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      community Fin non responders, did Dut ever work? Please share!

      in Finasteride/Dutasteride  17 upvotes 1 year ago
      The conversation discusses the effectiveness of finasteride and dutasteride for hair loss, with some users finding no improvement and experiencing side effects. It also mentions the use of RU58841 and topical minoxidil, highlighting that hair sensitivity to DHT varies among individuals.

      community 3 Months on “Phoenix” 2-in-1 pill (1mg fin + 3mg min oral)

      in Product  1 upvotes 2 months ago
      The user is taking a 2-in-1 pill containing 1mg finasteride and 3mg minoxidil daily, noticing some hair thickening and new hair growth but minimal progress at the back of the head. They are considering adding topical minoxidil or increasing dosage and are unsure if they should change their routine or wait for more results.

      community Dropping RU , not responding..

      in Treatment  6 upvotes 1 year ago
      The user has been using RU58841 for 6 months without noticeable results and is considering dropping it while continuing oral minoxidil, daily dutasteride, and topical minoxidil. Another user suggests visiting a dermatologist to check for other conditions.

      community Pyrilutamide users, any updates?

      in Treatment 3 years ago
      Treatment for hair loss, including Pyrilutamide, Minoxidil, Finasteride, and RU58841; with some users reporting success in growing vellus hairs.

      community PP405 (Non) Update - Feb 2025

      in Research/Science  34 upvotes 1 year ago
      The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

      community Verteporfin (Visudyne) group buy 🌷

      in Treatment  29 upvotes 4 years ago
      User seeks participants for Verteporfin group buy. Verteporfin, FDA approved, may regenerate hair follicles and sweat glands through heavy microneedling.

      community 8 Months on oral min, time to add Fin?

      in General  121 upvotes 10 months ago
      The user has been using 2.5mg oral minoxidil for almost 9 months with reduced shedding but no regrowth and is considering adding oral finasteride despite potential side effects. They plan to consult their dermatologist about this addition to their treatment.

      community Possibilities without Fin/Dut ?

      in Treatment  4 upvotes 1 month ago
      The user experiences severe side effects from finasteride and dutasteride, including low libido and anxiety, and is currently using oral minoxidil despite shortness of breath. They are seeking alternative treatments for hair loss, having tried pyrilutamide, fluridil, and RU58841 with no success, and are considering future treatments or a hair transplant.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Have you noticed systemic absorption of RU58841?

      in Treatment  1 upvotes 5 months ago
      The conversation discusses using RU58841 as a topical treatment for hair loss, with some users reporting no systemic issues. The original poster is considering RU58841 due to limited progress with dutasteride and oral minoxidil.

      community RU-58841 without finassteride?

      in Treatment  6 upvotes 9 months ago
      RU58841 is used without finasteride by some due to side effects, with mixed results. Users report combining RU58841 with minoxidil and adjusting finasteride doses to manage hair loss.

      community Pyrilutamide update number 1 - 1 week use

      in Update  55 upvotes 3 years ago
      A user who is using Pyrilutamide, Finasteride, and a homemade topical solution to treat their hair loss. Replies mentioned the potential of Pyrilutamide being a "cure" for hair loss and a reminder that results may not be credited solely to it.

      community One and a half year on meds (fin/dut, minox)

      in Progress Pictures  54 upvotes 1 year ago
      The user has been using oral minoxidil, finasteride, and dutasteride to prevent hair loss, despite not showing significant balding. Many commenters believe the treatment is excessive, while some support early prevention.

      community If PP405 goes systemic this would be quite catastrophic

      in Research/Science  5 upvotes 1 year ago
      Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

      community Is oral minoxidil f***ing me up?

      in General  269 upvotes 3 months ago
      Oral minoxidil is causing significant blood pressure fluctuations and increased heart rate, leading the user to consider switching to topical minoxidil and tretinoin. The user plans to consult a cardiologist and is likely to stop using oral minoxidil.

      community Found the solution tressbros - 1.5 years 2.5mg oral minox, 5mg finasteride, 8mg estradiol valerate (weekly)

      in Transgender  591 upvotes 2 years ago
      The conversation discusses a transgender individual's successful hair loss treatment over 1.5 years using 2.5mg oral minoxidil, 5mg finasteride, and 8mg weekly injectable estradiol valerate. Some users debate the appropriateness of this approach within the group's goals, while others support the individualized treatment and its additional benefits for transgender individuals.

      community 8 months on oral minoxidil. No sign of regrowth.

      in Minoxidil  14 upvotes 1 year ago
      The user has been taking 2mg oral minoxidil and 1mg finasteride but has seen no hair regrowth after 8 months, leading to concerns about being a non-responder. They are considering increasing the minoxidil dosage or switching to dutasteride, while also using keto shampoo and microneedling, but remain skeptical about the effectiveness of minoxidil.

      community any Ru58841 user ? + What do I need to expect?

      in Product  10 upvotes 1 year ago
      The user is considering adding RU58841 to their current hair loss treatment of finasteride and minoxidil, but is concerned about potential side effects like hairline recession and shedding. Some users report positive results with RU58841, while others experience side effects such as chest pain and dizziness.

      community Can I Put Minoxidil On My Eyelashes?

      in Minoxidil 2 months ago
      Applying minoxidil to eyelashes is unsafe due to potential eye irritation and chemical burns. Safer alternatives include peptide serums, castor oil, or lash lifts/extensions.

      community RU/Pyrilutamide access and purchase

      in Product  3 upvotes 3 months ago
      The conversation is about accessing and purchasing RU58841 or Pyrilutamide for hair loss treatment, with mentions of alternatives like Breezula. Users discuss price differences in various countries and suggest websites like rudirect.com for purchasing.

      community People who upped from 2.5mg to 5mg oral min..

      in Chat  6 upvotes 1 year ago
      Users discussed increasing oral minoxidil from 2.5mg to 5mg for hair regrowth, with some considering higher doses despite potential side effects. They also mentioned using 1mg oral finasteride alongside minoxidil.