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      community I'm very skeptical about pyrilutamide

      in Product  2 upvotes 2 months ago
      Pyrilutamide's effectiveness is questioned due to overstated claims and previous trial ineffectiveness, with some users opting for finasteride instead. Despite skepticism, some consider adding pyrilutamide to their regimen alongside treatments like bicalutamide.

      community Why is there no feedback on pge2/setipiprant?

      in Question  4 upvotes 9 years ago
      The conversation questions the lack of feedback on the effectiveness of PGE2 and setipiprant for hair loss, despite their availability. The user is puzzled by the absence of reviews or results, whether positive or negative.

      community Do any shampoos contain Piroctone Olamine in the US

      in Product  3 upvotes 1 year ago
      The conversation is about finding shampoos with Piroctone Olamine in the US for itch relief, as the user has not found relief with Keto shampoo, oral Dutasteride, and oral Minoxidil. Users suggest alternatives like Neutrogena T/Gel and online options, but note availability and price issues.

      community M27 Fin/Min (topical) was fun while it lasted

      in Finasteride/Dutasteride  19 upvotes 1 year ago
      The user experienced high liver enzyme levels, possibly due to topical finasteride or supplements, and decided to stop using finasteride while continuing minoxidil. After stopping finasteride and supplements, liver levels returned to normal, suggesting finasteride or supplements might have been the cause.

      community Ketoconazole shampoo for early-stage shedding looks like working!

      in Ketoconazole  33 upvotes 8 months ago
      Ketoconazole shampoo may help with early-stage hair loss by stopping hair regression and promoting new hair growth, though its effectiveness as a DHT blocker is debated. Users report varying results, with some experiencing dryness and others seeing improvement when used 2-3 times a week.

      community ISO a topical without minoxidil

      in Finasteride/Dutasteride  3 upvotes 3 months ago
      A user seeks a topical hair loss treatment without minoxidil, considering options like finasteride, dutasteride, caffeine, tretinoin, or prostaglandin analogues. Recommendations include products like Strut, Maximus, Zeuss, and custom formulas from compounding pharmacies.

      community which is better ; minoxidil with more alcohol or more pg?

      in Minoxidil  4 upvotes 3 years ago
      The conversation is about the effectiveness of Minoxidil formulations with different alcohol and propylene glycol (pg) ratios. The user finds that a formulation with 20% pg and 80% ethanol dries faster but is concerned about absorption time.

      community Which compounds in Saw Palmetto are actually beneficial?

      in Research/Science  2 upvotes 1 year ago
      Saw palmetto's fatty acids, particularly lauric and linoleic acids, inhibit enzymes linked to hair loss, while sterols like beta-sitosterol are less effective due to poor absorption. The conversation questions which specific compounds in saw palmetto contribute to its anti-androgenic effects.

      community Best Hair Regrowth Serum I have ever used

      in Product 1 year ago
      A user shared their positive experience with Musely's Modern Hair Formula and Classic Combo for hair regrowth, highlighting ingredients like IPCs and Exosomes. They offered a $50 gift card for the product, leading to skepticism from others about the promotion.

      community Can I mix minoxidil with Alpecin Caffeine Liquid?

      in Minoxidil 1 year ago
      A user is considering mixing 5% topical minoxidil with Alpecin Caffeine Liquid to enhance its effect, while also using oral finasteride. They seek feedback on potential efficacy loss and downsides of this mixture.

      community CRAZY HIGH? 1% Fin 0.3% GHK-CU topical perscription

      in Treatment  2 upvotes 1 month ago
      The conversation discusses concerns about using a high concentration of 1% topical finasteride for hairline balding, with some users suggesting starting with a lower dose. It also mentions the use of GHK-CU peptide and the importance of considering the formulation to avoid excessive absorption.

      community Found a slide summary for PP405

      in Research/Science  36 upvotes 3 weeks ago
      PP405 shows promise in stimulating new terminal hair growth by activating dormant follicles, with no systemic adverse effects observed in a short-term trial. However, long-term efficacy remains unproven, and further trials are needed to confirm its potential as a hair loss treatment.

      community RU58841 vehicle penetration (Study for minoxidil)

      in Treatment  11 upvotes 2 years ago
      The user mixes their own RU58841 solution and found that increasing the ethanol content improved absorption and reduced scalp itching. A study on minoxidil showed that penetration increased with higher ethanol concentrations, reaching maximum penetration at 90% ethanol.

      community Update progress on Fin, Min, and Kx-826

      in Is this regrowth?  7 upvotes 1 year ago
      The user is using oral finasteride, minoxidil, and KX-826 for hair regrowth, noticing small improvements. They plan to add ketoconazole shampoo and consider a hair transplant with verteporfin after a year of treatment.

      community Having Ru58841 mailed to my house

      in Research/Science  1 upvotes 2 months ago
      RU58841 can be ordered as a powder and compounded at home, but it should be stored at room temperature to avoid crystallization. Pyraulatmide may follow a similar principle.

      community Blood DHT Levels – before and after creatine

      in Research/Science  41 upvotes 3 years ago
      The impact of creatine on DHT levels, and whether it could cause accelerated male pattern baldness (MPB). The user taking a 5 alpha reductase inhibitor found that their DHT levels actually reduced despite taking creatine for nine weeks. Replies suggested looking into testosterone levels as well and debating the safety of creatine use in relation to MPB.