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GlossaryPAPA Syndrome

rare genetic disorder causing arthritis, skin ulcers, and severe acne

PAPA Syndrome, or Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne Syndrome, is a rare genetic disorder characterized by recurrent episodes of joint inflammation (arthritis), painful skin ulcers (pyoderma gangrenosum), and severe acne. It is caused by mutations in the PSTPIP1 gene, which affects the immune system and leads to excessive inflammation.

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community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community I just made my own PRP - DIY PRP

in Research/Science 552 upvotes 2 years ago

The post and conversation are about a user who made their own Platelet-Rich Plasma (PRP) for hair loss treatment at home, using their own blood and a centrifuge. The responses vary, with some users supporting the DIY approach to save money, others expressing concern about the safety and effectiveness of the method, and a few joking about the lengths people will go to combat hair loss.

community Dut kept my hair but nuked my peepee

in Finasteride/Dutasteride 101 upvotes 5 months ago

A user experienced hair retention but sexual side effects after using dutasteride for a year. Others shared similar experiences with finasteride and dutasteride, suggesting consulting a doctor for persistent issues.

community A man in his 80s with full head of hair.

in Chat 467 upvotes 2 months ago

Genetics play a major role in hair loss, with some people keeping a full head of hair into old age without using treatments like minoxidil or finasteride. Many express frustration over their own hair loss and the perceived unfairness of genetic differences.

community 3,5 months of only topical minoxidil

in Minoxidil 784 upvotes 6 months ago

A 24-year-old reported new hair growth on temples after 3.5 months of using topical minoxidil without shedding. They plan to add finasteride to maintain progress, as minoxidil alone may not be enough long-term.

community 10 Days Post-Op: Hair Transplant Results and Experience

in Progress Pictures 507 upvotes 2 years ago

A user shared their positive experience with a hair transplant at Dr. Resul Yaman Hair Clinic in Istanbul, including before and after photos. They are considering taking oral Minoxidil post-operation but are avoiding Finasteride due to side effects.

community This guy loses all transplanted hair?!

in Transplants 160 upvotes 2 years ago

A man lost his transplanted hair despite using minoxidil because he wasn't on a DHT blocker like finasteride, which is essential to prevent further hair loss. The conversation emphasizes that hair transplants are not a cure and require maintenance with medications to preserve results.

community 4 months progress. Hims spray. 6% min, 0.3% fin. Also .25mm dermaroller 2x a week.

in Progress Pictures 255 upvotes 3 years ago

A user's successful 4-month hair growth progress using Hims spray with 6% Minoxidil, 0.3% Finasteride, and a .25mm dermaroller twice a week. The user applies the spray once a day and has not experienced any side effects.

community Am I taking out too much foam for a dose? Rogaine Minoxidil

in Minoxidil 3 years ago

This conversation discusses the topical application of Minoxidil, with various users providing advice on how to accurately measure a dose and keep it from melting too quickly. Others have shared their experiences using oral finasteride for hair loss treatments.

community Father trying to save his 17 year old son from MPB

in Progress Pictures 160 upvotes 4 years ago

Father assists son with hair loss using Finasteride Propecia. Son's hair improves, considers adding Minoxidil or Dutasteride for better results.

community The Hormonal Profile of MPB/AGA

in Research/Science 9 upvotes 5 years ago

Men with early male pattern baldness (MPB) may have hormonal abnormalities similar to those in women with PCOS. Specific treatments mentioned include Minoxidil, Finasteride, and RU58841.

community I have Post PP405 Syndrome(PPS). Should I start a foundation?

in Satire 33 upvotes 1 year ago

The conversation humorously discusses the fictional "Post PP405 Syndrome" and the idea of starting a foundation or cult around it. It mentions skepticism about the effectiveness of PP405 and jokes about future therapies.

community Interesting new publication suggesting that MPB should be assessed as a early warning sign for type-2 diabetes.

14 upvotes 8 years ago

Male pattern baldness (MPB) may be an early warning sign for type 2 diabetes due to its association with insulin resistance. Treatments discussed include testosterone therapy and finasteride, which affects hormone levels related to hair loss and insulin sensitivity.

community Just found out my dad is not my dad and my bio dad is bald

in Chat 73 upvotes 8 months ago

A person is struggling with hair loss and mental health issues, using treatments like dutasteride and minoxidil, and planning a hair transplant. They recently discovered their biological father is bald, causing additional stress, but are encouraged by others to focus on their treatment success and seek professional help for their mental health.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 50 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community DUPA - Impossible to cure, so giving up

in Update 3 upvotes 9 months ago

The user diagnosed with DUPA tried treatments like dutasteride, finasteride, RU58841, and minoxidil without success and is considering a hair system. They hope for a future cure, possibly with PP405, and others suggest options like scalp biopsy and SMP.

community Balding while your father has a full head of hair must suck

in Finasteride/Dutasteride 261 upvotes 1 year ago

Unexpected hair loss despite family members having full hair. Treatments include finasteride, minoxidil, and dutasteride.

community So it turns out Post Finasteride Syndrome was never real?

in Finasteride/Dutasteride 271 upvotes 1 year ago

Post Finasteride Syndrome (PFS) is debated, with some users reporting severe side effects from finasteride, while others believe these effects are rare or psychosomatic. Treatments discussed include finasteride, minoxidil, and RU58841.

community Severe Hair Loss Post-Surgery and Stress, Possible DUPA or Alopecia?

in General 64 upvotes 7 months ago

The user is experiencing severe hair loss after surgery and stress, with thinning all over the head, including the sides and neck. They are unsure if it's due to DUPA or alopecia areata incognita, and doctors have not observed miniaturization.

community A Summary of the Latest Research regarding PFS, and How Supplementing Allopregnanolone Might Protect Against It

in Chat 4 upvotes 2 years ago

Post Finasteride Syndrome (PFS) may result from epigenetic changes and gut microbiota alterations. Supplementing with Allopregnanolone might protect against these adverse effects.

community any news about DUPA (Diffuse unpatterned alopecia)?

in Research/Science 8 upvotes 3 years ago

The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

community Can't tell if I'm balding, or simply inheriting my father's bizarre hairline - please let me know your thoughts [33M]

9 upvotes 12 years ago

A 33-year-old man is concerned about potential hair loss, comparing his hairline to his father's and noticing increased shedding and thinning. He is considering treatments like Minoxidil and Finasteride but is unsure if he has male pattern baldness.

community Why I believe PFS is not a "real" condition (and what I believe it is instead)

in Finasteride/Dutasteride 15 upvotes 3 years ago

The post argues that Post-Finasteride Syndrome (PFS) is likely not real and suggests symptoms may be due to mental health issues or the nocebo effect. The conversation includes personal experiences with finasteride, highlighting both positive and negative effects, and emphasizes consulting doctors and using reliable sources for medication.

community 80-year-old with his 99-year-old father have more hair than I did at 15

in Satire 1016 upvotes 3 months ago

An 80-year-old man and his 99-year-old father have more hair than many younger people, sparking discussions about hair loss and genetics. The suggested treatment for maintaining hair is simply eating oysters.

community Post Finasteride Syndrome, A dangerous lie.

in Chat 142 upvotes 2 years ago

A user initially had side effects from finasteride, attributed them to anxiety and the nocebo effect, and after resuming the drug, experienced positive effects and now warns against misinformation about Post Finasteride Syndrome.

community scarring alopecia awareness in this community

in Chat 33 upvotes 3 years ago

Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

community Anger and frustration as I finally learn my diagnosis.

in Female 6 upvotes 2 years ago

A young female diagnosed with Lichen planopilaris (LPP) experienced years of misdiagnosis and ineffective treatments, including a hair transplant and other procedures. She is considering litigation due to the misdiagnosis and has learned that LPP is chronic, hair loss can be stopped with ongoing medication, but lost hair cannot regrow.

community Compared to the hair of your father at your age how is your hair doing?

in Finasteride/Dutasteride 29 upvotes 3 years ago

How people's hair is compared to their fathers' at the same age, with some users noting that they have inherited different genes from either parent and are using treatments such as finasteride for hair loss.

community Why does MPB only affect the scalp

in Research/Science 14 upvotes 1 year ago

Male pattern baldness (MPB) may be influenced by androgen receptors in scalp hair follicles and potentially poor blood flow. Transplanted hair is not immune to DHT, and factors like inflammation and scalp tension might also contribute to hair loss.

community I've been afflicted by post finasteride syndrome, what now?

in Finasteride 38 upvotes 7 years ago

A user experienced severe side effects from finasteride, including mental health issues and physical symptoms, and sought advice on managing post-finasteride syndrome. Suggestions included checking vitamin levels, considering dopamine agonists, and avoiding further psychiatric medications.