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      community Dermal incision with verteporfin

      in Research/Science  4 upvotes 6 months ago
      Dermal incision with verteporfin is being explored as a potential hair loss treatment by dermatologist Melissa Toyos, with promising before-and-after photos shared on social media. The conversation discusses its potential effectiveness compared to other treatments like Minoxidil, Finasteride, and RU58841.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Starting Pyrilutamide BID. First dose was yesterday. Diffuse thinning. I will put my full regimen below.

      in Research/Science  89 upvotes 3 years ago
      A user's regimen to help with their diffuse thinning, which includes taking Pyrilutamide BID, 1mg finasteride daily, 2.5mg oral minoxidil daily, topical minoxidil since August 2021, LLLT every two days, topical fin, progesterone, melatonin, minoxidil (started one week ago), pumpkin seed oil and not dermarolling; other commenters suggested Nizoral for dandruff control and caution when using pre-mixed products with Pyrilutamide.

      community I’m taking Veradermics VDPHL01 - AMA

      in Treatment  174 upvotes 1 month ago
      A participant using Veradermics VDPHL01, an extended-release oral minoxidil, experienced significant hair regrowth from Norwood 6 to Norwood 3V without side effects. They plan to use dutasteride after the treatment to maintain results.

      community EU topical melatonin recommendations?

      in Treatment  6 upvotes 5 months ago
      The conversation discusses recommendations for using topical melatonin for hair loss treatment. It also mentions Minoxidil, finasteride, and RU58841 as other treatments.

      community Just a rule of thumb regarding "the cure™"

      in Chat  8 upvotes 4 months ago
      Be skeptical of claims about new baldness cures; current treatments like finasteride, dutasteride, and minoxidil remain the best options. New products like Breezula and PP405 lack compelling evidence and may not be available soon.

      community Does pyri/kx826 degrade in exposure to bathroom light?

      in Treatment  5 upvotes 1 year ago
      The conversation discusses concerns about RU58841 degrading when exposed to light and transferring pyri to a dark glass bottle to prevent this. The user keeps the pyri out for only two minutes before storing it in a dark place.

      community Pyrilutamide or RU or cb-03-01?

      in Minoxidil  2 upvotes 6 months ago
      The conversation discusses using Minoxidil, finasteride, RU58841, and pyrilutamide for hair loss treatment. The user is considering adding a topical treatment and has not experienced side effects from current treatments.

      community Verteporfin Update with Dr Blake Bloxham

      in Research/Science  27 upvotes 2 years ago
      The conversation discusses Dr. Blake Bloxham's experiment with Verteporfin for hair loss, with one person suggesting more doctors should try it as it seems beneficial. Another comment notes that results at 4-5 months were not very impressive.

      community Hair regrowth without drugs (99% natural) 25M

      in Progress Pictures  423 upvotes 4 weeks ago
      A user shared their experience with hair regrowth using supplements like NAC and DIM, and briefly using minoxidil with microneedling. They reported some improvement in hair density, but the community questioned the effectiveness compared to traditional treatments like finasteride.

      community Occipitalis Muscle Tension Theory

      in Treatment  10 upvotes 4 months ago
      Scalp tension from the occipitalis muscle is theorized to contribute to hair loss, but most believe DHT and genetics are the main causes. Treatments like finasteride and minoxidil are considered more effective than addressing scalp tension.

      community My Theory Of Androgenic Alopecia

      in Research/Science  20 upvotes 6 months ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

      community Creatine is the opposite of minoxidil !

      in Research/Science  315 upvotes 8 months ago
      Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

      community PP405 timeframe ? Could it replace current treatments ?

      in Update  34 upvotes 11 months ago
      PP405 is a potential new hair loss treatment that might replace finasteride and minoxidil, but it is still in clinical trials and may not be available until 2028-2031. There is skepticism about its effectiveness, with only a 20% increase in hair density observed in some participants.

      community Dut is duting ig. 1 year progress.

      in Progress Pictures  430 upvotes 1 year ago
      The user has been using 5% minoxidil, finasteride, and dutasteride, along with microneedling and ketoconazole, to treat hair loss, showing significant progress over a year. Side effects mentioned include brain fog, watery semen, and facial dryness.

      community Unpopular Opinion: hair cloning kind of sucks as a potential future cure.

      in Technology  27 upvotes 1 year ago
      Hair cloning is seen as a distant and potentially less relevant solution for hair loss due to its high cost, invasiveness, and the advancement of other treatments like Minoxidil and finasteride. Many believe that by the time hair cloning becomes viable, other less invasive and more effective treatments will be available.

      community Being Bald vs Balding - My experience after shaving it off

      in Update  217 upvotes 1 year ago
      A man in his thirties found increased confidence after shaving his head, despite years of hair loss. Others discussed using treatments like finasteride, minoxidil, and hair transplants, with mixed opinions on their effectiveness.

      community Horrible news, Stemson Therapeutics has shut down

      in Technology  192 upvotes 1 year ago
      Stemson Therapeutics has shut down, disappointing those seeking a hair loss cure. Current treatments like minoxidil, finasteride, and dutasteride are discussed, with some users experiencing side effects and exploring alternatives like PP405.

      community I shaved my head. Trust the progress guys

      in Shaved/buzzed  460 upvotes 1 year ago
      The user shaved their head and is using finasteride and minoxidil for hair loss, expressing confidence in the process despite challenges. They are considering additional treatments like microneedling and are open to trying different looks, including facial hair growth.