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GlossaryPinacidil

Pinacidil is a potassium channel opener that has been studied for its potential role in promoting hair growth and treating hair loss. It works by enhancing blood flow to hair follicles and may stimulate hair regrowth by prolonging the anagen (growth) phase of the hair cycle. Unlike other hair loss treatments, pinacidil is not a topical minoxidil derivative but shares similar mechanisms in promoting vasodilation and improving follicular health. Its relevance lies in its potential as an alternative or adjunct therapy for conditions like androgenetic alopecia.

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community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)

in Technology 13 upvotes 8 months ago

Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.

community Creatine is the opposite of minoxidil !

in Research/Science 315 upvotes 7 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community P-1075: a BETTER version of Minoxidil

in Research/Science 7 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community Sustaining minoxidil dependent hairs?

in Research/Science 9 upvotes 2 years ago

Minoxidil-dependent hairs fall out if minoxidil is stopped. New treatments like GT20029, FOL055, or TDM105795 might help sustain these hairs.

community 28M experiencing thinning - first timer here, please help

in Treatments 370 upvotes 6 months ago

A 28-year-old male experiencing hair thinning is considering minoxidil and finasteride. Minoxidil helps regrow hair, while finasteride prevents further loss; both are usually lifelong treatments.

community What’s the update on Pyrilutamide?

in Chat 12 upvotes 3 years ago

Pyrilutamide is seen as a last hope for those who can't take finasteride, with promising results reported. However, there's uncertainty about the quality and consistency of Pyrilutamide from black market sources.

community pyrilutamide phase 2 results right here, thanks to user Glaringbooch

in Chat 43 upvotes 4 years ago

Pyrilutamide, a new drug being tested to combat hair loss that has been found to perform comparably or better than finasteride and dutasteride in the initial 6 months of treatment with minimal reported side effects.

community Pyrilutamide is available at Minoxidilmax

in Research/Science 58 upvotes 3 years ago

Minoxidilmax offering a 0.5% Pyrilutamide solution and debating the cost, effectiveness, and safety of using it alone or with other treatments such as Finasteride and Minoxidil.

community Fluridil solution at Actifolic

in Treatment 4 upvotes 3 years ago

Fluridil, also known as Topilutamide or Eucapil, is discussed as a treatment for hair loss. It is noted as an androgen receptor antagonist, not a vasodilator.

community pyrilutamide – did anybody had any success on it?

in Finasteride/Dutasteride 15 upvotes 3 years ago

Potential success with the hair loss treatment Pyrilutamide, and possible group buying opportunities for it along with other treatments such as Finasteride and Minoxidil.

community What happened to Pyrilutamide?

in Technology 1 upvotes 1 year ago

Pyrilutamide's 0.5% solution showed minimal improvement, while the 1% solution appears more promising but costly. The user is currently using finasteride and oral minoxidil and considering adding Pyrilutamide if effective and affordable.

community My experience with Pyrilutamide

in Update 3 upvotes 2 years ago

The user experienced a slight decrease in hair shedding and scalp itch, and reduced sebum production using Pyrilutamide, but stopped due to chest pain, breathing difficulties, and heart issues. They felt normal a week after discontinuing and doubted FDA approval for the drug.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 126 upvotes 2 years ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.

community Any experiences with pyrrolidinyl diaminopyrmidine oxide (marketed as triaminodil, nanoxidil, vividine, but NOT aminexil/kopexil, it's something different) when compared to minoxidil?

in Minoxidil 1 upvotes 3 years ago

The conversation discusses the use of pyrrolidinyl diaminopyrmidine oxide (triaminodil) compared to minoxidil for hair loss treatment. The user is considering switching from 5% minoxidil to a product containing 5% triaminodil.

community Pyrilutamide - Worth it if can’t use Fin?

in Research/Science 4 upvotes 1 year ago

Pyrilutamide is being discussed as an alternative for those who can't use finasteride, but users report it may be ineffective at low concentrations. Some users are combining it with minoxidil, microneedling, and other treatments, but results vary.

community Pyrilutamide available at Actifolic now

in Research/Science 15 upvotes 3 years ago

Pyrilutamide, a new hair loss product with the potential to be more effective than RU58841 and safer than CB, but expensive.

community pyrilutamide solution progress log

in Product 20 upvotes 3 years ago

A 28 year old using a hair loss prevention protocol to restore thinning hair, which includes finasteride, dutasteride, minoxidil, stemoxydine, alopecin, nizoral shampoo and microneedling; the user is now adding pyrilutamide solution to the regimen with the hope of improving their results. RU58841 was also ordered but not yet used.

community Minoxadil 5% wv topical only? Experienced sides on 1mg fin and ~0.25mg fin. Solutions from here

in General 80 upvotes 1 year ago

The user experienced sexual side effects from finasteride and switched to using only topical minoxidil without side effects. They are seeking alternatives to finasteride, such as topical finasteride, to maintain hair without adverse effects.

community Alpicort E: Diffuse thinning/MPB medication, Can't find much info on it?

in Treatment 2 upvotes 2 years ago

A user was prescribed Alpicort E, which contains Estradiol Benzoate, Prednisone, and Salicylic Acid, for hair loss and is seeking others' experiences due to concerns about potential side effects.

community A Technical Question About Pyrilutamide

in Research/Science 5 upvotes 2 years ago

Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

community I'm very skeptical about pyrilutamide

in Product 2 upvotes 3 months ago

Pyrilutamide's effectiveness is questioned due to overstated claims and previous trial ineffectiveness, with some users opting for finasteride instead. Despite skepticism, some consider adding pyrilutamide to their regimen alongside treatments like bicalutamide.

community Starting Pyrilutimide 5% Update

in Treatment 1 upvotes 2 years ago

The user started using Pyrilutamide 5% for hair loss and has not experienced side effects after two days. They previously had side effects from Fluridil and topical Minoxidil 5%, and their hair continued thinning with topical Spironolactone.

community Source for Pyrilutamide has disappeared

in Treatment 21 upvotes 3 years ago

Anageninc stopping the sale of Pyrilutamide due to a cease and desist order from Kintor, with some speculating that it was either a hoax or subpar product.

community Anyone using Finastopic (no pg Isdin)?

in Product 2 upvotes 2 years ago

The conversation discusses the use of Finastopic, a carrier for finasteride solutions by Isdin, and compares it to a standard propylene glycol (PG) solution. The user was prescribed a 1% finasteride solution using Finastopic and has been using a self-compounded 0.025% topical finasteride with minoxidil.

community Finally about to start Pyriltamide (ONLY Pyriltamide)

in Chat 63 upvotes 1 year ago

A user is excited to start using Pyriltamide for hair loss after experiencing side effects from topical finasteride. Other users discuss the potential and skepticism of Pyriltamide compared to older treatments like finasteride and RU58841.

community Potentially Positive Pyrilutamide News Coming

in Research/Science 6 upvotes 3 months ago

Kintor Pharmaceutical's stock rise suggests potential positive news about Pyrilutamide, a topical anti-androgen. GT20029 may also compete with existing treatments like finasteride and dutasteride.

community Swapping from Fluridil to Pyrilutimide?

in Treatment 1 upvotes 4 months ago

The conversation discusses hair loss treatments, with the main focus on using Fluridil and considering switching to Pyrilutamide. Other treatments mentioned include minoxidil, topical finasteride, nizoral shampoo, and saw palmetto supplements, with advice to stick with Fluridil for at least six months before considering alternatives.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 1 year ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

community What's your thoughts on Pyrilutamide

in Product 5 upvotes 6 months ago

The conversation is about using pyrilutamide and RU58841 as topical solutions to prevent hair loss. Pyrilutamide is considered safer but less potent than RU58841, which some users find effective despite potential side effects like heart palpitations.

community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?

in Product 18 upvotes 3 years ago

An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.