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      community Solo use of Pyrilutamide: UPDATE

      in Update  45 upvotes 3 years ago
      A user who has been using Pyrilutamide for 19 days, experiencing some hair thickening in the right temple and crown area but also having ball ache after microneedling; other users offer advice, caution and skepticism as to whether results can be seen in such a short time.

      community RU58841 Users: How chemically unstable is RU58841 in practice?

      in Technology  2 upvotes 7 months ago
      The conversation discusses using RU58841 mixed with topical minoxidil for hair loss, noting its chemical instability and storage challenges. A user shares their experience using RU58841 with ethanol and propylene glycol, mentioning no significant results yet.

      community Wrap it up everyone. CB-03-01 is another failed treatment

      in Treatment  82 upvotes 7 months ago
      CB-03-01 is considered a failed treatment for hair loss, with future hopes pinned on PP-405 and GT-20029, expected by 2030. Alternatives like hair transplants and SMP are discussed, while some users express frustration over the slow progress of treatments like Breezula.

      community Exosome Therapy feedback needed

      in Microneedling  4 upvotes 5 months ago
      Exosome Therapy for hair loss, including its results and cost. The discussion also touches on the various serums used in this therapy.

      community Interpreting pre-finisteride blood panels

      in Chat  2 upvotes 10 months ago
      The conversation is about someone planning to start finasteride for hair loss and wanting to interpret pre-treatment blood panels to assess the risk of side effects like gynecomastia. They list various tests to measure hormone levels and other health indicators.

      community RU58841 KB Solution vs PG + Ethanol

      in Research/Science  7 upvotes 2 years ago
      The conversation discusses the differences between KB solution and PG + Ethanol solution for RU58841 in treating hair loss. It compares the effectiveness and properties of these two solutions.

      community Blood Test Recommendations & Brewers Yeast

      in Treatment  3 upvotes 1 year ago
      The user is considering blood tests to understand their receding hairline and is exploring brewer's yeast for its biotin content. They have been using topical Minoxidil, biotin, collagen, and microneedling, but are avoiding oral Finasteride and Dutasteride.

      community Anyone who used RU58841 without fin/dut?

      in Product  1 upvotes 1 year ago
      RU58841 was used by some for hair loss, but concerns about side effects like gynecomastia and safety were raised. Alternatives like finasteride, minoxidil, pyrilutamide, and alfatradiol were discussed, with some users reporting better experiences with these treatments.

      community How likely do you think it is for PP405 to come out?

      in Research/Science  21 upvotes 6 months ago
      PP405 is a potential new hair loss treatment that works through metabolic pathways rather than hormonal ones, with an estimated market release between late 2027 and 2029. Current alternatives to finasteride include minoxidil, pyralutamide, fluridil, and RU58841, with hair transplants also being a viable option.

      community I got a weird one you guys/gals

      in Chat  10 upvotes 1 year ago
      A 33-year-old man experienced diffuse thinning and hair shedding due to sleep deprivation and low testosterone. After starting hCG treatment, he noticed hair regrowth on his temples.

      community The expected timeline for PP405 - Next update at AAD Annual Meeting in March 2026 ?

      in Treatment  30 upvotes 3 months ago
      A new hair loss treatment, PP405, showed promising Phase 2a results with 31% of patients experiencing over 20% hair density increase without systemic absorption, avoiding hormonal side effects. The treatment is expected to be expensive, with Phase 3 trials starting mid-2026, and there is skepticism about the data's strength.

      community HLT Megathread on HMI-115 (key takeaways in comments)

      in Research/Science  39 upvotes 3 years ago
      HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.

      community Fuzzy hair growth with procapil??

      in Is this regrowth?  5 upvotes 7 months ago
      The user experienced temporary peach fuzz growth using a product with procapil and later tried minoxidil and finasteride without significant results. Their boyfriend has used minoxidil and finasteride consistently for over five years with sparse hair improvement.

      community Today was Last update on pp405

      in Research/Science  109 upvotes 9 months ago
      A new hair loss treatment, PP405, is moving from phase 2A to 2B in clinical trials, sparking discussions about its potential to regrow dormant hairs and its impact on existing treatments like Minoxidil and finasteride. Some users express skepticism, while others are hopeful about its future effectiveness.

      community Cure/better treatment options in the future

      in Chat  11 upvotes 1 year ago
      The conversation is about future hair loss treatments. Current treatments mentioned include finasteride, minoxidil, and RU58841, with potential future treatments like GT20029, TDM-105795, JW0061, and follicle cloning.

      community currently active protocols, working so far

      in Update 3 years ago
      The conversation is about a person's hair loss treatment routine, which includes Metformin, sleep in darkness, avoiding EMF at night, Nizoral, Dermarolling, Castor oil, and Collagen. They have observed less hair shedding and increased hair volume.

      community KX-826 1% Phase II Results from China Just Dropped

      in Research/Science  37 upvotes 8 months ago
      KX-826 (Pyrilutamide) 0.5% and 1.0% solutions showed promising results in increasing hair count for male androgenetic alopecia, with the 0.5% dose slightly outperforming the 1% dose. The treatment was well-tolerated with no sexual side effects, but skepticism remains due to past inconsistencies in trial results.

      community Chat is this real? Compound called clascoterone

      in Research/Science  588 upvotes 4 months ago
      Clascoterone shows promising results for hair regrowth in men with androgenetic alopecia, with potential FDA approval by 2026. It acts as a topical androgen receptor blocker, offering a new treatment option with minimal side effects compared to existing treatments like finasteride.

      community I think Ru58841 stopped my itching.

      in Chat  4 upvotes 1 year ago
      RU58841 stopped scalp itching for the user, providing relief from persistent itchiness associated with hair loss. Some users reported side effects like chest pain, while others found relief with different treatments like mometasone.

      community Anyone looking at peptides for hair?

      in Treatment  9 upvotes 2 months ago
      The conversation discusses interest in peptides for hair loss, specifically mentioning ahkCU and ghkCU. A user is considering adding ghkCU to their treatment regimen.