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      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  39 upvotes 3 years ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community What ever happened to pyrilutamide?

      in Technology  48 upvotes 3 years ago
      Pyrilutamide, a potentially effective hair loss treatment; other topical treatments like RU58841 and CB-03-01 that may have fewer side effects than Pyrilutamide; and the Phase 3 clinical trials of Pyrilutamide, which is likely to be approved by the FDA soon.

      community Dermaneedling+minox+tretinoin+azaleic acid and hair loss

      in Minoxidil  1 upvotes 5 months ago
      The user stopped oral treatments due to side effects and switched to a regimen of topical minoxidil, tretinoin, azelaic acid, and dermaneedling, with recent addition of topical finasteride. They are questioning the long-term effectiveness of non-hormonal methods and considering hair transplantation.

      community Hairline stable but diffuse thinning with topical fin+min

      in Finasteride  237 upvotes 4 months ago
      The user experienced stable hairline but diffuse thinning after switching from oral finasteride to a topical solution of minoxidil and finasteride. They are concerned about the effectiveness of the topical treatment and are considering other options due to a recent decline in hair density.

      community Pyrilutamide 4 Month Journey with progress Pics..!!!

      in Progress Pictures  21 upvotes 10 months ago
      The user reported significant hair regrowth and stopped hair loss after using Pyrilutamide and Minoxidil for four months. They found Pyrilutamide effective in blocking DHT locally without side effects, preferring a gray market version over Koshine's product.

      community Do we have anything in the pipeline that is used as a replacement for minoxidil?

      in Minoxidil  17 upvotes 1 year ago
      The conversation discusses hair loss treatments, focusing on alternatives to Minoxidil, such as Bimatoprost and Latanoprost, and the use of Finasteride, Dutasteride, RU58841, and microneedling. The user plans to add Latanoprost to their regimen, which already includes oral and topical Minoxidil and Finasteride, Ketoconazole shampoo, and microneedling.

      community Anyone having little results with dutasteride and oral minoxidil

      in Treatment  7 upvotes 5 months ago
      Dutasteride and oral minoxidil are not yielding noticeable results for some users, with some considering alternatives like microneedling or hair transplants. Others report slowed hair loss but no regrowth, and some experience side effects or minimal improvement, leading to frustration and consideration of different treatments.

      community What is your stack and what is your protocol for it?

      in Chat  18 upvotes 2 years ago
      A user maintains NW2 hair with 1mg finasteride, 2.5mg oral minoxidil, and 5% topical minoxidil twice daily, along with ketoconazole shampoo and derma stamping. They seek advice on more aggressive treatments to achieve NW1.

      community Minoxidil+ Spray by keep does it contain propylene glycol?

      in Minoxidil  1 upvotes 1 year ago
      The user is using Dutasteride and oral Minoxidil for hair regrowth and is considering adding topical Minoxidil but is allergic to propylene glycol, which is present in the product they found. They need a solution with tretinoin that does not contain propylene glycol.

      community Kintor develop GT20026 Anti-Androgen receptor drug with NO SIDES

      in Treatment  18 upvotes 5 years ago
      The conversation discusses GT20029, a new topical drug for hair loss and acne without notable side effects, which has been accepted for investigational use in China. Some users express skepticism about the legitimacy of the company and the potential for other drugs like RU58841 to be developed due to patent expiration and lack of profitability.

      community any minox non-responders turn to good responders after adding microneedling or tretinoin?

      in Minoxidil  7 upvotes 3 years ago
      The conversation is about someone who initially had positive results with Minoxidil for hair loss, lost those gains due to a hospital stay, and is now not seeing the same results upon resuming treatment. They plan to add microneedling and/or tretinoin to their regimen and are seeking success stories from others who did not respond to Minoxidil alone.

      community Once daily topical Min, weekly 1.5 mm dermarolling

      in Progress Pictures  35 upvotes 2 years ago
      The user has been using 5% minoxidil once daily and microneedling with a 1.5 mm dermaroller weekly for three months, considering increasing minoxidil usage but avoiding finasteride due to libido concerns. Another person suggests considering other treatments like RU58841, alfatradiol, topical finasteride, clascoterone, or saw palmetto since not using a DHT blocker could be less effective.

      community Is it safe to use topical 5% Min and 3mg Min together?

      in Minoxidil  2 upvotes 1 year ago
      A 36-year-old man is using topical 5% Minoxidil for hair thinning and is considering adding 3mg Minoxidil pills as recommended by a dermatologist. He is concerned about potential side effects and increased shedding but cannot access Finasteride due to strict regulations.

      community What’s the update on Pyrilutamide?

      in Chat  12 upvotes 3 years ago
      Pyrilutamide is seen as a last hope for those who can't take finasteride, with promising results reported. However, there's uncertainty about the quality and consistency of Pyrilutamide from black market sources.

      community Oral min 2.5mg closing in on 3 months

      in Progress Pictures  372 upvotes 3 years ago
      _the_orange_box_'s experience using oral minoxidil, with discussion about finasteride and the potential side effects of both treatments. Other users shared their own experiences related to hair loss treatments.

      community Life after minoxidil? Has anyone stopped

      in Update  147 upvotes 2 years ago
      A user stopped using minoxidil after 10-12 years due to severe side effects like fluctuating blood pressure and chest pain, resulting in significant hair loss. Other users shared similar experiences, emphasizing health over hair and suggesting alternatives like finasteride, nanoxidil, and rosemary oil.

      community the ordinary retinol & minoxidil

      in Minoxidil  13 upvotes 1 year ago
      Using retinol with minoxidil may not be as effective as tretinoin, but retinaldehyde or adapalene could be alternatives. A micro-roller with minoxidil is suggested for better results.

      community How long should I wait to see if 5 mg oral min works for me? Titrated a couple weeks ago from 2.5 mg. Started at 1.25 mg about 300 days ago

      in Minoxidil  38 upvotes 1 year ago
      A 33-year-old user has been on finasteride for 10 years with great results and recently increased their oral minoxidil dose to 5 mg to improve hair thickness and possibly regrow hair. They are considering microneedling and a hair transplant to enhance their hairline and temples, despite already having significant improvement.

      community Clascoterone 5% solution infographic

      in Update  132 upvotes 6 months ago
      Clascoterone 5% solution is discussed as a potential new treatment for hair loss, offering an alternative for those who can't use finasteride or need additional options beyond minoxidil. Concerns about cost, effectiveness, and safety compared to existing treatments like RU58841 and finasteride are highlighted.

      community 12 month mark on cheap Mexican finasteride (Novaride). It works!

      in Update  219 upvotes 1 year ago
      User reports 12 months of using Mexican finasteride (Novaride), minoxidil spray, and ketoconazole shampoo with significant crown improvement and slight frontal hairline improvement. No current side effects; plans to continue treatment for further gains.

      community RU58841 in Canada, which vehicle is better?

      in Product  5 upvotes 4 years ago
      A user is seeking advice on purchasing RU58841 with Minoxidil in Canada and is concerned about the vehicle used for the solution. They also inquire about the differences between RU58841 and topical finasteride in terms of efficacy.

      community Recommend stemoxydine as an adjunct therapy

      in Treatment  4 upvotes 2 years ago
      The user has been using finasteride, minoxidil, retinoid, and occasional microneedling for hair loss with good results. They recently added stemoxydine, which improved their hair further, and suggest trying it, especially in the EU where it's easily available.