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New hair loss treatments PP405 and VDPHL01 are discussed with skepticism and hope, alongside existing treatments like minoxidil and finasteride. Users express frustration over limited progress since the 1980s but remain cautiously optimistic.

A South Korean company, Therazyne, has developed a promising hair loss treatment using a WNT chain surrogate that binds to Frizzled 7, with human follicle testing expected soon. Current treatments like minoxidil and finasteride are not seen as cures, and while optimism exists for future solutions like PP405, approval processes are lengthy.

Pelage Pharmaceuticals' PP405 aims to treat hair loss by reactivating dormant hair follicle stem cells, showing promising results in early trials. The company plans to present their findings at the American Academy of Dermatology Annual Meeting in 2026.

A 21-year-old experiencing itchy and burning scalp with hair loss was diagnosed with MPB and scalp inflammation. They were prescribed Ketoconazole, Prednisone, Clindamycin, and Finasteride, and are considering trying antihistamines, dietary changes, and "nopoo" to alleviate symptoms.

The user has been using finasteride and minoxidil for hair loss but is experiencing thinning at the crown and is considering a hair transplant. They are seeking advice on other treatments to try before proceeding with a transplant and how to find a reputable doctor.

PP405 is discussed as a potential adjunct therapy for hair loss, with skepticism about its effectiveness and trial results. Users mention combining it with finasteride and minoxidil for better results, while others debate the root causes of hair loss and the limitations of current treatments.

The user is using oral finasteride, oral minoxidil, ketoconazole shampoo, and various supplements to stabilize hair loss and thicken hair. They are considering using minoxidil foam on their beard to address empty patches but are concerned about side effects.

A new topical treatment, PP405, shows promising results for hair regrowth, potentially outperforming existing treatments like finasteride and minoxidil. However, it may still need to be combined with DHT blockers for optimal results, and its long-term effectiveness remains uncertain.

The user is experiencing hair loss despite using oral dutasteride for 7 months and topical minoxidil for 3 months. They are concerned about miniaturization and question if the current minoxidil application is less effective without the previous finasteride mix.

A 26-year-old male experiencing hair loss since 2020 is using topical 5% Minoxidil and 2% Ketoconazole shampoo for four months, still experiencing significant shedding. He is considering cutting his hair short and has not yet started DHT blockers like Finasteride or Dutasteride.

After 7 months of using topical finasteride/minoxidil, microneedling, and Nizoral shampoo, the user believes they are seeing hair regrowth. They are seeking further advice to improve their results, excluding hair transplant options.

The user stopped using finasteride and tried turmeric, ginger, and perilla extract to reduce hair shedding, noticing a significant decrease in hair loss. They experienced side effects like rashes and easy bleeding from perilla extract and softer feet, possibly from turmeric.

A user shared a blog post by "swissTemples" claiming to have reversed hair loss using a combination of treatments including suppressing PGD2 and increasing PGE2. The user noted that "swissTemples" has been banned from forums, possibly due to conflicts of interest.

Finasteride helped stop hair loss progression and slightly thickened hair, but reduced beard and chest hair growth. The user also uses ketoconazole shampoo for scalp itchiness.

A 20-year-old male experienced severe hair loss and scalp issues after using liquid minoxidil, which caused intense itching. Despite trying different treatments like ketoconazole and selenium shampoos, and addressing low vitamin B12 levels, his hair loss and scalp problems persist.

A user in their 30s with male pattern baldness reported significant hair regrowth after starting a daily pill containing 2.5mg Minoxidil and 1mg Finasteride. They were initially skeptical but experienced no side effects and were pleasantly surprised by the results.

The user treated hair loss for one year using low dose topical finasteride, minoxidil, RU58841, ketoconazole shampoo, dermastamping, Botox injections, and supplements. They saw a subtle improvement in their hair loss.

The user shared progress after one year on finasteride, noting slower results without minoxidil and using ketoconazole shampoo for dandruff. Suggestions included adding minoxidil, microneedling, and possibly seeing continued regrowth in the second year.

A 38-year-old man experiencing rapid hair loss plans to try minoxidil and a derma roller, and may consider finasteride if there's no improvement in six months. He seeks advice on genetic hair loss, baseline baldness, dandruff shampoo, and alternative treatments like tea tree oil and rosemary oil.

The user tried non-finasteride treatments for a year with little success, but has seen some improvement in hair thinning after 10 months using topical finasteride/minoxidil. They also use microneedling, Nizoral, rosemary/castor oil treatments, and maintain a nutrient-rich diet.

A user reported that using 0.5 mg finasteride daily, biotin, Nizoral shampoo, and occasional castor oil scalp massages stopped their hair loss after six months. Another user expressed hope for similar results with castor oil.

The conversation is about hair loss and treatments, with suggestions to use finasteride or dutasteride as DHT blockers and minoxidil for regrowth. Oils and shampoos are considered ineffective for androgenic alopecia without these medications.

The user is experiencing diffuse hair thinning despite using dutasteride and minoxidil for over five years and is considering adding oral minoxidil, microneedling, and nizoral to their regimen. They are concerned about the effectiveness and side effects of these treatments, especially with an upcoming event.

The user experienced hair loss improvement using finasteride, minoxidil, Nizoral, and dermastamping over two years, progressing from a diffuse NW3-3.5 to a thicker NW2.5. They advise starting treatment early, enduring shedding phases, and avoiding excessive time on forums.

A 27-year-old male experiencing hair loss at Norwood 3 level has tried minoxidil and finasteride but stopped finasteride due to side effects. He is exploring alternatives like Dermapen, Regenepure DR Shampoo, saw palmetto, and considering aromatase inhibitors for managing side effects, while also seeking advice on DHT blockers.

User noticed receding/thinning hairline, used topical finasteride/minoxidil and scalp scrubber for 4 months, saw progress.

The user has experienced significant hair regrowth using finasteride, oral minoxidil, microneedling, keto shampoo, an LLLT helmet, vitamins, and supplements. They note progress but hope for further improvement in a specific area.

A 19-year-old male with seborrheic dermatitis (SD) experienced significant hair loss and uses keto shampoo, zinc, and Nizoral to manage it. He inquires about the potential for regrowth and whether adding finasteride would help.

Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

A user shares their struggle with hair loss despite trying treatments like finasteride, minoxidil, and dutasteride, and expresses frustration over ineffective medical advice and a failed hair transplant. Others in the conversation suggest alternative treatments, acceptance of baldness, and focusing on other life aspects.