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GlossaryPharmacogenetics

study of how genes affect individual responses to medications

Pharmacogenetics is the study of how an individual's genetic makeup affects their response to drugs. This field aims to tailor medical treatments to each person’s genetic profile, enhancing drug efficacy and minimizing adverse effects. It is also known as pharmacogenomics, and involves testing specific genes to predict how a patient will respond to certain medications.

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community Pelage have presented only phase 2a. The rest of phase 2 for PP405 will be presented at a later medical meeting

in Chat 29 upvotes 2 weeks ago

PP405's phase 2a trial results were presented, focusing on safety and pharmacokinetics, with a future meeting planned to share the full dataset. The trial includes a randomized controlled portion and an open-label extension, with no indication of phase 2B completion.

community Are we underestimating systemic absorption with homemade/generic Topical Fin? (HPCH vs. PG/Ethanol formulations)

in Research/Science 4 upvotes 2 months ago

Topical finasteride may have higher systemic absorption and lower efficacy when using a Propylene Glycol/Ethanol formulation compared to the hydroxypropyl chitosan (HPCH) formulation. The safety profile of topical finasteride relies heavily on the HPCH formulation, and using standard solutions might lead to different pharmacokinetics.

community When to switch from finasteride to dutasteride and how long to wait for dutasteride to build up

in Finasteride 137 upvotes 4 months ago

The user is considering switching from finasteride to dutasteride for hair loss treatment and is unsure when to stop finasteride. Dutasteride takes about 15 days to reach significant DHT suppression compared to finasteride.

community Effectiveness of Dutasteride 0.5mg: Scalp vs Follicle DHT Reduction for AGA

in Treatments 97 upvotes 5 months ago

Dutasteride 0.5 mg significantly reduces both scalp and hair follicle DHT, with a greater reduction in hair follicle DHT. The discussion questions which reduction is more important for androgenetic alopecia and diffuse thinning.

community DHT reduction in the scalp for all doses of dutasteride is now available.

in Finasteride/Dutasteride 357 upvotes 10 months ago

Higher doses of dutasteride reduce scalp DHT more effectively than finasteride, but have diminishing returns after 3mg daily and may cause more side effects. Combining dutasteride with topical minoxidil can enhance results, but using both finasteride and dutasteride together is unnecessary.

community Switching to Oral from Topical min effective or not

in Minoxidil 6 upvotes 1 year ago

Switching from topical to oral minoxidil may lead to better results for some users, with oral minoxidil generally being more effective due to higher absorption. However, it can also cause side effects like hypertrichosis and blood pressure issues, and individual responses may vary.

community Methods Of Staying Safe On Ru58841 - My 2 Cents

in Research/Science 21 upvotes 1 year ago

RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

community Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)

in Research 598 upvotes 1 year ago

A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.

community Research Backed Dutasteride Simulator (Serum/Scalp DHT included for all doses)

in Finasteride/Dutasteride 115 upvotes 1 year ago

A dutasteride simulator predicts that daily 0.5 mg dosing results in higher DHT suppression compared to less frequent dosing. Twice-weekly dutasteride may be as effective as finasteride 5 mg, providing a balance between efficacy and ease of use.

community Doc suggested to start using Fin

in Treatment 181 upvotes 1 year ago

A user is seeking advice on hair loss treatment and has been prescribed finasteride. They currently use minoxidil, rosemary oil, and castor oil, and are considering adding dermarolling. Respondents suggest daily use of minoxidil and finasteride, with some recommending additional treatments like ketoconazole shampoo, dermapen, dutasteride, and vitamins.

community Dutasteride Vs. Testosterone, who wins?

in Finasteride/Dutasteride 58 upvotes 2 years ago

The conversation discusses whether 2.5mg of dutasteride or 200mg of testosterone weekly is more influential in preventing hair loss, with various personal experiences indicating that the effectiveness is dependent on the individual's genetic profile. Some users report that dutasteride is likely to be more effective at the given doses.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 43 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Seeking Advice on Dutasteride and Oral Minoxidil Effectiveness After 1 Year, Considering Finasteride

in Basic Questions 129 upvotes 3 weeks ago

The user is experiencing continued hair loss despite using dutasteride and oral minoxidil, and is considering adding finasteride or adjusting their current treatment. They are seeking advice on whether to change their approach due to lack of improvement, especially at the temples and crown.

community How much scalp dht does dutasteride 1mg, 1.5mg, and 2mg block?

in Finasteride/Dutasteride 12 upvotes 2 months ago

Dutasteride at 0.5mg blocks 50% of scalp DHT, while higher doses like 1mg and 2.5mg block more, with 2.5mg blocking up to 80%. Some users report better results with lower doses, and there's confusion about the effectiveness of different dosages on scalp versus serum DHT.

community The fact 2.5mg Dutasteride pills don't exist is f*cking ridiculous (RANT)

in Finasteride/Dutasteride 4 upvotes 5 months ago

The conversation discusses the frustration over the unavailability of 2.5mg dutasteride soft gels, with some users suggesting higher doses for better scalp DHT suppression. Concerns about side effects and the necessity of DHT are debated, with some users advocating for alternative treatments like RU58841 and oral minoxidil.

community Trying intermittent Dutasteride (0.5mg every 5-6 days)

in Basic Questions 165 upvotes 5 months ago

A 22-year-old male experienced hair regrowth using an intermittent Dutasteride regimen, oral and topical Minoxidil, FolliHair AM/PM, and Salicia KT shampoo. He stopped Dutasteride due to side effects like dry eyes and skin, but noticed increased hair shedding after stopping.

community PP405 2a study was a safety study. Some rational explaining.

in Research/Science 22 upvotes 7 months ago

The conversation discusses the safety study of PP405, emphasizing that early trials focus on safety rather than efficacy, and that any efficacy data from such a short study should be viewed skeptically. It also highlights that the information released is primarily for securing funding, and that meaningful efficacy results are expected in later phases.

community How many years can we expect PP405 to be on the market

in Product 12 upvotes 8 months ago

PP405 is expected to be on the market between 2027 and 2030, with phase 3 trials starting in 2026. There is skepticism about its fast-tracking due to its cosmetic nature, and it may appear on the gray market sooner.

community Dutasteride 0.5mg every 5 days

in Finasteride/Dutasteride 2 upvotes 8 months ago

The user is using 5% Minoxidil and 0.1% topical Finasteride and is considering adding 0.5mg Dutasteride every 5 days to stabilize hair regrowth. Consistency with treatment is advised, and there is no strong evidence linking Finasteride or Dutasteride to fertility issues.

community What’s better dutasteride or finasteride?

in Finasteride/Dutasteride 27 upvotes 9 months ago

Dutasteride is seen as more effective than finasteride for hair loss but may have more side effects and a longer half-life. Some start with finasteride for fewer side effects, while others switch to dutasteride for better results.

community DUT 0.5mg I need help from the experienced please!

in General 128 upvotes 9 months ago

The user is considering starting dutasteride (DUT) 0.5mg for hair loss due to lack of access to finasteride and is concerned about potential side effects. They seek guidance on whether to begin this treatment.

community Pp405 phase 2a clinical results

in Research/Science 38 upvotes 9 months ago

PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.

community When could we expect pp405 to hit the market?

in Research/Science 31 upvotes 11 months ago

PP405 is expected to finish Phase 2 trials in late 2025, with potential market availability around 2028-2029 if all goes well. Current treatments like finasteride and minoxidil are still popular, while new options like KX-826 and Breezula are anticipated soon.

community Mental Health and Finasteride Questions

in General 162 upvotes 1 year ago

A 20-year-old with anxiety and depression is considering finasteride for hair loss but is worried about potential side effects. They decide to consult a doctor and consider starting with a low dose, while also exploring topical finasteride as a potentially safer option.

community Switched Finasteride Brands, Hair, Scalp and Skin Declining

in Finasteride/Dutasteride 10 upvotes 1 year ago

Switching finasteride brands from Teva to Proscar led to hair and skin issues, suggesting possible differences in effectiveness or quality. Users recommend returning to the original brand that worked well.

community Realistically, how much PP405 will cost?

in Treatment 27 upvotes 1 year ago

PP405 is in phase 2 trials for hair loss, with discussions on its cost and effectiveness compared to minoxidil and finasteride. Users are skeptical about its efficacy and timeline, with hopes for market release by 2027.

community I interviewed Kintor: GT20029 Clinical Trial Pictures. As well as KX826.

in Research/Science 156 upvotes 1 year ago

GT20029 and KX826 are promising hair loss treatments, with GT20029 increasing hair count and KX826 showing significant results. KX826 may be a good alternative for those who can't use finasteride or dutasteride, though results vary.

community Estradiol mesotherapy / idea feedback

in Female 7 upvotes 1 year ago

The conversation discusses using estradiol mesotherapy to replicate hormone replacement therapy results while minimizing systemic exposure. It also covers the use of Spironolactone cream, which reportedly has no systemic side effects, and the potential risks of using bicalutamide and Spironolactone in men.

community Incredible results after just 1 month on dutasteride and minoxidil!

in Progress Pictures 108 upvotes 1 year ago

A user reported significant hair improvement after one month of using dutasteride and oral minoxidil. Others expressed skepticism, attributing perceived changes to lighting and styling, and debated the effectiveness and risks of these treatments.

community Fin/Dut and Metabolism Speeds…

in Finasteride/Dutasteride 8 upvotes 1 year ago

A user speculates that a fast metabolism might affect the effectiveness of dutasteride for hair loss. Another user argues that drug response is unrelated to metabolism speed.