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community DUPA, Non Responders and Connective Tissue Disorders

in Research/Science 9 upvotes 10 months ago

A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.

community Pelage curing hair loss with PP405 could become one of the most famous discoveries in history

in Chat 175 upvotes 2 weeks ago

PP405 is discussed as a potential treatment for hair loss, with excitement about its promise but skepticism about its current effectiveness. Users mention combining it with treatments like minoxidil, finasteride, and microneedling, but emphasize it is not a cure.

community An unusual case (progress or not?)

in Is this regrowth? 25 upvotes 8 months ago

A 43-year-old with a history of hair transplants and long-term finasteride use reports seeing hair regrowth after adding oral minoxidil, micro-needling, and resuming topical minoxidil. Users agree that the hair appears thicker and denser.

community When could we expect pp405 to hit the market?

in Research/Science 31 upvotes 11 months ago

PP405 is expected to finish Phase 2 trials in late 2025, with potential market availability around 2028-2029 if all goes well. Current treatments like finasteride and minoxidil are still popular, while new options like KX-826 and Breezula are anticipated soon.

community Will PP405 work if even dutasteride / fin failed to halt hair loss?

in Finasteride/Dutasteride 7 upvotes 3 weeks ago

The conversation discusses the ineffectiveness of dutasteride in halting hair loss for the user and explores the potential of PP405, which works through a different mechanism. Suggestions include considering a biopsy to determine the cause of hair loss and exploring other treatments like RU58841.

community Heads Up on Future Study: "Influence of Creatine Monohydrate Supplementation on Androgens and Global Hair Assessments"

in Research/Science 22 upvotes 5 years ago

Creatine supplementation may increase DHT levels, potentially affecting hair loss. A study is examining this effect, with participants taking 5 grams of creatine daily for six months.

community 16, female, losing a ton of hair

in Female 7 upvotes 1 year ago

A 16-year-old female experiencing severe hair loss and sebum buildup, likely due to telogen effluvium and PCOS, is currently using vitamin D3 supplements, Redenser serum, and T follihair supplements. Recommendations include addressing PCOS first and consulting a doctor.

community PP405 is NOT gray market jxl069

in Technology 26 upvotes 2 months ago

PP405 is a safer alternative to JXL069 for hair loss treatment because it penetrates the skin effectively and degrades in the blood, avoiding systemic toxicity. JXL069, when forced into the body, can cause dangerous side effects like lactic acidosis due to its inability to degrade safely.

community Has anyone tried Topical oxytocin?

in Treatment 2 years ago

A user reported less hair shedding using melatonin spray and is considering trying topical oxytocin or estrogel for hair growth, but is concerned about potential side effects like breast development. Topical oxytocin has been found to promote hair growth by increasing growth factors.

community (Serious) Updates and discussion, new treatments in development

in Treatment 7 upvotes 1 year ago

Finasteride, minoxidil, and derma rolling are currently the best treatments for hair loss. New treatments like TDM-105795, GT20029, PP405, HMI 115, Tsuji, Scube 3, RU, JW0061, Topilutamide, and verteporfin show promise but have uncertain timelines.

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