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GlossaryEstrogenic Activity

ability of a substance to mimic or influence estrogen effects

Estrogenic activity refers to the ability of a substance to mimic or influence the effects of estrogen, a primary female sex hormone, in the body. This can impact various biological processes, including reproductive health, bone density, and hair growth. Substances with estrogenic activity can bind to estrogen receptors and trigger similar responses as natural estrogen, which is why they are significant in both medical treatments and environmental health studies.

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community Aromatase Upregulation along with DHT down regulation could possibly hold the cure

in Microneedling 7 upvotes 4 years ago

The post discusses the potential of upregulating aromatase to treat hair loss, suggesting that increasing CCL2 levels through Vitamin D or microneedling might help. The user questions why microneedling doesn't work for everyone, especially those with advanced hair loss.

community Should I just keep trusting my medicine?

in Treatment 6 upvotes 4 years ago

A user noticed hair thinning and was prescribed spironolactone, which led to increased hair loss. They were advised to switch to finasteride.

community Switch from fin to dut and its worse

in Finasteride/Dutasteride 4 upvotes 1 year ago

Switching from finasteride to dutasteride can worsen hair loss for some men due to increased testosterone levels. Topical treatments like RU58841 and Pyrilutamide are suggested to counteract these effects, but individual responses vary.

community The most nuclear stack possible

in Satire 43 upvotes 1 year ago

A user humorously suggests an extreme hair loss treatment regimen involving multiple medications and therapies, including Dutasteride, Minoxidil, RU58841, and others, claiming it would prevent hair loss but with potential side effects like gynecomastia. The conversation highlights concerns about safety, side effects, and the effectiveness of such a comprehensive approach.

community How do you keep your bloodsugar low on finasteride?

in Finasteride/Dutasteride 12 upvotes 2 years ago

Finasteride may affect blood sugar and metabolism, with some users reporting increased blood sugar and changes in body composition. To manage potential side effects, users suggest exercise, intermittent fasting, and dietary adjustments.

community 4 months on 2.5 mg OM, no improvement

in Minoxidil 6 upvotes 3 years ago

After 4 months on oral minoxidil with no significant hair regrowth, a user is frustrated and considering alternative treatments since they can't take finasteride due to side effects. Suggestions include natural DHT blockers, lifestyle changes, and other hair care tips.

community Topical spironolactone - anti androgen

in Research/Science 8 upvotes 3 years ago

User asks about topical spironolactone experience. Two studies show it as promising anti-androgen treatment, with 5% cream available on Minoxidilmax website.

community 5 Months on topical Fin/Min progress: grows hair and boobs

in Progress Pictures 159 upvotes 8 months ago

The user experienced significant hair growth using topical finasteride and minoxidil but noticed nipple changes, suggesting early gynecomastia. They plan to stop the treatment and consider blood work to check hormonal balance.

community The Ultimate Guide to growing your hair back (revised).

in Treatment 161 upvotes 1 year ago

Hair loss treatments include using finasteride, dutasteride, and RU58841. Lifestyle changes like increasing carb intake and moderate alcohol consumption are suggested to boost estrogen levels.

community Reversing Hairloss with 7α-Methyl-19-Nortestosteron aka Trestolone

in Treatment 9 upvotes 1 year ago

The user experienced significant hair regrowth using Trestolone, GHK-Cu, and Minoxidil. They avoided Finasteride due to concerns about side effects and noted that their approach reduced androgenic load, contributing to hair regrowth.

community DHT Isn't (Directly) Important

in Research/Science 103 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community Impressed by the progress but think it’s time to go for the transplant?

in Progress Pictures 288 upvotes 2 years ago

The user started taking 2.5mg minoxidil tablets daily and reduced their finasteride dose to 0.5mg due to side effects. They are considering a hair transplant but are unsure if they should proceed now or wait after seeing the effects of the reduced finasteride dosage.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 126 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community My Testosterone results before and after Finasteride

in Update 147 upvotes 4 years ago

Finasteride significantly increased testosterone levels for the user, with no major side effects except watery semen, which was resolved with zinc supplements. The user's hairline stopped receding and slightly improved.

community Injecting stomach fat into the scalp could cure baldness in just six months

in Update 114 upvotes 7 years ago

A potential treatment for hair loss that involves injecting fat into the scalp; the role of testosterone and estrogen in thinning fat tissue under the skin; research on using lard to treat androgenic alopecia, as well as PRP + ACELL/amniotic stem cell treatments; and ongoing clinical trials by doctors involved in the study.

community Yes your lifestyle and diet has its role in hair loss.

in Chat 296 upvotes 10 months ago

Diet and lifestyle changes can reduce hair shedding but won't regrow hair lost to genetic male pattern baldness. Treatments like finasteride and dutasteride are necessary for significant hair regrowth.

community Why are people so negative regarding Clascoterone (Breezula)?

in Treatment 18 upvotes 1 month ago

Clascoterone (Breezula) shows promising hair growth results, but skepticism remains due to past disappointments with new treatments. It may be a good alternative for those who can't tolerate finasteride or dutasteride, and can potentially be combined with them and minoxidil for better results.

community Finasteride and Eye Problems: You’re Not Going Crazy

in Finasteride/Dutasteride 503 upvotes 1 year ago

Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.

community How true is the statement: dead follicles don't grow back?

in Research/Science 111 upvotes 1 year ago

Hair follicles usually go dormant rather than die, and treatments like finasteride, minoxidil, and hormone therapy can sometimes reactivate them, though results vary. Complete regrowth is rare, especially in long-term bald areas, but some individuals see significant improvement with these treatments.

community Would Fluridil and Alfatradiol work effectively in conjunction with each other?

in Treatment 6 upvotes 6 years ago

Whether using both Fluridil and Alfatradiol together could be more effective than either one alone as a hair loss treatment, given their different mechanisms of action.

community I’m considering stopping finasteride

in Finasteride/Dutasteride 157 upvotes 6 months ago

The user is considering stopping finasteride due to depression, anxiety, and difficulty building muscle, despite its effectiveness in stopping hair loss. Suggestions include reducing the dose, switching to topical solutions, or consulting a doctor for alternatives like dutasteride or RU58841.

community 13 Years Finasteride, Switched to Dutasteride - 25% increase in Total Testosterone (expected) but 150% increase in Free Testosterone?

in Finasteride/Dutasteride 25 upvotes 8 months ago

After switching from finasteride to dutasteride, the user experienced a 25% increase in total testosterone and a 150% increase in free testosterone, with side effects like brain fog and nipple tingling. The user plans to consult a lab for accuracy and adjust the dutasteride dosage to manage side effects.

community I hope ET-02 or PP405 will be released in the next 4-5 years

in Product 15 upvotes 1 year ago

PP405 is a potential hair loss treatment that may work by blocking signals that cause hair cells to stop growing, requiring daily application for effectiveness. It could serve as an alternative to minoxidil and finasteride, but it is not yet available on the market and may take several years to be released.

community Creatine made all my high DHT symptoms return

in Research/Science 81 upvotes 1 year ago

Creatine may increase DHT levels, potentially causing symptoms like acne, oily hair, and hair shedding. Users report mixed experiences, with some avoiding creatine due to hair loss concerns and others seeing no impact.

community Solving Hair Loss with Research at MIT

in Research/Science 595 upvotes 1 year ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community "but it will hurt my gains bro"

in Satire 1309 upvotes 1 year ago

The conversation humorously discusses hair loss treatments like Minoxidil, Finasteride, and Dutasteride, and their effects on hair and muscle gains. Users debate effectiveness and side effects, mixing scientific approaches with jokes.

community 9 months of minoxidil , finasteride, spironolactone, estradiol

in Progress Pictures 64 upvotes 1 year ago

User shared progress pictures after 9 months of using minoxidil, finasteride, spironolactone, and estradiol for hair loss. Significant regrowth was noted, especially after starting estradiol.

community This shit works like magic, aka 50 days on oral min&fin

in Progress Pictures 172 upvotes 1 year ago

A user shared their successful 50-day progress using oral minoxidil and finasteride for hair loss. They plan to switch to dutasteride after six months for potentially better results.

community We need to keep these snake oil companies accountable.

in Treatment 120 upvotes 2 years ago

Biotin is being misleadingly marketed as a primary treatment for androgenic alopecia, overshadowing more effective treatments like finasteride and minoxidil. There is a call for increased awareness and accountability to prevent misinformation.

community One year anti androgen update CROWN

in Finasteride/Dutasteride 338 upvotes 3 years ago

User used Finasteride, Dutasteride, and Minoxidil for one year to treat hair loss. They discussed possibly trying RU58841 or pyrilutamide in the future.