PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hairfollicle stem cells and increase hair growth by 20% in eight weeks, unlike minoxidil or finasteride. However, skepticism remains about its effectiveness and availability, with concerns about funding and the timeline for broader access.
The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hairfollicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hairloss.
A 32-year-old male with Norwood 3 and heavy diffuse thinning is starting a hairloss treatment including RU58841, Minoxidil, finasteride, derma rolling, vitamins, and possibly MK677, while cutting out most sugars from his diet. He plans to share progress photos and updates on his test levels.
The conversation discusses expectations for the release of Breezula, a new hairloss treatment, and compares it to existing treatments like finasteride. Some believe Breezula could be a game-changer due to fewer side effects, while others await more permanent solutions like hairfollicle cloning.
The user reported healthier, firmer, and thicker hairfollicles with minimal regrowth at the front after using Regenera Activa, topical finasteride, minoxidil, tretinoin, caffeine solution, and vitamin D supplements. Hairloss has stabilized with no side effects.
A 31-year-old male with low normal-range testosterone and DHT is experiencing significant hairloss from the front scalp. He has tried Minoxidil, vitamin D3 and B12 supplements, and exercises regularly but is still seeking the root cause and effective treatment.
The user "Curious_Conflict_959" shared a progress picture of their hair transplant after 5 months. They used a low dosage of RU on native hairs and had PRP treatments. All hairloss has stopped.
Minoxidil increases blood supply to the scalp, strengthening dormant follicles and extending the growth phase, but may increase scalp activity that can be countered with DHT blockers. Women experiencing side effects from finasteride or dutasteride for hairloss might consider alternatives like estrogen, especially if on birth control.
Oral minoxidil is more effective than topical for hair regrowth but may cause unwanted body hair growth and cardiovascular side effects. Some users experience positive results, while others discontinue use due to side effects like chest pain.
Balding scalps have more androgen receptors, leading to increased TGF-beta, which causes blood vessel loss and hairfollicle miniaturization. Blocking androgen signaling and TGF-beta may help prevent hairloss.
The conversation is about foods, vitamins, and supplements to avoid to prevent hairloss, specifically mentioning alcohol, Brazil nuts, smoking, and sugary foods.
The conversation discusses CRISPR-on & CRISPR-off as a potential cure for baldness, contrasting it with hair cloning and other treatments like Minoxidil, finasteride, and RU58841. It also mentions the potential of mRNA for gene expression control and the prioritization of gene editing for severe genetic conditions.
A 25 year old male who has been using finasteride and dutasteride for two years to treat his hairloss, with no success. Other treatments such as oral minoxidil, topical anti-androgens, RU58841, latanoprost, topical estrogen, CB 03 01, microneedling, keto 2% shampoo, vitamin D, Omega 3, B vitamins and probiotics were discussed.
Scientists discovered a sugar gel, 2dDR-SA, that increased hair growth in mice. Users discussed its potential, comparing it to other treatments like Minoxidil and finasteride.
A user reported hairline regrowth after two weeks on a treatment including finasteride, peppermint and rosemary oils, emu oil, magnesium oil spray, apple cider vinegar, and dermarolling, while avoiding shampoos and conditioners. They believe DHT contributes to hairloss but also suggest follicle fibrosis is an issue.
Finasteride, dutasteride, and minoxidil are discussed as treatments for male pattern baldness. Finasteride and dutasteride are effective DHT blockers, while minoxidil is necessary for regrowth but must be used consistently.
User has been on finasteride and switched to Dutasteride 6 months ago, using minoxidil, tretinoin, microneedling, and RU-58841, but still experiencing hairloss. Advice given includes waiting 6-18 months for Dutasteride results and checking if it's definitely MPB.
Hairloss discussion includes treatments like Minoxidil, Finasteride, and RU58841. A secret to applying Toppik Hair Building Fibers is shared, and a possible reason is to help people apply Toppik.
Hairloss without a white bulb may indicate mechanical damage, anagen effluvium, alopecia areata, or traction alopecia. Seeking a specialist is recommended, but access can be difficult in smaller areas.
The conversation is about the effects of steroids on hairloss. Some users believe that steroids can cause hairloss, while others argue that it depends on individual sensitivity to DHT. There is also discussion about the appearance of balding individuals who use steroids.
Exosome injections stimulate hair growth by using exosomes' healing potential to awaken dormant hairfollicles and promote new hair cell creation. The procedure increases scalp blood circulation, encourages collagen and elastin formation, and regenerates hairfollicles, improving hair thickness and quality.
A breakthrough in hairfollicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hairfollicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.
The conversation discusses hairloss treatments, specifically Brassica oleracea extract, glucosinolates, and sulforaphane, and their potential to promote hair growth. Users also mention minoxidil and finasteride as existing treatments.
To minimize hairloss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.
Tazarotene shows potential as a standalone treatment for hair regrowth by stimulating new hairfollicle formation and promoting angiogenesis, similar to microneedling effects. It can be used topically without minoxidil, but users should start with a low concentration to avoid irritation.
The user is using RU58841, finasteride, dutasteride, and minoxidil to slow down aggressive hairloss but is still experiencing hair shedding due to high testosterone levels. They plan to use ostarine to lower testosterone and prevent hairloss while maintaining muscle mass, and will continue using the other treatments.
Microneedling should target depths of 0.5mm to 1.5mm for hairloss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.