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      community P-1075: a BETTER version of Minoxidil

      in Research/Science 8 months ago
      P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

      community 200 days hair regrowth . Seeing some growth

      in Minoxidil  65 upvotes 1 year ago
      The user is using 2.5 mg oral minoxidil, rosemary essential oil with olive oil, biotin, folli hair tablets, and a rice water mask for hair regrowth. Another user inquired about finasteride, and others wished the user good luck and asked for updates.

      community Possible natural pp405 solution

      in Research/Science  45 upvotes 10 months ago
      Rotenone, a natural plant extract, may promote hair growth by increasing LDH activity and blocking MPC in the scalp, but it carries risks due to its toxicity. The suggested formulation includes Barbasco extract, DMSO, propylene glycol or PEG-400, ethanol, and a carrier oil.

      community [Nov 2019] The peptide AC 2 isolated from Bacillus-treated Trapa japonica fruit extract rescues DHT (dihydrotestosterone)-treated human dermal papilla cells and mediates mTORC1 signaling for autophagy and apoptosis suppression

       22 upvotes 6 years ago
      A peptide from Japanese water chestnut fruit may help with hair loss by suppressing DHT's effect on hair follicle cell death, potentially serving as a finasteride alternative. The treatment's effectiveness and safety in humans remain uncertain.

      community Experience with Spironolactone?

      in Female  7 upvotes 4 years ago
      Spudlady asks about experiences with spironolactone for hair loss. She has lost hair due to stress and seeks ways to stop shedding.

      community Black market pp405? Title title

      in Treatment  8 upvotes 5 months ago
      PP405 is likely fake, and JXL069 is an unrefined prototype with unknown side effects. It's advised to wait for the official PP405 release.

      community PP405 - hair stem cell stimulation

      in Research/Science  53 upvotes 2 years ago
      PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

      community Sea Salt Spray for Adding Thickness/Texture

      in Styling  5 upvotes 3 years ago
      Sea salt spray adds texture and volume to hair but can dry it out, so it's best used sparingly. Some users find it helpful for thicker-looking hair, while others suggest using it alongside other treatments for oily hair.

      community L. reuteri (probiotic for Androgenic Alopecia)

      in Finasteride/Dutasteride  34 upvotes 2 months ago
      L. reuteri, a probiotic, is being explored for its potential benefits in treating androgenic alopecia, possibly enhancing finasteride's effects and reducing inflammation. The user combines this with finasteride, oral minoxidil, and other supplements, noting some improvement in hair loss.

      community Coconut Oil + Castor Oil Hair Regrowth | YEAR 1.5

       14 upvotes 8 years ago
      The post and conversation discuss using coconut oil and castor oil for hair regrowth over 1.5 years. Some users suggest using finasteride, minoxidil, and RU58841 for better results, while others prefer natural oils to avoid side effects.

      community Ru58841 made my hair worse

      in General  138 upvotes 1 year ago
      RU58841 worsened hair condition, causing thinning and unusual patterns. The user stopped using it two months ago but hasn't seen recovery, and there's speculation about androgen receptor upregulation.

      community Anyone have any KX-826 results yet?

      in Product  14 upvotes 1 year ago
      KX-826 users report increased shedding, with some experiencing more shedding at higher concentrations. Users are discussing where to purchase the product.

      community So what exactly do coconut and castor oil even do?

      in Question  4 upvotes 7 years ago
      Coconut oil may act as a natural conditioner but can clog pores, while castor oil might promote hair growth and help with dandruff. Users suggest trying lighter oils like apricot or grapeseed for better results.

      community Nizoral and what other shampoo?

      in Ketoconazole  6 upvotes 5 months ago
      The conversation is about choosing a second shampoo to use alongside Nizoral for hair loss treatment. Suggestions include Nioxin, baby shampoo, Lipogaine, and Revita, with some users recommending letting the shampoo sit for a few minutes before rinsing.

      community will pp405 be able to bring my lost temple area back to the game?

      in Research/Science  10 upvotes 3 months ago
      A user is concerned about hair loss in the temple area despite using Minoxidil and finasteride for 10 months and is curious if PP405 can help. Responses indicate uncertainty about PP405's effectiveness, with some optimism about future treatments and AI speeding up drug discovery, but emphasize waiting for clinical trial results.

      community Pp405 full presentation on new topical

      in Product  105 upvotes 3 months ago
      A new topical treatment, PP405, shows promising results for hair regrowth, potentially outperforming existing treatments like finasteride and minoxidil. However, it may still need to be combined with DHT blockers for optimal results, and its long-term effectiveness remains uncertain.

      community New Breezula Update ( I think)

      in Treatment  18 upvotes 7 months ago
      Breezula's phase 3 enrollment for hair loss treatment is complete, but results have not been published, causing skepticism about its progress. Some users express doubt about its future, suggesting it may be reserved for exclusive use.

      community Breezula CB-03-01

      in Treatment  11 upvotes 6 years ago
      The conversation is about a potential new hair loss treatment called Breezula CB-03-01. Users are discussing updates on its development and sharing personal experiences with making or using it.

      community Any sources on Geranium sibiricum extract?

      in Product 4 years ago
      The conversation discusses the use of Minoxidil and finasteride for hair loss and explores the potential of Geranium sibiricum extract as a safer alternative. It highlights the difficulty in finding this specific extract and suggests considering other plants with similar compounds, like Indian gooseberry.

      community Cosmo Pharma 2025 Investor Day Report

      in Research/Science  7 upvotes 11 months ago
      Cosmo Pharma plans to release Breezula, a hair loss treatment, with expected FDA approval in 2027, but concerns arise over its high potential cost of $225/month. Users express skepticism about its effectiveness compared to cheaper alternatives like finasteride and minoxidil.