PP405 is discussed as a potential hair loss treatment, but its effectiveness and safety are uncertain. Some users express skepticism, while others are hopeful, comparing it to existing treatments like Minoxidil and Finasteride.
Bryan Johnson uses Dutasteride, Latanoprost, Minoxidil with Tretinoin, and other unproven treatments, while Derek uses Finasteride, Minoxidil, Nizoral, RU58841, and Castor Oil. Kevin uses Finasteride, Minoxidil, RU58841, and Alfatradiol, but is against Nizoral and microneedling, preferring Tretinoin for absorption.
Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.
The user experienced significant hair regrowth after 4 months using oral minoxidil, oral dutasteride, topical minoxidil, Nizoral shampoo, microneedling, and various supplements. They reported increased body hair and some acne as side effects but noticed less hair breakage with silk pillows.
Bryan Johnson's new hair loss product, which includes peptides, is viewed skeptically by many, with concerns it may be a money grab rather than an effective treatment. Most users prefer proven treatments like finasteride and minoxidil, which are cheaper and have established results.
A 26-year-old male is considering starting the "Big 3" treatments for hair thinning, which include Minoxidil, finasteride, and RU58841, and is unsure whether to begin these treatments or consult a dermatologist first.
A 25-year-old male shared his one-year hair loss progress using oral finasteride, oral minoxidil, and weekly ketoconazole, noting stabilized hair loss but no recent improvement. He is considering a hair transplant and possibly PRP sessions, while planning to continue medication.
PP405 is a new hair loss treatment facing mixed reactions due to initial hype and insufficient data. Some are hopeful, but many doubt its effectiveness compared to minoxidil and finasteride.
A user shared their positive experience with hair regrowth after three months using topical minoxidil twice daily, 1mg finasteride every morning, and microneedling every 10 days. They reported no side effects and encouraged others to consider similar treatments.
The conversation discusses alternatives to minoxidil for hair loss, with suggestions including aminexil, redensyl, stemoxydyne, and topical cetirizine. Users share mixed results with these alternatives and emphasize combining treatments with dermarolling, diet, and exercise.
The user experienced significant hair regrowth using oral finasteride (1 mg) and oral minoxidil (2.5 mg) daily, with minimal side effects. They also use testosterone to balance any libido effects from finasteride.
A 17-year-old is experiencing hair thinning and is using minoxidil, ketoconazole shampoo, saw palmetto, and pumpkin seed oil. They are considering starting finasteride but are concerned about its effects on development and are seeking advice on whether to proceed with finasteride or switch to oral minoxidil.
The user experienced significant hair regrowth using 1 mg of finasteride daily for 1.5 years, without needing minoxidil. The regrowth was surprising, especially in the hairline, and some users speculated about a possible hair transplant.
The user is considering starting dutasteride (DUT) 0.5mg for hair loss due to lack of access to finasteride and is concerned about potential side effects. They seek guidance on whether to begin this treatment.
France is considering reviewing finasteride and dutasteride due to concerns about their safety, but a ban in the EU is unlikely due to regulatory hurdles. Many users express frustration over the potential ban, emphasizing the effectiveness of finasteride for hair loss and criticizing the influence of anecdotal evidence on public health policy.
Minoxidil requires at least 6 months to show results and may not work for everyone. Combining it with Finasteride can improve outcomes, but stopping Minoxidil can result in losing any regrowth.
A 24-year-old male doctor shares his 3-month progress using 0.5 mg oral finasteride and 5% topical minoxidil daily, noting some hair regrowth and incorporating microneedling. He prefers a "less is more" approach initially and discusses the potential benefits of oral minoxidil.
The conversation discusses the potential of PP405 as a hair loss treatment, with some users expressing skepticism and others hopeful about its development. There is also mention of other treatments like Minoxidil, Finasteride, and Pyrilutamide, with users debating the effectiveness and safety of self-experimentation versus waiting for clinical trial results.
Finasteride can cause dry eyes and vision issues due to its impact on the meibomian glands. Users have mixed experiences, with some experiencing eye discomfort and others having no side effects.
PP405 is a potential hair loss treatment that may reactivate dormant hair follicles, with Phase 3 trials expected. Some users are cautious, suggesting using finasteride in the meantime, while others are skeptical about PP405's effectiveness.
A 15-year-old is experiencing hair loss and has tried rosemary and jojoba oils without success. They are advised to see a doctor for thyroid and androgen tests and consider using Minoxidil.
Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.
Finasteride and Dutasteride are under review in the EU due to concerns about side effects like depression, but they are unlikely to be banned. Access to these medications varies, with easier availability in the UK compared to some EU countries.
The user switched from Finasteride to Dutasteride due to continued hair loss, using Dutasteride twice a week while continuing Finasteride on other days, and also using Minoxidil and Ketoconazole shampoo. They are considering increasing Dutasteride dosage and are uncertain about continuing Minoxidil due to lack of visible results.
Hair loss can be managed by acting early, using treatments like Minoxidil, finasteride, and possibly dutasteride, along with lifestyle changes such as using sulfate-free shampoos and eating protein-rich foods. Consulting a dermatologist and considering microneedling, vitamins, and anti-fungal shampoos are also recommended.
The conversation discusses hair regrowth progress using finasteride, minoxidil, and vitamin D, with some users experiencing shedding and others seeing improvement. Additional treatments like dutasteride, topical solutions, and lifestyle changes are also mentioned.
The user experienced hair loss since 2019 and tried finasteride, dutasteride, RU58841, and ketoconazole shampoo without success. A scalp biopsy showed scarring and inflammation from folliculitis, indicating chronic inflammation was affecting treatment effectiveness.
A husband saw significant hair regrowth in 2.5 months using minoxidil, finasteride, collagen, biotin, multivitamins, GHK-cu, microneedling, and scalp oils. His wife highlighted the routine's effectiveness and the importance of consistency.
To minimize hair loss while using steroids, use finasteride or dutasteride and apply topical anti-androgens like RU58841. Avoid high doses of hair-toxic steroids; prefer testosterone, nandrolone, and boldenone.