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community Fluridil downregulates androgen receptor expression?

in Research/Science 1 upvotes 2 years ago

Fluridil may decrease the number of androgen receptors in hair follicles by up to 95%. This suggests a different action mechanism from other non-steroidal antiandrogens like RU58841, indicating they might be used together.

community Why TDM-105795 is not much talked about like GT20029 and HMI 115 despite having far better Trial results?

in Research/Science 33 upvotes 1 year ago

TDM-105795 showed better efficacy and safety in trials for hair loss, with a higher hair count improvement compared to GT20029 and HMI 115, but it's not as widely discussed. The user is questioning why this is the case.

community TWIST-1 and the cure: Is it really that easy?

in Research/Science 283 upvotes 3 years ago

TWIST-1 gene's role in hair loss and potential as a treatment target. Inhibiting TWIST-1 may prolong hair growth and reduce hair follicle sensitivity to DHT.

community 1.1 on fin and 1.5 on minox. Micro needling 2 months.

in Progress Pictures 39 upvotes 2 years ago

The conversation discusses a person's hair loss treatment over 1.1 years with finasteride, 1.5 years with minoxidil, and 2 months of microneedling, noting less shedding since starting vitamin D3 a month ago. Commenters are impressed with the results.

community 5 months on 5% min + 1 mg finastreride.

in Minoxidil 1096 upvotes 3 months ago

A user shared their experience using 5% minoxidil twice daily, 1 mg finasteride daily, and weekly derma stamping for hair loss, noting no crown thinning but front diffuse thinning and hairline issues. They experienced fewer side effects on 0.5 mg finasteride but returned to 1 mg, and did not experience shedding after starting treatment.

community 3.5 months progress - hairline

in Progress Pictures 88 upvotes 2 years ago

The user stopped using topical minoxidil and finasteride after 2.5 months and switched to oral finasteride, 1mg daily, and did microneedling 1.5mm seven times. They experienced occasional sleep issues and watery semen as side effects, which stopped after discontinuing the topical treatment.

community EMA is re-examining Winlevi (clascoterone at lower concentration)

in Treatment 8 upvotes 9 months ago

Clascoterone in Winlevi, a topical AR antagonist, is being re-examined due to concerns about HPA axis suppression in adolescents, but it's unlikely to be banned for adult use in androgenetic alopecia (AGA). The European Medicines Agency recommended refusing Winlevi for acne vulgaris, but this may not affect Breezula's approval for AGA.

community I need help. I’m 21M and doing PRP Treatment and Finasteride

in Is this regrowth? 1 upvotes 4 months ago

A 21-year-old male is experiencing hair thinning and has undergone PRP treatment while considering finasteride but is concerned about its side effects. A user suggests that PRP is ineffective without finasteride and advises against using biotin.

community (Serious) Updates and discussion, new treatments in development

in Treatment 7 upvotes 1 year ago

Finasteride, minoxidil, and derma rolling are currently the best treatments for hair loss. New treatments like TDM-105795, GT20029, PP405, HMI 115, Tsuji, Scube 3, RU, JW0061, Topilutamide, and verteporfin show promise but have uncertain timelines.

community M18: I think microneedling is making my hair look thinner

in Is this regrowth? 9 upvotes 1 year ago

The conversation is about a user experiencing hair thinning potentially due to excessive microneedling while using finasteride and minoxidil. Many suggest reducing microneedling frequency and considering alternative treatments like dutasteride or a hair transplant.

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