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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Anageninc RU58841 is legit & my experience

      in Research/Science  5 upvotes 2 years ago
      The user experienced side effects from RU58841, including dry eyes and potential eyesight issues, and decided to stop using it. They confirmed the product's legitimacy but advised caution due to its experimental status and lack of safety data.

      community The use of peptides to enhance hair growth from wounding

       5 upvotes 8 years ago
      The conversation discusses using peptides BPC-157 and TB-500, combined with microneedling, to potentially enhance hair regrowth. The user plans to try BPC-157 due to its lower cost and reports of hair growth, despite limited human trials and concerns about side effects from other treatments like minoxidil and finasteride.

      community 3 months progress 7/4 - 10/1

      in Finasteride/Dutasteride  69 upvotes 5 years ago
      A user reported improved hair thickness after using 1mg daily of finasteride, minoxidil foam twice daily, vitamin D, and biotin shampoo, and later reduced the finasteride dose to 0.5mg. They plan to provide another update at the 6-month mark.

      community Hair routine (all info listed)

      in Treatment  5 upvotes 3 years ago
      The user shares a hair loss routine involving finasteride, B-Complex vitamins with biotin, pumpkin seed oil, apple cider vinegar, aloe vera, honey water, olive oil, and tea tree oil. They emphasize avoiding shampoo and using natural rinses to maintain scalp health and promote hair growth.

      community The best vehicle/carrier for RU58841

      in Treatment  2 upvotes 2 years ago
      The conversation is about the best vehicle for RU58841, comparing trichosol and Garnier/Vichy Stemoxydine, avoiding propylene glycol (PG) or ethanol due to previous scalp damage. The user is also seeking sources for these products in the EU.

      community Redensyl formula recommendation

      in Product  2 upvotes 1 year ago
      A user is seeking a hair loss formula containing Redensyl and Capixyl without caffeine, Saw Palmetto, or other herbs. They want recommendations for such a product.

      community Pyri update after one month of use

      in Minoxidil  1 upvotes 3 years ago
      Hair loss treatment includes Minoxidil, Derma Rolling, PRP, Saw Palmetto, Vitamin D, and Pyri. After one month, Pyri caused penis numbness, tiredness, and reduced hair fall, but user stopped due to side effects.

      community 7 years on Fin… I’m tired of this

      in Progress Pictures  25 upvotes 1 year ago
      The user has been on finasteride for 7 years and had a hair transplant, but is experiencing hair thinning and itchiness, particularly on one side, leading to concerns about male pattern baldness or other health issues. Despite having a full head of hair, the user is considering shaving it due to mental health struggles and is advised to consult a therapist and consider other treatments like minoxidil or dutasteride.

      community Can we get a reality check on PP405?

      in Research/Science  81 upvotes 6 months ago
      PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.

      community PSA: If you're prone to MPB dont take creatine

      in Update  103 upvotes 2 years ago
      Creatine might speed up hair loss in those prone to male pattern baldness, possibly due to increased DHT levels. Some users experience no issues when using creatine with treatments like finasteride, minoxidil, or dutasteride.

      community What else is good. Besides the big 3.

      in Chat  35 upvotes 1 year ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community Looking for feedback on my new regimen

       4 upvotes 8 years ago
      The conversation discusses a hair loss regimen involving finasteride, dutasteride, minoxidil, RU58841, and various supplements like biotin, omega-3, vitamin D3, zinc, and magnesium. The user also uses dermastamping and topicals like ketoconazole and diclofenac, with mixed opinions on zinc's effect on hair loss.

      community Progress pictures over 7 months

      in Progress Pictures  51 upvotes 1 year ago
      The user reported modest hair improvement using 1 mg finasteride daily, topical minoxidil twice daily, and weekly microneedling over seven months. Other users discussed their own experiences and encouraged patience, with some suggesting additional treatments like dutasteride and dermarolling.

      community Black market pp405? Title title

      in Treatment  8 upvotes 3 months ago
      PP405 is likely fake, and JXL069 is an unrefined prototype with unknown side effects. It's advised to wait for the official PP405 release.

      community 10month fin/min - micro-needling and rosemary biotin & more

      in Minoxidil  635 upvotes 1 year ago
      The conversation discusses a hair loss treatment routine involving daily minoxidil, finasteride, micro-needling, rosemary oil, and biotin supplements. The user shares personal experiences, noting no side effects from finasteride and emphasizing the importance of a healthy lifestyle in preventing hair loss.

      community MY Hair Loss Treatment Summary

      in Treatment  10 upvotes 1 year ago
      The conversation is about various hair loss treatments, including finasteride, minoxidil, RU58841, and natural supplements like saw palmetto and pumpkin seed oil. It also covers methods to improve blood circulation, nourish hair follicles, and address underlying health issues like vitamin D deficiency and high cortisol levels.

      community Bryan Johnson used a customized formula by Roots byGA to restore his hair

      in Treatment  25 upvotes 1 year ago
      Bryan Johnson used a customized hair restoration formula from Roots byGA, which includes Minoxidil, Cetirizine HCl, Latanoprost, Dutasteride, Melatonin, Caffeine, Tretinoin, Vitamin D3, and Vitamin E. Many users are skeptical of the effectiveness and uniqueness of the treatment, suggesting that standard treatments like Minoxidil and Dutasteride are more reliable.

      community Update 7 months post op HT from Dr.Serkan Aygin 3100 total grafts…Topical Fin/Min + Men’s Viviscal,Biotin and it’s a 10 sulfate free shampoo mixed with Nizoral and I added donor area photos too this time. Enjoy and wish you the best.

      in Transplants  53 upvotes 3 years ago
      A 7-month update from Markoj44 regarding their hair transplant results, which includes the use of topical finasteride and minoxidil in combination with Viviscal, biotin, Nizoral shampoo, and donor area photos. People responded positively to the post.

      community a new supplement just released

       11 upvotes 8 years ago
      A dermatologist recommended a new supplement containing annurca apple, which reportedly doubles hair density and increases keratin after 60 days, to be used with finasteride. Some users are skeptical, considering it potentially ineffective or a marketing ploy, while others are open to trying it if it proves effective and affordable.