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      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 8 months ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

      community Kintor long term safety phase 3

      in Research/Science  66 upvotes 1 year ago
      Kintor's phase III trial for pyri (KX-826) showed promising safety and efficacy results, with no drug-related sexual dysfunction reported. Users discussed their experiences with pyri, Minoxidil, Dutasteride, and concerns about the validity of the study results.

      community Choose your topical antiandrogen and tell me why

      in Product  6 upvotes 1 year ago
      The conversation is about choosing a topical antiandrogen for hair loss, with options including RU58841, CB0301, Pyrolutamide, Alfatradiol, and Fluridil. Users discuss their preferences and reasons for selecting specific treatments.

      community Terrible experience with MV Supplements and no support

      in Product  3 upvotes 1 year ago
      A user had a bad experience with MV Supplements when their Pyril powder and ethanol order leaked during shipping, making the products unusable. Despite contacting support and providing evidence, the company's return policy did not allow for a refund or replacement.

      community Finasteride not working isnt it MPB?

      in Finasteride/Dutasteride  5 upvotes 1 year ago
      A user is concerned that finasteride isn't working for their hair loss, questioning if it's due to male pattern baldness or low iron levels. They are advised to take finasteride daily and get blood work done.

      community Reminder how little the average person knows about hair loss

      in Satire  642 upvotes 3 years ago
      How little the average person knows about hair loss and how it can be an unfairly stigmatized issue, even by people with little knowledge of it themselves. Some specific treatments that were discussed include finasteride, RU58841, dutasteride, minoxidil, pyritinol, dermarolling, and diet/lifestyle changes.

      community Do not use oral dutasteride from Strut Health.

      in Finasteride/Dutasteride  29 upvotes 3 years ago
      The ineffectiveness of Strut Health's dutasteride capsules, which are filled with raw powder instead of liquid and don't contain any buffering agents that would allow for absorption into the bloodstream. It is suggested to use other brands of liquid-filled dutasteride capsules for better results.

      community How do you use rosemary oil and peppermint oil?

      in Question  7 upvotes 6 years ago
      Rosemary oil and peppermint oil may promote hair growth and increase cutaneous blood flow, showing promise as treatments for androgenetic alopecia. Minoxidil 2% is also used for treating hair loss.

      community Trinov seems to be working.

       20 upvotes 7 years ago
      Minoxidil initially worked but then failed. Trinov has significantly reduced shedding and shows promising results.

      community My hair journey: 2017 through the present

      in Progress Pictures  511 upvotes 1 year ago
      A user shared their hair loss journey from 2017 to 2024, detailing the use of finasteride, minoxidil, dutasteride, supplements, and dermarolling. They experienced significant hair loss after stopping finasteride in 2017, saw some regrowth after resuming treatments in 2023, and are considering a hair transplant.

      community 18M 8 months progress 40mg daily dut stack

      in Progress Pictures  112 upvotes 11 months ago
      An 18-year-old is using a high-dose hair loss treatment with 40mg daily dutasteride, finasteride, minoxidil, tretinoin, and topical bicalutamide. Despite health risk concerns, especially liver issues, they report hair regrowth progress and intend to continue the regimen.

      community 4 month Finasteride and 3 month Minoxidil Results

      in Finasteride/Dutasteride  1400 upvotes 5 years ago
      A user's success in treating his diffuse and crown hair loss with finasteride and minoxidil; other users sharing their experiences, both successful and unsuccessful, and the importance of research and listening to one's body when deciding on treatments.

      community Is PP405 gonna flop or what???

      in Research/Science 2 weeks ago
      PP405 is viewed skeptically, with some seeing it as overhyped and potentially ineffective compared to existing treatments like minoxidil and finasteride. While it shows some promise in activating dormant hair follicles, many believe it won't replace hair transplants or significantly outperform current options.

      community A Short Recap on PP405 and AAD 2026

      in Update 3 weeks ago
      PP405 is a promising experimental topical treatment for alopecia that reactivates dormant hair follicles by targeting cellular energy, with large-scale trials planned for 2026. While it shows potential, it cannot regenerate permanently destroyed follicles, making hair transplants the only guaranteed solution for advanced baldness currently.

      community Pelage are starting phase 3 for PP405 towards the end of 2026

      in Chat  180 upvotes 2 months ago
      PP405 is moving to late-stage trials, showing potential for hair regrowth, with 31% of male patients experiencing a 20% increase in hair density. Veradermics is developing an oral minoxidil version, and there is interest in combining treatments for better results.

      community 1 year on finasteride + minoxidil

      in Progress Pictures  133 upvotes 2 months ago
      A 22-year-old has been using 1mg oral finasteride and 5mg oral minoxidil for a year, considering switching to dutasteride due to perceived lack of results. Most responses suggest continuing the current treatment as hair quality has improved, with some recommending against switching to dutasteride and suggesting alternatives like dermarolling or hair transplants for hairline issues.

      community Don’t do like me. Don’t take a long break from Fin and Min

      in Chat  124 upvotes 5 months ago
      Stopping finasteride and minoxidil can cause significant hair shedding, so they should be continued indefinitely. Concerns about finasteride affecting fertility or causing birth defects are mostly unfounded, but some stop for personal reasons.

      community How far back can Dutasteride regrow losses?

      in Finasteride/Dutasteride  43 upvotes 5 months ago
      Dutasteride can regrow hair lost up to 10 years ago for some, especially when combined with minoxidil, but results vary widely. Some users report significant regrowth, while others see no change or only maintain existing hair.

      community Accelerated Hair Loss from Creatine

      in Finasteride/Dutasteride  134 upvotes 5 months ago
      Creatine may cause hair loss in some individuals, especially those on finasteride, despite no scientific link. Personal experiences suggest individual sensitivity to DHT could be a factor.
      21M on Minoxidil 3 Months: Should I Add Finasteride for Thinning Hair?

      community 21M on Minoxidil 3 Months: Should I Add Finasteride for Thinning Hair?

      in General  246 upvotes 5 months ago
      A 21-year-old male experiencing hair thinning started using Minoxidil, which stopped his shedding and led to the growth of vellus hairs on his temples. He is considering whether to add finasteride to his routine, which currently includes Minoxidil, derma rolling, ketoconazole shampoo, vitamin D3, zinc, and a rosemary and fenugreek lotion.

      community Can we get a reality check on PP405?

      in Research/Science  81 upvotes 6 months ago
      PP405 is a promising hair loss treatment that may outperform minoxidil and finasteride by reviving dormant follicles and promoting significant regrowth. Results from ongoing trials are awaited, with a potential market release between 2028-2030.