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      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Do we have anything in the pipeline that is used as a replacement for minoxidil?

      in Minoxidil  17 upvotes 1 year ago
      The conversation discusses hair loss treatments, focusing on alternatives to Minoxidil, such as Bimatoprost and Latanoprost, and the use of Finasteride, Dutasteride, RU58841, and microneedling. The user plans to add Latanoprost to their regimen, which already includes oral and topical Minoxidil and Finasteride, Ketoconazole shampoo, and microneedling.

      community having hair loss as a teen SUCKS. A LOT.

      in Female  12 upvotes 3 years ago
      A teenage girl who has been diagnosed with ADA and is struggling with hair loss, which has caused her to lose confidence. She is looking for recommendations on treatments such as finasteride or Minoxidil, and lifestyle advice including vitamins and other supplements that might help with the issue.

      community Found an interesting little article

      in Research/Science  5 upvotes 1 year ago
      A new painless microneedle patch shows promise in reversing hair loss. The discussion focuses on potential new treatments beyond common options like Minoxidil, finasteride, and RU58841.

      community Would you guys be interested in a pure cb-03-01 progress pick series?

      in Research  69 upvotes 6 years ago
      The conversation is about someone planning to use cb-03-01 for hair loss because they experience side effects with other treatments like finasteride, minoxidil, and RU58841. They have not found progress pictures online and are considering sharing their own experience with cb-03-01, which is expensive.

      community Will Fin+Min save me(6F) ?????

      in Satire  1481 upvotes 11 months ago
      Finasteride and minoxidil are discussed as hair loss treatments, with warnings about minoxidil's toxicity to cats. Suggestions include hair transplants, dutasteride, and humorous alternatives like red light therapy and rosemary oil.

      community Almost 2 month of 1mg fin and Costco min (liquid)

      in Is this regrowth?  83 upvotes 1 year ago
      A 40-year-old male using 1mg finasteride and Costco liquid minoxidil for almost 2 months reports noticeable improvement in hair regrowth, though his temples remain recessed. Encouragement from others suggests continued use will yield further progress.

      community 10 months on oral Fin + Foam Min

      in Progress Pictures  144 upvotes 2 years ago
      The post and conversation are about a user's progress with hair loss using oral finasteride and minoxidil foam. The user experienced new hair growth after 6-8 months and had to shave their head a few times, but continued taking the treatments and is happy with the results.

      community The dermaroller you didn't know you needed

      in Satire  35 upvotes 6 months ago
      A humorous discussion about a scalp massager used in a barber shop, with no mention of specific hair loss treatments like Minoxidil, finasteride, or RU58841. The massager is described as pleasurable but not a treatment for hair loss.

      community Anyone here used spirolactone/cyproterone acetate/bicalutamide?

      in Chat  4 upvotes 9 months ago
      The conversation discusses the use of spironolactone, cyproterone acetate, and bicalutamide for hair loss, with concerns about side effects like gynecomastia and depression. Topical spironolactone is considered safe for men and effective when combined with regular treatments.

      community Malassezia safe topical treatments?

      in Question  2 upvotes 7 years ago
      The user is seeking Malassezia-safe treatments for hair loss and currently uses a baby shampoo, a scalp tonic with antifungal ingredients, and aloe gel. They consider using Kirkland Minoxidil 5% drops and possibly consulting a doctor about Finasteride.

      community Shoutout to the mice that tested our Minoxidil

      in Satire  147 upvotes 1 year ago
      The conversation humorously acknowledges the role of mice in testing Minoxidil for hair loss while also discussing the ethics of animal testing. Some users argue against animal testing, citing cruelty, while others defend its necessity for medical advancements.

      community A miraculous drug that regrows body parts.

      in Research/Science  154 upvotes 4 months ago
      A drug that regrows body parts, but not hair, sparking debate on hair loss treatments. Discussions include the use of finasteride, dutasteride, and the potential for new methods to restore hair.

      community I quit oral min during in shedding phase

      in Minoxidil 6 months ago
      The user stopped using oral minoxidil due to shedding and is continuing with oral finasteride and hair vitamins. They are advised that shedding is temporary and to maintain finasteride use, with examples of others successfully managing hair loss with similar treatments.

      community RU and cetosomal minoxidil topical

      in Minoxidil  1 upvotes 4 months ago
      Mixing RU58841 with cetosomal minoxidil is discussed due to scalp irritation from ethanol PG vehicles. A mixture of the two turned bright pink when left to dry.

      community Half year update on crown balding reversal

      in Is this regrowth?  36 upvotes 6 months ago
      The conversation is about a user who started using finasteride to address crown balding, noticing reduced hair shedding and halted progression of male pattern baldness. The user also used a dermal stamp and expressed optimism about potential regrowth, despite a slight decrease in libido.

      community Best device for microneedling?

      in Microneedling  9 upvotes 2 years ago
      The conversation is about someone seeking advice on the best microneedling device to use for hair loss, mentioning pens, stamps, and rollers as options.

      community 18 month hairline progress pictures.

      in Progress Pictures  818 upvotes 1 year ago
      A user's 18-month hairline progress using minoxidil, finasteride, Nizoral, microneedling, and scalp massage. They share their routine and discuss treatment effectiveness and photo order confusion.

      community Needling project, I'm needling half of my head

      in Microneedling  1 upvotes 1 year ago
      A person is experimenting with microneedling on one temple while using Minoxidil to address hair loss. They plan to needle weekly and apply Minoxidil twice daily, avoiding application around needling sessions.

      community Eucapil, Fluridil update from manufacturer

      in Treatment  5 upvotes 11 months ago
      The user is experiencing hair loss after a hair transplant and is considering using fluridil (Eucapil) and possibly alfatradiol as treatments, as they couldn't tolerate finasteride or minoxidil. The manufacturer of Eucapil confirmed they won't produce higher concentrations due to lack of efficacy.

      community What happened to Breezula ????

      in Research/Science  12 upvotes 3 years ago
      The conversation discusses the effectiveness of a hair loss treatment called CB (Breezula) in comparison to Pyrilutamide, and its potential when combined with Finasteride. There is uncertainty about when or if phase 3 trials for Breezula will begin.

      community Oral DUT 0.5/ Oral MIN 5mg daily + occ MN

      in Progress Pictures  55 upvotes 2 months ago
      The user experienced hair recovery using oral dutasteride 0.5 mg and oral minoxidil 5 mg daily, considering increasing dutasteride dosage but concerned about cost and effectiveness. They noted progress and discussed alternatives like hair transplants and other medications.

      community What's an anecdotal treatment you nevertheless swear by?

      in Product  11 upvotes 1 year ago
      Stemoxydine is highly recommended for hair loss, preferred over Minoxidil due to fewer side effects and dependency. The user also uses finasteride, Pur'ador shampoo, and suggests cold showers and spicy food as part of their routine.

      community Anyone else experiencing scalp inflammation? Get in here!

       5 upvotes 7 years ago
      A user found that taking Zyrtec (Cetirizine) and Advil helped reduce their scalp inflammation and pain, potentially creating a better environment for hair growth. They have not used any other medication for hair loss or scalp issues.