PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.
A 32-year-old male with diffuse thinning and seborrheic dermatitis has been using finasteride for 8 months without improvement. He is considering COQ10 + PQQ supplements for scalp inflammation and hair loss.
The user reported subtle hair regrowth by focusing on scalp health and lifestyle changes, using Nizoral shampoo and methods to reduce inflammation and cortisol, without using finasteride, minoxidil, or other common treatments. Opinions in the conversation varied, with some skeptical of the results and others acknowledging the potential benefits of addressing scalp health and inflammation.
The conversation discusses using brewer's yeast for hair regrowth, either as a supplement or in a scalp masque. The user is considering adding it to their regimen.
A satirical discussion about a hair transplant, with humorous comments on graft placement and clinic choice. The conversation includes references to a "Rebuild a Scalp Clinic" and jokes about using pubic hair and overharvesting.
The conversation humorously discusses using a full head wig for hair, beard, and perfect skin, with mentions of treatments like finasteride, RU58841, and microneedling. It highlights a shift from serious hair loss discussions to satire and memes.
Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.
Dutasteride and high-dose Minoxidil are the primary treatments maintaining hair, with additional supplements and therapies like red light offering minimal extra benefit. The discussion criticizes promoting expensive hair care products when basic medications are doing most of the work.
The conversation is about hair loss and the effectiveness of treatments like finasteride, with one user expressing satisfaction after seeing hair regrowth on CCTV. Other users share their experiences with hair visibility and discuss the effectiveness of finasteride compared to dutasteride.
A humorous discussion about a scalp massager used in a barber shop, with no mention of specific hair loss treatments like Minoxidil, finasteride, or RU58841. The massager is described as pleasurable but not a treatment for hair loss.
The conversation discusses potential advancements in two hair loss drugs, KX-826 and GT20029, and the interest in whether transitioning from oral finasteride to these drugs would maintain hair growth. One reply expresses skepticism about the compounds' representation.
A user proposed genetically engineering scalp stem cells to stop androgen receptors from causing hair loss. Others discussed the feasibility, existing research, and potential issues with this approach, including targeting the correct cells and unintended effects.
A user is interested in seeing scalp tattoos as a response to hair loss, specifically looking for creative designs rather than scalp micropigmentation. They are considering this approach for their own Norwood 5 hair loss situation.
PP405 may induce new hair growth but cannot revive completely dead follicles, and its effectiveness on hairlines is uncertain. It is expected to be available by mid-2028, but users are advised to manage expectations and consider using other treatments like minoxidil and finasteride.
PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.
The user is stressed about hair loss and is using a HIMS topical treatment containing finasteride, ketoconazole, minoxidil, and biotin, but is concerned about the oily appearance it causes. They are considering switching to Rogaine (minoxidil) due to budget constraints and side effect concerns with oral finasteride.
The user experienced significant hair regrowth using finasteride, minoxidil, and a 4,000-graft hair transplant performed by Dr. Nader in Reynosa, Mexico. The results were natural-looking, and the user plans a second transplant for additional density if needed.
Matthew McConaughey's hair restoration methods are speculated to involve hair systems, transplants, and treatments like finasteride and minoxidil. Many believe he falsely credits his hair regrowth to Regenix, while others suggest he uses a combination of treatments for a natural look.
Adding non-prescription topicals like alfatradiol and Zix to a standard fin/min/niz regimen may help with scalp inflammation and shedding, but their long-term effectiveness varies. Zix is recommended for reducing scalp inflammation and enhancing the effectiveness of other treatments.
Some users believe creatine may accelerate hair loss, while others see no effect. Opinions are mixed, with some suggesting using treatments like finasteride to counter potential effects.
The user shares their hair loss treatment routine, which includes topical minoxidil, botana oil, coconut moisturizer, derma stamping, derma rolling, 3% salicylic acid shampoo, and scalp massage. Suggestions include adding finasteride, switching to 2% ketoconazole shampoo, and using rosemary oil instead of botana oil.
The conversation is about finding a pure high molecular weight hyaluronic acid for the scalp after microneedling. A user suggests using a product from The Ordinary.
A 33-year-old male restarted finasteride after stopping it to conceive, noticing hair loss, especially in the crown area. His current routine includes finasteride, minoxidil, ketoconazole, and microneedling, and he plans to continue this treatment for 18 months before making any major changes.
The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, and RU58841, and highlights hair multiplication research from Koehler Lab at Harvard. Users express optimism about future advancements.
The user is experiencing severe hair shedding while on finasteride and plans to start using ketoconazole shampoo to address a greasy, waxy scalp buildup. They are seeking additional advice for managing hair loss.
A user was prescribed betamethasone dipropionate spray for a receding hairline, which caused skin peeling and depigmentation. They stopped using it and are considering alternatives like BPC-157/TB-500 for healing.
Beard to scalp hair transplants can provide 12,000-15,000 grafts for coverage, with fast recovery time. However, beard hair may grow curly and not suitable for frontal areas.
Stem-cell hair transplants could potentially create thousands of grafts from a single donor graft, offering a solution for hair loss with DHT-resistant hair. Companies like Stemson Therapeutics and OrganTech are working on this technology, which may become available in the future, possibly reducing the cost and making it widely accessible.
A user named Mmherak is experiencing hair loss, with low B12 and iron deficiency, and has been recommended minoxidil and spironolactone by dermatologists. Other users suggest seborrheic dermatitis or dandruff, recommending treatments like Nizoral shampoo, ketoconazole, and Selsun Blue.