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540-570 / 1000+ resultscommunity Gains and losses, near 3 year journey, recession and diffuse thinning. Been on finasteride for 3 years and switching to dutasteride and oral minox. May start topical min again soon
A 3 year journey of hair loss, with recession and diffuse thinning; the user has been taking finasteride for 3 years and is now switching to dutasteride and oral minoxidil, and may start using topical minoxidil soon.
community Am I losing my mind or should I be concerned
The user switched from topical to oral finasteride and minoxidil for hair loss and experienced swelling and sensitivity in the left chest area. They are concerned about these symptoms but noticed improvement after skipping a dose.
community Boss Fight. Temples, Hairless for 10 years vs. New Stack
User shares new hair growth stack including oral minox, daily rolling with minox application, niacin, and Dutasteride. Excited about progress and plans to update in two months.
community Effect of melatonin on aromatase expression
Melatonin's effect on aromatase expression is unclear, with studies showing both increases and decreases. Hormonal impacts are complex and inconsistent, similar to changing health advice on other substances.
community Anyone actually stuck with Dutasteride after switching from Finasteride?
The conversation discusses switching from finasteride to dutasteride for hair loss treatment, with mixed experiences regarding shedding and effectiveness. Some users also mention using minoxidil and RU58841 alongside these treatments.
community Can HMI-115 reverse miniaturization?
HMI-115, a potential treatment for hair loss that can reverse miniaturization and make individual hairs thicker, as evidenced by data from macaques given the treatment and one subject in the phase I trial.
community Haïr différence after 1 year dut with alternate days
The user experienced hair thickening and regrowth using dutasteride on alternate days, oral minoxidil every third day, and daily hair massages, but is dealing with dandruff and inflammation. They are considering adjusting their minoxidil dosage and have started using ketoconazole shampoo and cupping therapy for additional benefits.
community Ted Kaczynski had more hair than all you mfs before his death at 81
The conversation is about hair loss and the conclusion is that genetics play a significant role in hair loss, and lifestyle choices or being a well-adjusted person do not prevent male pattern baldness.
community 6 months on minoxidil shedding again
community Getting blindsided by atypical aggressive form of androgenetic alopecia in early 20s and realizing it's too late is one of the Top 10 worst male Experiences of all time
A young man faces severe hair loss in his early 20s, using treatments like dutasteride and minoxidil with little success, impacting his self-esteem and relationships. He considers hair systems and therapy as potential solutions.
community 17M with Diffuse Thinning, Dandruff, and Body Hair Shedding
A 17-year-old is experiencing diffuse thinning, dandruff, body hair shedding, and other symptoms, possibly linked to seborrheic dermatitis or telogen effluvium. They are using ketoconazole shampoo and considering blood tests to check for thyroid issues or deficiencies.
community Topical Dutasteride (Switching from Oral) Proven results
Switching from oral to topical dutasteride may reduce side effects like anxiety and depression while maintaining hair health. Combining it with minoxidil, Nizoral, and dermarolling could be effective for hair preservation.
community After 4 months of DREAD SHED it seems to have ended!
The user experienced a severe hair shedding phase after switching to a combination pill of finasteride, minoxidil, and B12, but the shedding has now significantly reduced. Other users shared similar experiences, noting that shedding can be a sign of treatment effectiveness.
community HLT Megathread on HMI-115 (key takeaways in comments)
HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.
community Functional hair follicles grown from stem cells: Scientists have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry.
Scientists have grown natural-looking hair from stem cells, potentially revolutionizing hair growth treatments. Concerns include cost, DHT resistance, and the need for future procedures.
community Cold and Japanese researchers. The Japanese began to suspect something. But they understood the mechanism to some extent. ( Cold shock therapy promotes hair growth in association with upregulation of cold-inducible RNA-binding protein and vascular endothelial growth factor).
Cold shock therapy may promote hair growth, but cold alone is not effective. Combining treatments like minoxidil, finasteride, cold showers, spicy foods, and exercise may enhance results.
community Pelage, PP405, is creating a database for potential new trial volunteers
PP405 is a new hair loss treatment targeting dormant hair follicles, with ongoing trials. Some users consider stopping finasteride and minoxidil to join trials, while others doubt its effectiveness.
community Is it possible to quit min and keep using fin without permanent damage?
An 18-year-old male is considering stopping minoxidil on the crown while continuing finasteride due to increased shedding and concerns about thinning. He seeks advice on safely switching to using minoxidil only on the hairline without risking permanent crown thinning.
community Non fin/min way to ONLY maintain?
community Any chemists want to manufacture PP405 / JXL069? (Steps inside)
The conversation discusses the synthesis and potential use of JXL069 and PP405 for hair loss treatment, with skepticism about their effectiveness and concerns about safety. Users mention that JXL069 has shown no results in hair growth, and there is confusion about its identity and effectiveness compared to PP405.
community Finally regrowth on the crown of my head after five years and switch to Dut!
After five years of no progress with hair regrowth using oral finasteride and topical minoxidil, a person switched to a combination of topical dutasteride, minoxidil, tretinoin, ketoconazole, and hydrocortisone in November 2023 and finally saw results. They had previously experienced side effects like gynecomastia from finasteride.
community Proof that scrolling endlessly can pay off.
The conversation humorously discusses the journey of deciding to use finasteride for hair loss, with a focus on a funny Facebook post. It also touches on the idea of promoting finasteride use to future generations.
community For everyone buying 2-deoxy-d-ribose (2ddr)
The conversation discusses using 2-deoxy-d-ribose (2DDR) for hair regrowth, with users sharing mixed experiences and side effects like hair loss in new areas and increased anxiety. The original poster plans to continue testing and comparing it to minoxidil, noting potential instability in 2DDR formulations.
community Will Pelage include Norwood 7 hair loss in PP405 phase 3 trials to see its true regenerative potential?
Norwood 7 hair loss is often excluded from trials to ensure treatments appear more effective and to reduce costs. Some believe treatments effective for Norwood 5 could work on Norwood 7, but companies prioritize market readiness.
community Reevaluating Finasteride/RU After 4 Months: Should I Switch to Dut?
The user is considering switching from finasteride and RU58841 to dutasteride due to ongoing hair loss concerns. They are unsure if the hair loss is due to shedding or worsening condition.
community How to switch from finasteride to dutasteride/oral min
The conversation is about switching from finasteride to dutasteride and oral minoxidil for hair loss treatment. The user is concerned about the shedding phase and is advised to start with dutasteride.
community I am 20 years old male and my hair is prematurely graying since I first notice bald spots. Any chances of it reversing back to my natural hair color?
A 20-year-old male experienced bald spots and used minoxidil, which led to hair regrowth but also premature graying. He seeks advice on reversing graying through diet or supplements like catalase, while another user suggests vitamin D3 and sesame for hair color.
community RU58841 vs. KX-826 vs. CB-03-01
community What factors cause more regrowth for MTF people with hormone replacement therapy?
Hair regrowth in transfems is more effective due to hormonal changes, specifically estrogen, which keeps hair in growth phase longer. Treatments mentioned include anti-androgens, sex hormones, and DHT blockers like finasteride.