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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community My Experience and a Discourse on "DUPA"

      in Treatment  8 upvotes 1 year ago
      The user discusses their hair loss experience, exploring various hypotheses including thyroid levels, vitamin D, DHEA, nutritional deficiency, diabetes, seborrheic dermatitis, lack of nutrition to hair follicles, chronic inflammation, female pattern hair loss causes, cortisol, and prolactin levels. They are currently using finasteride, beta-sitosterol, and have tried topical dutasteride and microneedling therapy.

      community My Dutasteride and oral min results

      in Progress Pictures  59 upvotes 6 months ago
      The user shared progress pictures showing improved hair health and growth after 10-12 months of using oral dutasteride, oral minoxidil, and topical minoxidil with finasteride. They experienced shedding initially but noticed significant progress recently.

      community Taking Topical Minoxidil Orally Week 14

      in Satire 4 years ago
      Taking Minoxidil topically for hair loss and the results, which included jokes about castration, Daenerys Targaryenism, and a hair system. People in the conversation also shared positive affirmations and humorous comments.

      community Dutasteride UPDATE (female) *sixth month*

      in Progress Pictures  17 upvotes 3 years ago
      A female user in her mid-20s with androgenetic alopecia and suspected telogene effluvium who has been taking Dutasteride, Spironolactone, Minoxidil, Dermarolling, Ketoconazol shampoo, and Yaz contraception for her hair loss for the past 6 months. She had a small shed during this time that she believes to be stress related.

      community Dutasteride mesotherapy alongside oral fin and dut?

      in Research/Science  2 upvotes 3 months ago
      Dutasteride mesotherapy, combined with peptides and exosomes, is being considered for hair loss treatment. One user suggests that oral finasteride or dutasteride mesotherapy may not be necessary if already taking oral dutasteride.

      community Before and after pics with Microneedling + possible confounds

      in Progress Pictures  6 upvotes 5 years ago
      The user experienced hairline improvement using microneedling once a month with a 12-pin set at 1.5-2.0mm and taking Tru Niagen, alongside a heavily modified diet. They attribute the slow hairline improvement to environmental factors, particularly diet, rather than solely genetic factors.

      community Good hair days; finastride

      in Finasteride/Dutasteride  15 upvotes 4 years ago
      The user expresses positivity about managing hair loss and celebrates good hair days. They mention using finasteride (Propecia) as part of their treatment.

      community Are fruit seeds more effective than fin/Dut?

      in Finasteride/Dutasteride 2 months ago
      The user experienced reduced hair loss after switching from finasteride and dutasteride to consuming fruit seeds like pumpkin and flaxseed, but others suggest the improvement is likely due to the delayed effects of the medications. There is skepticism about the seeds' effectiveness in blocking DHT compared to the medications.

      community progress from april 2024 to june 2025

      in Progress Pictures  170 upvotes 9 months ago
      The conversation is about a user's impressive hair recovery over 14 months using 0.5mg dutasteride, 5% topical minoxidil, saw palmetto shampoo, and occasional microneedling. The results are highly praised by others, with many expressing admiration and hope for similar outcomes.

      community Thoughts? 9 months of treatment

      in Progress Pictures  16 upvotes 1 year ago
      A user shared progress pictures after 9 months of using 1 mg finasteride, 2.5 mg oral minoxidil, microneedling, and ketoconazole, noting no visible improvement and considering switching fully to dutasteride. Another user commented that there were gains in the temples and praised the early intervention.

      community Even male lions can’t escape balding

      in Satire  185 upvotes 6 months ago
      Hair loss treatments discussed include dutasteride and oral minoxidil. The conversation humorously compares male lions' manes to human balding.

      community Help! Gyne after 20 years of taking Dut

      in Finasteride/Dutasteride  39 upvotes 1 year ago
      A 43-year-old experienced gynecomastia after 20 years of taking dutasteride and 7.5mg oral minoxidil. Suggestions include consulting an endocrinologist, checking hormones, and considering Nolvadex or DIM supplements.

      community Odd fear of not getting meds in a coma or similar

      in Chat  20 upvotes 1 week ago
      Concerns about hair loss treatments like finasteride and minoxidil not being administered during a coma. Dutasteride remains in the system longer, and hair loss may not be immediate if treatment stops temporarily.

      community my gains after 7 months (nuclear stack)

      in Progress Pictures  1914 upvotes 1 year ago
      The user shared impressive hair growth results after 7 months using a regimen of dutasteride, topical minoxidil, and biotin, alongside a healthy lifestyle. The conversation humorously discusses extreme and unconventional hair loss treatments, with many users expressing amazement and curiosity about the progress.

      community My experience switching to Dut

      in Progress Pictures  95 upvotes 8 months ago
      The conversation discusses hair loss treatments, specifically the transition from finasteride and minoxidil to dutasteride, with positive results reported by the original poster. Users share experiences with these treatments, noting varying effectiveness and side effects.

      community DHT blocking ingredients

      in Treatment  6 upvotes 5 years ago
      The conversation discusses DHT blocking treatments for hair loss, specifically mentioning Minoxidil, Finasteride, and organic flaxseed oil containing omega-3 fatty acids. It highlights skepticism about alternative treatments and emphasizes the proven effectiveness of Finasteride and Dutasteride.

      community Wednesday after micro needling through Friday today.

      in Treatment  1 upvotes 1 year ago
      The user is using oral and topical minoxidil, finasteride, dutasteride, and considering adding rosemary and pumpkin saw palmetto to their regimen. They report significant hair growth, especially with dutasteride, and are considering increasing their dose and adding RU58841.

      community Pyrilutamide for 16 weeks, with some progress

      in Progress Pictures  40 upvotes 2 years ago
      User gained hair with topical minoxidil and finasteride, then experienced shedding after starting pyrilutamide. After 12 weeks, new hairs grew and existing hairs thickened, hoping for more improvement in a year.

      community Microneedling sometimes feels like

      in Satire  19 upvotes 7 months ago
      Microneedling for hair loss is discussed, with users mentioning using 0.6mm needles twice a week. Treatments like Minoxidil, finasteride, and RU58841 are implied but not directly mentioned.

      community HydraPen to inject topical fin and min

      in Product  4 upvotes 2 years ago
      The conversation discusses using a Hydra Pen to inject topical finasteride and Minoxidil for hair loss treatment. A user reports no side effects after one week of use and plans to share results in two months.

      community Pyrilutamide - cosmetic vs. clinical trials

      in Treatment  3 upvotes 3 months ago
      The conversation discusses the difference between the commercially available Pyrilutamide and the version in clinical trials. It also mentions treatments like Minoxidil, finasteride, and RU58841 for hair loss.

      community 6 Month Update on Dut and Minox

      in Progress Pictures  331 upvotes 1 year ago
      A 27-year-old male reported significant hair improvement after 6 months on 0.5 mg Dutasteride daily and 2.5 mg Minoxidil daily, with Nizoral shampoo twice a week. He experienced increased body/facial hair but no other side effects, and his hair density and hairline improved.