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      community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

      in Research/Science  5 upvotes 3 months ago
      Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

      community Best microneedling frequency for supercharged results?

      in Microneedling  3 upvotes 11 months ago
      The conversation discusses hair loss treatments, specifically using a regimen of minoxidil, finasteride, dutasteride, tretinoin, and microneedling. Users debate the optimal microneedling frequency, suggesting 1.5mm once every 1-2 weeks and 0.5mm every other day for better results.

      community About 9 Months on Topical Fin/Min

      in Progress Pictures  585 upvotes 4 years ago
      User shares 9-month progress using topical Fin/Min formula (10% Min, 0.1% Fin) for hair loss, with significant improvement in crown area. Others discuss experiences, side effects, and application methods for the treatment.

      community Improve your micronnedling progress/results using betadine

      in Microneedling  72 upvotes 5 years ago
      A user shared their hair regrowth success using microneedling with a dermaroller every 6 days and minoxidil, recommending betadine (povidone-iodine) before microneedling to sterilize the scalp and enhance results. Another user noted the potential risks of iodine toxicity.

      community Minoxidil, RU58841, CB-03-01, WAY-316606, and derma stamping.

      in Minoxidil  5 upvotes 6 years ago
      The user is using Minoxidil, RU58841, CB-03-01, WAY-316606, Ketoconazole, MK-677, and derma stamping to treat hair loss and has noticed new hair growth, especially around the temples and hairline. They apply different treatments at various times of the day and have seen improvements in skin condition and body hair texture.

      community microneedling efficacy for male pattern baldness?

      in Microneedling  14 upvotes 3 weeks ago
      Microneedling, when combined with finasteride and topical minoxidil, can enhance hair regrowth for male pattern baldness, especially at the temples. Users report varying success with needle depths between 0.5mm and 1.5mm, with stamps preferred over rollers to minimize scalp damage.

      community What kind of tretinoin should i get?

      in Progress Pictures  1 upvotes 5 months ago
      OP is seeking advice on which percentage of tretinoin to use to enhance the effectiveness of minoxidil for hair loss. They are unsure about choosing between 0.1%, 0.025%, or 0.05% tretinoin.

      community Y'all, we have got to come to a consensus on the specifics of microneedling.

      in Microneedling  27 upvotes 3 years ago
      Microneedling can promote hair growth, but there is uncertainty about the best practices, including needle length, device, and session frequency. Users discuss using needle lengths between 0.5mm and 1.5mm, with some experiencing pinpoint bleeding, and emphasize the need for more reliable resources and guidelines.

      community Am I misunderstanding the medication dosage calculation?

      in Product  2 upvotes 11 months ago
      The conversation discusses confusion over the dosage calculation of a topical solution containing 0.25% finasteride, 5% minoxidil, and 0.001% tretinoin. The user considers switching to a 0.025% finasteride solution to enhance the effects of tretinoin and minoxidil.

      community Has anyone tried combining Minoxidil with AlphaInfuse?

      in Is this regrowth?  2 upvotes 8 months ago
      The conversation discusses the use of AlphaInfuse, a micro-infusion system with Panax ginseng and Eclipta prostrata extracts, for hair growth and its comparison to Minoxidil. The original poster seeks personal experiences and evidence of its effectiveness.

      community Compounding for topical formulations?

      in Treatment  1 upvotes 2 years ago
      The post discusses the high cost of a topical hair loss treatment from Happy Head, which contains finasteride, minoxidil, retinoic acid, and hydrocortisone. The user is seeking cheaper alternatives, specifically asking if there are compounding pharmacies that can recreate the same or similar formulation.

      community Minoxidil hack PSA for you all

      in Treatment  59 upvotes 1 year ago
      Switching from liquid to foam Minoxidil to avoid scalp irritation, with a method to melt the foam for easier application. Users discuss alternatives and personal experiences with Minoxidil, including issues with propylene glycol and different application methods.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Caffeine + Dimethylglycine (DMG) Shampoo research

      in Research/Science  6 upvotes 1 year ago
      A user discusses the potential of caffeine and DMG in shampoo for treating hair loss, citing a pending patent and personal plans to test it. They find it more convenient than using minoxidil, tretinoin, and microneedling.

      community 2.5MG Oral Minoxidil, Is This Regrowth?

      in Is this regrowth?  4 upvotes 10 months ago
      The user is using 2.5mg oral Minoxidil, rosemary mint oil, scalp massaging, a derma roller, multivitamins, and hair vitamins for hair regrowth. They are considering adding pumpkin seed oil, a derma pen, and saw palmetto vitamins, and are advised to consider finasteride.

      community hair and miniaturization after 6 months of treatment

      in Female  3 upvotes 1 year ago
      A female user is experiencing minimal regrowth and miniaturized hair after 6 months of treatment with oral minoxidil, spironolactone, and topical minoxidil. She seeks advice on whether she can restore her remaining follicles.

      community 1.5 years on topical fin + min

      in Progress Pictures  234 upvotes 11 months ago
      The user has been using 0.25% topical finasteride and 5% minoxidil for 1.5 years with significant hair improvement and plans to start microneedling and possibly switch to oral finasteride for better long-term results. They are happy with the progress but seek more hair density and have not experienced any side effects.

      community Finally got hold of 0.1% latanoprost

      in Treatment  6 upvotes 2 months ago
      The conversation is about a user obtaining a compounded treatment for hair loss, including 0.1% latanoprost, 0.2% melatonin, and 1% cetirizine. The user also uses 2.5 mg dutasteride, 5 mg minoxidil, and RU58841 daily, and is at Norwood 2.

      community Pelage PP405 Phase 2a completed.

      in Research/Science  60 upvotes 3 months ago
      Minoxidil, finasteride, and RU58841 are discussed as treatments for hair loss, with excitement around a new drug, PP405, and a reformulated oral minoxidil in trials. Concerns about cost, side effects, and long-term use are also mentioned.

      community Wow, a big thank you to min and fin and this sub

      in Update  126 upvotes 9 months ago
      The user experienced visible hair improvement after using oral minoxidil (5 mg daily) and finasteride (1 mg daily) for less than a year, with no noticeable side effects. They encourage others to try these treatments if they notice signs of hair loss.

      community If the main mechanism of microneedling is an increase in bloodflow to the scalp, shouldn't we be pursuing other actions which increase bloodflow? Sauna, cold showers, high dosage fish oil, hard cardio, heme-iron(red meats), HAND STANDS, foods high in NO (arugula), ginger, increased water consumption

      in Question  18 upvotes 6 years ago
      Microneedling stimulates hair growth through stem cell activation during wound healing, not just increased blood flow. Other methods like showers or supplements don't replicate this effect.

      community M25 - Topical Fin 0.3% Min 6%.

      in Progress Pictures  23 upvotes 8 months ago
      A 25-year-old is using a nightly routine of topical finasteride 0.3% and minoxidil 6%, along with a derma roller and Nizoral shampoo, to address crown hair loss. The user reports no side effects and noticeable improvement over 2.5 months.