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      35M: Irregular Fin Use, Seeking Alternatives to Minoxidil and Fin

      community 35M: Irregular Fin Use, Seeking Alternatives to Minoxidil and Fin

      in General  57 upvotes 10 months ago
      A 35-year-old male has been using finasteride inconsistently for two years and is hesitant about using minoxidil due to potential side effects. He is considering oral minoxidil and microneedling as alternatives and is unsure if dutasteride is too strong.
      Eliminate/Confirm AGA based on blood report

      community Eliminate/Confirm AGA based on blood report

      in General  126 upvotes 11 months ago
      A 19-year-old male with no family history of androgenetic alopecia (AGA) is experiencing hair loss and considering using a topical minoxidil and finasteride mixture. Despite low vitamin D levels and normal DHT serum levels, he seeks confirmation of AGA before starting treatment.

      community My personal experience/observations fighting AGA seriously for 5 years

      in Treatment  47 upvotes 1 year ago
      Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.

      community Pyrilutamide is literally my only hope

      in Chat  91 upvotes 3 years ago
      Considering treatments for hair loss, including Minoxidil, Finasteride, RU58841, Fluridil and Pyrilutamide. The user is weighing the risks of taking unapproved medication before it has been mass produced.

      community The cure we've been ignoring: Anal Dutasteride

      in Satire  224 upvotes 1 month ago
      The conversation humorously discusses using anal administration of Dutasteride as a novel method for treating hair loss, suggesting it could target DHT production more effectively. It includes satirical comments about the method's potential effects and absurd outcomes.

      community Is this solution unnecessarily aggresive?

      in Product  2 upvotes 5 months ago
      The solution contains minoxidil, finasteride, azelaic acid, caffeine, retinoic acid, and procapil. Users suggest minoxidil with tretinoin and a 5-alpha reductase inhibitor, while dismissing retinoic and azelaic acids as unnecessary.

      community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

       22 upvotes 6 years ago
      A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

      community 28M 5MG MIN 0.5MG DUT - CROWN FILLING IN

      in Progress Pictures  375 upvotes 1 month ago
      A 28-year-old male reported significant hair regrowth using 5mg minoxidil and 0.5mg dutasteride over five months, with occasional ketoconazole use. Users discussed side effects like stuffy nose and low libido, and shared experiences with different hair loss treatments.

      community Trichotest Results: no Finasteride

      in Finasteride/Dutasteride  5 upvotes 4 years ago
      The user received trichotest results indicating finasteride is ineffective for them, and they plan to use dutasteride mesotherapy and add cetirizine to minoxidil. They seek advice on incorporating dutasteride into their regimen.

      community What do we actually know about HMI-115?

      in Chat  16 upvotes 2 years ago
      The post and conversation are about HMI-115, a potential treatment for hair loss. The conclusion is that HMI-115 is not a 5ar-inhibitor and is instead a prolactin receptor inhibitor. Some users are skeptical about its effectiveness and believe that baldness will still be a problem in the future.

      community M35 - Oral fin 0.4mg, Mix 1.0mg - 3 month progress

      in Progress Pictures  249 upvotes 2 years ago
      A man, 35, shows 3-month hair regrowth progress using 0.4mg oral finasteride, 1.0mg minoxidil, topical minoxidil once daily, weekly dermastamping at 1.5mm, and ketoconazole shampoo. He experienced initial worsening, has no side effects, and received positive feedback on his early results.

      community Rosemary oil, peppermint oil, mucuna pruriens - two weeks in

      in Treatment  83 upvotes 3 years ago
      A user who is trying alternative treatments, such as mucuna pruriens dissolved in water/alcohol and a blend of jojoba oil, rosemary oil, and peppermint oil, for hair loss. Other users have shared anecdotal evidence, discussed the potential effectiveness of certain treatments, and questioned the time sensitivity of experimenting with new treatments.

      community Cheaper alternative to Roman spray?

      in Product  2 upvotes 1 year ago
      A user has had great results with a spray containing 6% minoxidil, 0.03% finasteride, and 0.25% tretinoin from Roman but is seeking cheaper alternatives with the same ingredients. They are looking for suggestions for more affordable sites or pharmacies.

      community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

      in Research/Science  5 upvotes 4 months ago
      Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

      community KX-826 Pyrilutamide1% coming soon

      in Update  152 upvotes 1 year ago
      KX-826 Pyrilutamide 1% is launching soon, and users are discussing its potential benefits and drawbacks compared to other treatments like Minoxidil and finasteride. Some users are skeptical about its effectiveness, while others are hopeful it will be a safer alternative.

      community Finally live! alcohol-free, propylene glycol–free topical finasteride foam

      in Update  15 upvotes 7 months ago
      A new alcohol-free, propylene glycol-free topical finasteride foam is available for prescription in Canada and the USA, offering a cleaner alternative for hair loss treatment. The product also offers a combination of 0.1% finasteride with 5% minoxidil and aims to be affordable and less irritating for sensitive scalps.

      community Targeting multiple AGA mechanisms with commonly available substances

       4 upvotes 7 years ago
      The conversation discusses using a multimodal approach to treat androgenic alopecia, including substances like gamma-linolenic acid, DHA, sulforaphane, melatonin, cetirizine, astaxanthin, fisetin, apigenin, curcumin, limonene, genistein, and berberine. Users also mention using ketoconazole, minoxidil, and low-level laser therapy (LLLT) as part of their hair loss treatment regimens.
      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 9 months ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

      community Which mesotherapy should I choose?

      in Research/Science  1 upvotes 2 years ago
      A user is considering adding PRP and mesotherapy to their hair loss treatment and is deciding between two options: Promoitalia, which contains Phosphatidic acid, Riboflavin, and Superoxide dismutase, and the more expensive Melsmon, a human placenta derivative. They seek advice on which option to choose based on effectiveness and scientific backing.

      community Does melatonin dissolve in isopropyl alcohol

      in Technology  7 upvotes 3 years ago
      The conversation discusses making a topical melatonin solution for hair loss treatment, questioning if isopropyl alcohol can dissolve melatonin. Melatonin is soluble in lipids and alcohol, but it's unstable and should be mixed fresh regularly; it may help hair growth by affecting certain cellular signaling pathways and has anti-androgenic effects.