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      community RU-58841 without finassteride?

      in Treatment  6 upvotes 1 year ago
      RU58841 is used without finasteride by some due to side effects, with mixed results. Users report combining RU58841 with minoxidil and adjusting finasteride doses to manage hair loss.

      community Anyone here using both Alfatradiol and Fluridil?

      in Treatment  6 upvotes 5 years ago
      User asks if stacking Alfatradiol and Fluridil is effective for hair loss. Alfatradiol is a weaker, topical 5ar inhibitor, while Fluridil is an anti-androgen preventing DHT binding to hair follicles.

      community Are 10% fluridil formulations effective?

      in Treatment  6 upvotes 2 years ago
      The user is asking if using a 10% fluridil formulation would be effective for blocking scalp androgens in addition to their current treatment of oral dutasteride.

      community Anybody used Fluridil ? Is my last hope.

      in Finasteride/Dutasteride  4 upvotes 3 years ago
      The conversation is about alternatives to finasteride for hair loss, with suggestions including fluridil, oral minoxidil, alfatradiol, and cb-03-01. Concerns about finasteride's side effects, including potential breast cancer risk, are also discussed.

      community Finastride is a god send miracle FOR ME

      in Finasteride/Dutasteride  203 upvotes 3 years ago
      . This user experienced positive results from using a combination of minoxidil and finasteride, with no reported side effects after two months. Others have also shared their experiences with both short-term and long-term use of finasteride.

      community Just started my first vial of fluridil

      in Treatment  4 upvotes 2 years ago
      Fluridil was discussed as a hair loss treatment, with some users experiencing side effects like lethargy and chest tightness. Users also mentioned other treatments like RU58841 and finasteride, with mixed opinions on their effectiveness.

      community pyrilutamide solution progress log

      in Product  20 upvotes 3 years ago
      A 28 year old using a hair loss prevention protocol to restore thinning hair, which includes finasteride, dutasteride, minoxidil, stemoxydine, alopecin, nizoral shampoo and microneedling; the user is now adding pyrilutamide solution to the regimen with the hope of improving their results. RU58841 was also ordered but not yet used.

      community Pyrilutamide for non-5AR users?

      in Treatment  10 upvotes 1 year ago
      Pyrilutamide is considered by some as an alternative for those avoiding 5AR inhibitors like finasteride and dutasteride, but opinions on its effectiveness vary. Some users report similar results with fluridil and pyrilutamide, while others find pyrilutamide less effective compared to prescription treatments.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Hydrophobic Finasteride. Why don’t we have it?

      in Chat  6 upvotes 1 year ago
      The conversation discusses the potential benefits of creating a hydrophobic version of finasteride to reduce systemic side effects while maintaining scalp health. It compares this idea to fluridil, which is designed to be hydrophobic and has less systemic absorption.

      community Quitting Alfatradiol after 4 months

      in Product  5 upvotes 1 year ago
      The user stopped using Alfatradiol after 4 months due to no hair improvement and side effects like dry scalp and gallbladder pain. They are considering trying topilutamide, which is suggested as an alternative.

      community Is flying with Fluridil a problem?

      in Treatment  6 upvotes 4 years ago
      The post is about the potential legal trouble of bringing a four-month supply of fluridil, a hair loss treatment, into non-Western countries.

      community Why was fluridil abandoned and never made past phase 2?

      in Chat  4 upvotes 4 years ago
      Fluridil was abandoned due to its weak effectiveness and low binding affinity to the androgen receptor, making it less competitive against DHT and testosterone. Users discuss its limited results compared to other treatments like pyrilutamide and RU58841.

      community Is this hierarchy of topical anti androgens accurate?

      in Ketoconazole  7 upvotes 4 years ago
      User on fin, minox, and ketoconazole seeks to add another topical anti-androgen. Hierarchy of effectiveness: 1. RU55841, 2. Fluridil - Eucapil, 3. CB-03-01 - Breezula, 4. Ketoconazole; alfatradiol suggested as addition.

      community 2 years on fin only :) EOD. No sides.

      in Progress Pictures  191 upvotes 2 years ago
      A user shared their 2-year progress using finasteride every other day with no side effects. Others discussed their experiences, shedding cycles, and patience with the treatment.

      community 11mth daily 0.5mg oral finasteride

      in Finasteride/Dutasteride  835 upvotes 1 year ago
      The user experienced significant hair regrowth with 0.5mg oral finasteride daily, despite a minoxidil allergy, and reported no side effects. They also used a keto shampoo and were satisfied with the results.

      community Actifolic RU58841 and others Scam?

      in Treatment  4 upvotes 3 years ago
      Actifolic's RU58841 and Pyri products are perceived as ineffective, with users reporting no side effects or improvements, suggesting possible quality issues. Users recommend alternative sources and emphasize the importance of timing when using RU58841 with Minoxidil.

      community 11 months oral fin + min capsule

      in Progress Pictures  224 upvotes 1 year ago
      The user has been using a daily capsule containing 1mg finasteride and 2.5mg minoxidil for 11 months, with noticeable regrowth on the crown but minimal improvement on the hairline. They experienced no significant side effects and plan to continue the treatment long-term.

      community Finasteride and fertility

      in General  27 upvotes 1 year ago
      Finasteride's impact on fertility is discussed, with users sharing experiences of conceiving while on the medication. Concerns about long-term safety are also mentioned.

      community Finasteride - discomfort pelvir/urethra

      in Finasteride  79 upvotes 1 year ago
      Finasteride can cause pelvic or urethral discomfort for some users. Reducing the dose to 0.25 mg on Mondays, Wednesdays, and Fridays is being considered as a potential solution.

      community How to effecively mix alfatradiol and finasteride tablets?

      in Treatment  2 upvotes 2 years ago
      The user is using a mixture of crushed finasteride tablets and alfatradiol as a topical treatment for hair loss, applying 1 ml daily, and is asking if this is an effective method or if alfatradiol is a suitable solvent. They mention that others often mix finasteride with minoxidil, but they want to try without it.

      community topical fluridil/eucapil + dut to block all DHT+T from scalp?

      in Treatment  8 upvotes 4 years ago
      User experienced slow gains with topical fin+min, switched to topical dut+min, and considered adding Eucapil. Another user suggested DUT may be less effective topically due to high molar mass and mentioned Fluridil as a weak anti-androgen that could help.