Another user reported no progress with Lipogaine after two months, noting inconsistent application.

      community P-1075: a BETTER version of Minoxidil

      in Research/Science 8 months ago
      P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

      community So Pyrilutamide has been postponed by one year. How likely is that to happen to GT20029

      in Treatment  27 upvotes 2 years ago
      The conversation discusses the delay in the release of a new hair loss treatment, Pyrilutamide, and speculates on potential safety concerns as a reason for the delay. It also mentions GT20029 as another future treatment option, with a release at least five years away, and touches on the avoidance of research chemicals due to uncertainty about their authenticity.

      community Pelage Recruiting Now for Phase 2

      in Research/Science  11 upvotes 2 years ago
      Pelage is recruiting for phase 2 trials, showing promise for treating bald regions. The discussion highlights its potential effectiveness based on its mechanism of action.

      community Do we have anything in the pipeline that is used as a replacement for minoxidil?

      in Minoxidil  17 upvotes 1 year ago
      The conversation discusses hair loss treatments, focusing on alternatives to Minoxidil, such as Bimatoprost and Latanoprost, and the use of Finasteride, Dutasteride, RU58841, and microneedling. The user plans to add Latanoprost to their regimen, which already includes oral and topical Minoxidil and Finasteride, Ketoconazole shampoo, and microneedling.
      Can liver problems be associated with response to the oral minoxidil?

      community Can liver problems be associated with response to the oral minoxidil?

      in Research  147 upvotes 5 months ago
      Liver problems may reduce the effectiveness of oral minoxidil due to impaired SULT1A1 enzyme activity, which is crucial for converting minoxidil to its active form. This reduction in enzyme function can significantly decrease the drug's effectiveness in promoting hair growth.

      community What's your thoughts on Pyrilutamide

      in Product  5 upvotes 6 months ago
      The conversation is about using pyrilutamide and RU58841 as topical solutions to prevent hair loss. Pyrilutamide is considered safer but less potent than RU58841, which some users find effective despite potential side effects like heart palpitations.

      community Pelage are starting phase 3 for PP405 towards the end of 2026

      in Chat  180 upvotes 4 months ago
      PP405 is moving to late-stage trials, showing potential for hair regrowth, with 31% of male patients experiencing a 20% increase in hair density. Veradermics is developing an oral minoxidil version, and there is interest in combining treatments for better results.

      community Hair Regrowth Protocol for the Brothers suffering

      in Treatment  57 upvotes 2 years ago
      The conversation discusses a hair regrowth protocol involving Dutasteride, Pyrilutamide, Stemoxydine, Minoxidil, Tretinoin, Oral Castor Oil, and L-Carnitine L-Tartrate. Some users are skeptical, particularly about the effectiveness and side effects of oral castor oil.

      community Thinking about my making own CB-03-01 (Breezula). Thoughts?

      in Treatment  6 upvotes 5 years ago
      The user experienced side effects with both oral and topical finasteride and is considering making their own hair loss treatment using CB-03-01 (Breezula) mixed with minoxidil due to fewer reported side effects. They plan to use a lower concentration than what was used in trials.

      community New regimen started after 4 years of little progress

      in Treatment  5 upvotes 3 years ago
      The user is trying a new hair loss regimen including Spirolactone, Finasteride, oral Minoxidil, microneedling, and various supplements. They are experiencing increased shedding and seeking advice on microneedling and treatment effectiveness.

      community Kintor Pharmaceutical Announces AR-PROTAC (GT20029) Approved for Acne and Androgenic Alopecia Clinical Trials in China

      in Technology  13 upvotes 5 years ago
      The conversation discusses the approval of Kintor Pharmaceutical's AR-PROTAC (GT20029) for clinical trials in China for acne and androgenic alopecia. One user expresses optimism about new treatments being developed and seeks clarification on how the new drug works, specifically if it temporarily degrades the AR protein to reduce DHT sensitivity in hair follicles.

      community M27 Fin/Min (topical) was fun while it lasted

      in Finasteride/Dutasteride  20 upvotes 1 year ago
      The user experienced high liver enzyme levels, possibly due to topical finasteride or supplements, and decided to stop using finasteride while continuing minoxidil. After stopping finasteride and supplements, liver levels returned to normal, suggesting finasteride or supplements might have been the cause.

      community Lets do this!!! My current Stack

      in Treatment  4 upvotes 1 year ago
      The conversation discusses a hair loss treatment regimen using Alfatradiol, Pyrilutamide, and Minoxidil. The user shares their current stack of these treatments.

      community New Hair Loss Cure: AMP-303 Is Back. It’s what PP405 should have been.

      in Research/Science  5 upvotes 3 months ago
      AMP-303 and AMP-601 are new hair loss treatments targeting dermal papilla cells, with AMP-303 showing early efficacy in transitioning vellus hairs to terminal hairs after one injection. Further clinical trials are planned, and these treatments are seen as promising due to their biologic approach and less frequent application compared to daily treatments.

      community A vehicle for powdered melatonin

      in Treatment  6 upvotes 4 years ago
      The conversation is about using topical melatonin for hair loss and seeking advice on a safe mixing solution or pre-mixed product. Specific treatments mentioned are minoxidil, finasteride, and RU58841.

      community 5 months topical spiro + minox + micro

      in Progress Pictures  6 upvotes 1 year ago
      A 35-year-old male uses topical minoxidil, spironolactone, and microneedling for hair loss, with spironolactone prescribed based on a DNA test indicating poor response to finasteride and dutasteride. Despite concerns about the test's validity and spironolactone's side effects, he reports stable or improved hair condition and no low testosterone symptoms.

      community Does CosmeRNA target the root cause of MPB?

      in Chat 3 years ago
      . CumsOnYourFeet69 has been discussing a new treatment called CosmeRNA which claims to target the root cause of male pattern baldness, and is considering using it in conjunction with Minoxidil instead of Finasteride due to possible side effects. Replies have highlighted that the efficacy of this treatment is still unknown, but it could be used as an effective maintenance option if successful.

      community Pyrilutamide 4 Month Journey with progress Pics..!!!

      in Progress Pictures  21 upvotes 11 months ago
      The user reported significant hair regrowth and stopped hair loss after using Pyrilutamide and Minoxidil for four months. They found Pyrilutamide effective in blocking DHT locally without side effects, preferring a gray market version over Koshine's product.