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GlossaryPohl-Pinkus constrictions

narrow, weakened areas on hair shafts from growth disruptions

Pohl-Pinkus constrictions are narrow, weakened areas along the hair shaft that can occur due to temporary disruptions in hair growth, often caused by physical or emotional stress, illness, or nutritional deficiencies. These constrictions can make the hair more prone to breakage and are sometimes used as indicators of past physiological stress in trichological examinations.

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community A warning to anyone considering 3rd party sourcing PP405 or its analogs

in Treatment 31 upvotes 2 months ago

Be cautious when sourcing PP405 or its analogs from third-party suppliers due to potential safety risks and lack of regulatory approval. The conversation highlights concerns about counterfeit products and the absence of reliable testing, making it risky to use such treatments.

community Is anyone taking both boron and p5p to lower SHBG and Prolactin respectively? What are you experience on this?

in Update 5 upvotes 3 years ago

The user is applying topical finasteride with stemoxydine for hair loss and has noticed hair thickening but no regrowth after two months. They also report high SHBG and prolactin levels and a lack of morning erections, even on low doses of medication.

community PG causing irritation when applying RU

in Research/Science 2 years ago

The user is experiencing irritation from using PG with RU58841 and is seeking alternative solutions like K&B in the UK. They report redness, itchiness, and flaky skin from the current treatment.

community Pelage have presented only phase 2a. The rest of phase 2 for PP405 will be presented at a later medical meeting

in Chat 30 upvotes 2 months ago

PP405's phase 2a trial results were presented, focusing on safety and pharmacokinetics, with a future meeting planned to share the full dataset. The trial includes a randomized controlled portion and an open-label extension, with no indication of phase 2B completion.

community Pp405 phase 2a clinical results

in Research/Science 40 upvotes 11 months ago

PP405 shows initial promise for treating androgenetic alopecia, with safety confirmed in early trials, but skepticism remains due to limited data. Further trials are needed to determine its true efficacy and potential market impact.

community Will pp405 have to be inserted rectally for full benefits?

in Transgender 31 upvotes 6 months ago

Pp405 is discussed as a potential hair loss treatment, with humorous suggestions about rectal administration for increased effectiveness. Users joke about unconventional methods and express willingness to try anything for hair regrowth.

community Phase 2B trial for PP405 leaked (The study Pelage DOESN'T want you to see)

in Research/Science 2 months ago

The conversation discusses hair loss treatments, mentioning minoxidil, finasteride, RU58841, VDPHL, GT20029, and follicle cloning as potential solutions. It also reveals that the discussion about PP405 was an April Fool's joke.

community PP405 (Non) Update - Feb 2025

in Research/Science 34 upvotes 1 year ago

The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

community How long are Pelage going to milk the phase 2a results of PP405?

in Chat 21 upvotes 4 months ago

PP405, a potential hair loss treatment, is facing delays in releasing Phase 2 results, causing frustration among users who compare it to past failed treatments. Despite skepticism, some remain hopeful about PP405's future, while others discuss alternative treatments like Clascoterone and its expected market release.

community Why doesn't phase 3 of PP405 start straight away?

in Chat 14 upvotes 5 months ago

Pelage is delaying the start of phase 3 trials for PP405 to 2026 due to necessary regulatory processes, despite having $120 million in funding. Users discuss the potential of PP405 for hair regrowth, with some expressing skepticism and others hopeful for new treatments like Breezula.

community DLQ01: A Better "Minoxidil" PGF2a synthetic analogue.

in Research/Science 3 upvotes 1 year ago

DLQ01, a prostaglandin F2α analog, shows promise for hair growth by directly stimulating PGE2/PGF receptors without needing conversion, and can be combined with minoxidil and retinoids like tretinoin for enhanced effectiveness. Minoxidil's efficacy may be reduced by COX-1 inhibitors, but using prostaglandin analogs like Latanoprost or Bimatoprost can help maintain its effectiveness.

community Federal Grant Cuts have impacted PP405 related research

in Technology 460 upvotes 9 months ago

Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.

community Apparently you can try PP405 right now!?

in Research/Science 33 upvotes 1 year ago

PP405 is likely a scam, with concerns about its legitimacy and safety, as it may cause unintended tissue growth. Users suggest sticking to known treatments like finasteride and minoxidil.

community PP405 2a study was a safety study. Some rational explaining.

in Research/Science 22 upvotes 9 months ago

The conversation discusses the safety study of PP405, emphasizing that early trials focus on safety rather than efficacy, and that any efficacy data from such a short study should be viewed skeptically. It also highlights that the information released is primarily for securing funding, and that meaningful efficacy results are expected in later phases.

community Don't use PP405 from everychem. it is likely fake.

in Research/Science 66 upvotes 11 months ago

PP405 from Everychem is likely fake and potentially harmful, with concerns about its stability and the risk of using the wrong MPC inhibitor, which could damage hair follicles. The real PP405 was studied under strict conditions, and DIY attempts are discouraged due to unknown formulation and quality control.

community How many years can we expect PP405 to be on the market

in Product 12 upvotes 10 months ago

PP405 is expected to be on the market between 2027 and 2030, with phase 3 trials starting in 2026. There is skepticism about its fast-tracking due to its cosmetic nature, and it may appear on the gray market sooner.

community Approve PP405 quickly you coward

in Satire 193 upvotes 11 months ago

Pelage Pharmaceuticals is developing PP405, a topical treatment for hair growth, currently in Phase 2a trials. There is skepticism about the company's claims, and no fast-tracking approval timeline has been detailed.

community Full extent of pp405 effectiveness

in Treatment 14 upvotes 7 months ago

The conversation discusses the potential effectiveness and future results of the hair loss treatment pp405, with questions about its impact on different hair loss stages and areas. There is anticipation for phase 3 trial results to provide more data, and hope that pp405 could enhance hair transplant outcomes.

community If inhibiting DHT can cause Prolactin to increase then is the opposite also true?

in Treatment 5 upvotes 2 years ago

The conversation discusses using P5P (Vitamin B6) supplements to reduce elevated Prolactin levels and concerns about its potential effect on increasing DHT levels. The user is not currently using finasteride or any anti-androgens.

community PELAGE PHASE 2 TRIALS FOR PP405 - Volunteers Needed

in Research/Science 25 upvotes 1 year ago

PP405 is a topical gel being tested for hair regrowth in adults with androgenetic alopecia. Volunteers aged 18-55 are needed for a 16-week trial in several US locations.

community P-1075: a BETTER version of Minoxidil

in Research/Science 7 months ago

P-1075 is a more potent hair growth agent than Minoxidil, but it poses significant heart risks, making it unsafe for use. Despite promising results in macaques, concerns about its cardiotoxicity in rats have halted its development.

community Ru58841 and pyrilutamid receptor binding affinity vs spironolactone?

in Female 6 upvotes 3 years ago

Female considering adding topical anti-androgen, seeks advice on RU58841 or pyrilutamid's binding affinity compared to spironolactone.

community The story of RU58841/PSK3841

in Research/Science 1 year ago

RU58841, an anti-androgenic compound, showed early promise for treating alopecia but faced challenges after its patent in 1997. Despite advancing to Phase II trials, safety concerns and financial struggles led Aventis to abandon its development. Proskelia, which later merged into ProStrakan, couldn't prioritize the drug, leading to its eventual stagnation and failure to reach the market.

community My summation of PP405 - looks promising

in Research/Science 206 upvotes 1 year ago

PP405 shows promise for hair regrowth by manipulating stem cell characteristics and lactate dehydrogenase, with Phase 2a trials pending. Google Ventures' $15M investment suggests confidence, but results and market availability remain uncertain.

community PP405 is nothing but a scam and Pelage know it.

in Chat 78 upvotes 9 months ago

PP405 is criticized for overhyped claims and cherry-picked data, with doubts about its effectiveness compared to minoxidil and finasteride. Many users express skepticism, emphasizing the need for more comprehensive trial results.

community Pp405 any site for buying in Europe

in Product 1 month ago

PP405 is not commercially available or legitimate in Europe. Users are discussing the lack of availability of this product.

community Petition Alert: Let's Get PP405 Phase 3 Trials in Germany by 2026!

in Research/Science 57 upvotes 11 months ago

A user is advocating for Phase 3 trials of the hair loss treatment PP405 to be conducted in Germany, citing benefits like a diverse patient base and faster access for European patients. Despite skepticism about the petition's influence, the user believes it can demonstrate significant interest and potentially influence strategic decisions.

community I have Post PP405 Syndrome(PPS). Should I start a foundation?

in Satire 33 upvotes 11 months ago

The conversation humorously discusses the fictional "Post PP405 Syndrome" and the idea of starting a foundation or cult around it. It mentions skepticism about the effectiveness of PP405 and jokes about future therapies.

community Does This Invalidate PP405 Completely?

in Research/Science 3 months ago

PP405's effectiveness in increasing hair density is questioned due to a small sample size, despite investment from Google Ventures. Users express skepticism and suggest waiting for more conclusive results.

community Pelage PP405 Phase 2a completed.

in Research/Science 61 upvotes 4 months ago

Minoxidil, finasteride, and RU58841 are discussed as treatments for hair loss, with excitement around a new drug, PP405, and a reformulated oral minoxidil in trials. Concerns about cost, side effects, and long-term use are also mentioned.