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      community Anyone here has experience with ‘nuke’ protocols?

      in Research/Science  4 upvotes 5 years ago
      The conversation discusses aggressive hair loss treatments, including finasteride, dutasteride, minoxidil, topical cetirizine, and experimental options like Estrogel, oh-flutamide, and RU58841. Users share experiences and suggest trying oral minoxidil and el cranell, noting the complexity and challenges of treating hair loss.

      community My current stack/personal program

      in Update  1 upvotes 1 year ago
      The user is using RU58841, Revivogen, Regenepure ketoconazole shampoo, and plans to use a stimufield cap to address hair loss. They aim to avoid finasteride and minoxidil while hoping to stop hair loss and regrow hair.

      community Stemoxydin and hair cycle question

      in Treatment  2 upvotes 2 years ago
      The user has been using Finasteride for hair loss and is considering adding alphatradiol, stemoxydine, or 2% minoxidil to their regimen. They are concerned that stemoxydine, which shortens the resting phase of hair, might accelerate hair loss in those not using Finasteride by depleting hair cycles without strengthening miniaturized hairs.

      community Microneedling makes a difference. Non responders, please read

      in Microneedling  66 upvotes 2 years ago
      A 48-year-old who had been thinning since 25 and reached NW4-5 baldness saw no improvement with 1mg/day finasteride and 5% minoxidil twice a day after 8 months. After copying another person's routine, they now use 0.5mg finasteride, ketoconazole shampoo weekly, daily microneedling with 0.5mm and 1mm once a week, and apply minoxidil twice daily, resulting in baby hairs on their bald spot and temples after three months.

      community cb-03-01 research chem (winlevi/clascoterone cream)

      in Technology  3 upvotes 2 years ago
      The user is considering using CB or clascoterone for hair loss, potentially as an alternative to RU. They're also contemplating asking a dermatologist for topical clascoterone cream to apply to their temple.

      community Alternatives/unorthodox hairloss protocols to the big three

      in Chat  1 upvotes 3 months ago
      The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

      community Does girlfriend ASMR overpower finasteride?

      in Satire  227 upvotes 1 year ago
      A humorous discussion on hair loss, suggesting girlfriend ASMR might counteract finasteride's effects, with a proposed experiment involving finasteride, ASMR, and control groups. Participants joke about evolutionary theories, ASMR, and the effects of DHT on balding.

      community Summary of future treatments from 2020

      in Chat  53 upvotes 10 months ago
      Hair loss treatments include finasteride, minoxidil, microneedling, dutasteride, CB-03-01, RU-58841, and experimental options like KY-19382 and stem cell therapy. Some treatments are considered ineffective or risky, such as ketoconazole, PRP, and low-level laser therapy.

      community Regrowth with only Nizoral and Lifestyle Changes; focusing on scalp health & nervous system

      in Is this regrowth?  88 upvotes 3 months ago
      The user reported subtle hair regrowth by focusing on scalp health and lifestyle changes, using Nizoral shampoo and methods to reduce inflammation and cortisol, without using finasteride, minoxidil, or other common treatments. Opinions in the conversation varied, with some skeptical of the results and others acknowledging the potential benefits of addressing scalp health and inflammation.

      community What's the deal with Spectral.DNC-N/'nanoxidil'?

      in Minoxidil  5 upvotes 3 years ago
      Nanoxidil is considered to have better absorption and fewer side effects than minoxidil, with added DHT blockers. The user is questioning if switching to the more expensive Spectral.DNC-N is worthwhile compared to cheaper options like Kirkland minoxidil.

      community Glad I took treatment. (Dut, fin,min, microneedling)

      in Progress Pictures  12 upvotes 9 months ago
      The user is using a hair loss treatment involving dutasteride, minoxidil, finasteride, microneedling, and supplements like multivitamins, D3 K2, and Omega 3 fish oil. They are considering adding tretinoin and are open to suggestions while managing gut issues.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 2 years ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.

      community Medication works - First Pic June 2020

      in Progress Pictures  695 upvotes 2 years ago
      The user improved their hair loss using finasteride, switched to dutasteride, micro-needling, Nizoral shampoo, and changed from topical to oral minoxidil, resulting in thicker hair, eyebrows, beard, and body hair. Commenters are impressed with the transformation, some mistaking the before and after photos for different people, and the user reports no side effects from the treatments.
      The story of RU58841/ PSK3841

      community The story of RU58841/ PSK3841

      in Research  622 upvotes 1 year ago
      RU58841, a potential hair loss treatment, was not commercialized due to marketability issues and lack of long-term safety data. Concerns about its formulation and delivery methods further complicate its use.

      community PP405 mechanism question - looking for discussion

      in Treatment  6 upvotes 1 month ago
      PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

      community Kintor Pharma Announces Positive Top-line U.S. Phase I Trial Results of GT20029, the World’s First Topical Use PROTAC Compound

      in Research/Science  127 upvotes 3 years ago
      The conversation discusses positive initial trial results for GT20029, a topical compound for hair loss that degrades androgen receptors, potentially requiring only weekly application. Participants express hope for this treatment to be more effective and convenient than current options like Minoxidil, Finasteride, and RU58841.

      community Verteporfin day 119 update - donor hair regeneration human trial

      in Research/Science  145 upvotes 3 years ago
      A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

      community Got complimented on my hair today

      in Styling  43 upvotes 1 year ago
      The user experienced significant hair regrowth using a treatment of finasteride, minoxidil, tretinoin, and microneedling, reducing their Norwood scale from 2.5 to 1.5 in six months. They received compliments on their hair, boosting their confidence, and are now reducing their finasteride intake due to quick progress and potential side effects.

      community Am I responding Or Am I tripping?

      in Progress Pictures  17 upvotes 11 months ago
      The user is using Minoxidil, Finasteride, Nizoral, Nutrafol supplements, and PRP sessions for hair loss treatment. They are concerned about the effectiveness of these treatments and whether they should continue or consider a hair transplant.

      community Before and after pics with Microneedling + possible confounds

      in Progress Pictures  4 upvotes 5 years ago
      The user experienced hairline improvement using microneedling once a month with a 12-pin set at 1.5-2.0mm and taking Tru Niagen, alongside a heavily modified diet. They attribute the slow hairline improvement to environmental factors, particularly diet, rather than solely genetic factors.

      community Treatment from July 2025 - Present

      in Is this regrowth?  17 upvotes 6 months ago
      The user is experiencing hair regrowth using 1mg oral finasteride daily, Minoxidil foam twice a day, and microneedling weekly with a 1.5mm needle. They are seeking feedback and suggestions to optimize their hair regrowth.