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180-210 / 1000+ resultscommunity Diffuse thinning is so fucked. Change in my from March til now
The user experienced significant hair thinning despite using finasteride and minoxidil, leading to concerns about whether it's a temporary shed or a more serious issue. They plan to start using RU58841 and are advised to consult a doctor to rule out other causes like autoimmune disorders.
community 5 months no fin or min just copper peptides and nad+
community 30M Experiencing Shedding After Restarting Min + Fin + Mesotherapy, Is It Too Late?
A 30-year-old is seeking advice on hair loss treatment, currently using oral minoxidil, finasteride, mesotherapy, and a supplement. They are experiencing shedding and are anxious about the effectiveness of the treatment, asking if they should continue or consider other options like topicals or microneedling.
community Heavy shedding about 1 year into fin and min (diffuse thinning)
The user experiences heavy shedding after one year of using 1mg oral finasteride and twice-daily topical minoxidil, recently adding microneedling and daily Nizoral. They also take supplements like vitamin D and biotin.
community A New Therapeutic Channel to Come Soon: Hair Follicle Sugar Metabolism and Aldose Reductase
Hair loss therapies focusing on hair follicle sugar metabolism and aldose reductase. Potential treatments include magnesium supplements, avoiding high glycemic index foods, and antioxidants.
community AA and Hirsutism but T levels are normal
27-year-old female experiences aggressive hair thinning and hirsutism despite normal testosterone levels. Spironolactone and 2% minoxidil were ineffective; high DHEA sulfate levels may be the cause.
community Pelage are starting phase 3 for PP405 towards the end of 2026
PP405 is moving to late-stage trials, showing potential for hair regrowth, with 31% of male patients experiencing a 20% increase in hair density. Veradermics is developing an oral minoxidil version, and there is interest in combining treatments for better results.
community Will Pelage include Norwood 7 hair loss in PP405 phase 3 trials to see its true regenerative potential?
Norwood 7 hair loss is often excluded from trials to ensure treatments appear more effective and to reduce costs. Some believe treatments effective for Norwood 5 could work on Norwood 7, but companies prioritize market readiness.
community Why does MPB only affect the scalp
Male pattern baldness (MPB) may be influenced by androgen receptors in scalp hair follicles and potentially poor blood flow. Transplanted hair is not immune to DHT, and factors like inflammation and scalp tension might also contribute to hair loss.
community Has anyone experienced burning scalp after chemical damage (perm)?
A user experienced burning, itching, and soreness on their scalp after a perm in 2021, despite using oral finasteride, oral minoxidil, and ketoconazole shampoo. They are seeking advice on whether to pursue further medical tests or consult a neurologist for nerve pain.
community Why Diffuse Thinning is Worse Than a Receding Hairline
Diffuse thinning is worse than a receding hairline as it affects the entire scalp, complicating styling and hair transplants. Treatments like finasteride, minoxidil, dutasteride, and RU58841 are mentioned, with some users noting improved hair density.
community 6.5 Month Progression 33/Female
Maintaining scalp hair and minimizing shedding, treatments used such as Procapil, supplements, topical caffeine, topical estrogen, and scalp massage; suggestions for anagen extenders or pharmaceuticals to help with a short anagen phase.
community Is it Ritalin? (23 F)
A user suspects Ritalin is causing hair loss due to vasoconstriction and is considering trying Ginkgo Biloba after already taking a multivitamin and hair supplement. Another user mentions experiencing hair shedding with Vyvanse and Dexedrine.
community Can HMI-115 reverse miniaturization?
HMI-115, a potential treatment for hair loss that can reverse miniaturization and make individual hairs thicker, as evidenced by data from macaques given the treatment and one subject in the phase I trial.
community New vellus hairs? 2.5min .5dut
community Concerned about my child’s lack of density. Microneedling help?
A user humorously discusses their 10-month-old's hair loss, suggesting treatments like microneedling, minoxidil, finasteride, and RU58841. Replies include various satirical and exaggerated suggestions, emphasizing the post's satirical nature.
community Pelage have presented only phase 2a. The rest of phase 2 for PP405 will be presented at a later medical meeting
PP405's phase 2a trial results were presented, focusing on safety and pharmacokinetics, with a future meeting planned to share the full dataset. The trial includes a randomized controlled portion and an open-label extension, with no indication of phase 2B completion.
community Vitamin D deficiency hair loss
A 20-year-old male has been experiencing hair loss for three years due to a vitamin D deficiency and has seen no improvement after 3.5 months of taking supplements. Another person suggested that if the hair loss follows a pattern, it might be regular baldness rather than due to the deficiency.
community Why are we using 1.5mm for microneedling? Evidence says we don't need to.
community 28M Experiencing Top Right and Left Side Hair Loss, Minoxidil Concerns, and Shedding in Humid Areas
The user is experiencing hair loss with symptoms of receding hairline, extreme shedding, and low density, possibly due to androgenic alopecia, diffuse thinning, retrograde alopecia, or telogen effluvium. They have used minoxidil and noticed changes in shedding patterns related to different water qualities and seborrheic dermatitis.
community Fragile Regrowth Despite Oral Min and Dut After 1 Year; Diffuse Thinner Concerns
The user is experiencing hair regrowth with oral minoxidil and dutasteride but still has fragile hairs that easily pluck out from the front center. Despite improvements, the user is concerned about the persistent fragility and shedding of these hairs.
community PP405 is NOT gray market jxl069
PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.
community Am I shedding? Cooked? Progress seems to be regressing
The user started taking 1 mg finasteride daily in September 2024 and began derma stamping twice a week, noticing progress initially but now experiencing increased scalp visibility. They are considering adding oral or topical minoxidil to their routine for further improvement.
community Has anyone here actually undergone experimental (grey market) hair cell therapy/follicle cloning?
Hair cell therapy and follicle cloning are still in experimental stages, with treatments like hair multiplication and regenerative hair therapy being marketed but not yet proven to create unlimited new follicles. There is skepticism about the effectiveness and legitimacy of these treatments, with some considering them scams.
community Just sharing my holy grails. I have SO many baby hairs. I suffered with telogen effluvium and personally adding in a protein shake a day helped tremendously, I didn’t realize how packed full of vitamins they were. I used TOPICAL minox and had an elevated heart rate
The user experienced an elevated heart rate from using topical Minoxidil and discontinued its use. They found that adding a daily protein shake helped with telogen effluvium.
community MicroRNA science breakthrough? Softening stem cells
community 3 years of irregular derma rolling and min/Redensyl
The conversation is about someone's three-year experience with irregular derma rolling, Minoxidil, and Redensyl for hair loss, hoping to thicken areas with fine hair.
community 7 Months on Fin + Min + 1 Month Microneedling
The user has been using Finasteride and Minoxidil for 7 months and started microneedling a month ago, but is experiencing increased hair shedding and is concerned about its effectiveness. They have vitamin D3 and B12 deficiencies and are seeking advice and encouragement due to a family history of baldness.
community M[16] Thinning Hair Advice (Desperate)
A 16-year-old is experiencing thinning hair at the front and shedding during showers. He is concerned about potential early baldness and is considering seeing a doctor and taking multivitamins.