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GlossaryPohl-Pinkus constrictions

narrow, weakened areas on hair shafts from growth disruptions

Pohl-Pinkus constrictions are narrow, weakened areas along the hair shaft that can occur due to temporary disruptions in hair growth, often caused by physical or emotional stress, illness, or nutritional deficiencies. These constrictions can make the hair more prone to breakage and are sometimes used as indicators of past physiological stress in trichological examinations.

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community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 4 months ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community Haircafe slams pp405 presentation. Are results really that bad?

in Treatment 65 upvotes 2 months ago

PP405 shows promise in activating dormant hair follicles and increasing hair counts but lacks detailed efficacy data compared to minoxidil and finasteride. Opinions are mixed, with some optimism and skepticism about its effectiveness.

community Track hairline of Pelage executives

in Research/Science 38 upvotes 8 months ago

Pelage executives' hairlines were discussed, with speculation about them using PP405 for hair regrowth. Concerns were raised about using untested drugs, with some suggesting executives might not risk using them without safety data.

community Welp - pp405 conference showed nothing

in Update 77 upvotes 2 months ago

PP405 shows potential for hair growth by increasing terminal hair and converting vellus hairs, but results are modest and more waiting is needed. It complements existing treatments like minoxidil and finasteride, but won't replace them.

community PP405 Identity Research

in Research 292 upvotes 10 months ago

PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

community Pp405 - it has to work. It has to.

in Research/Science 170 upvotes 3 months ago

Hair loss treatments, including PP405, minoxidil, finasteride, and RU58841, with hopes for future solutions. Participants discuss the emotional impact of hair loss and consider alternatives like hair transplants or acceptance.

community PP405 vs Hair Cloning – Which Would Be Better for NW7 to NW1?

in Research/Science 18 upvotes 9 months ago

PP405 and hair cloning are discussed as potential treatments for reversing hair loss from Norwood 7 to Norwood 1. Hair cloning is seen as a more permanent solution, while PP405's effectiveness and long-term effects remain uncertain.

community Does This Invalidate PP405 Completely?

in Research/Science 3 months ago

PP405's effectiveness in increasing hair density is questioned due to a small sample size, despite investment from Google Ventures. Users express skepticism and suggest waiting for more conclusive results.

community PP405 mechanism question - looking for discussion

in Treatment 6 upvotes 2 months ago

PP405 may promote short-term hair growth by pushing follicles into the growth phase, but concerns exist about long-term effects due to lack of rest phases. Users discuss various treatments like finasteride, minoxidil, spironolactone, alfatradiol, and investigational drugs like KX-826 and GT20029 for hair maintenance and regrowth.

community Update on PP405 Trails - Pelage

in Research/Science 14 upvotes 4 months ago

The conversation discusses interest in participating in PP405 trials for hair loss treatment, with users expressing uncertainty about eligibility due to location. Participants are eager for updates and willing to pay for shipping if trials are limited to America.

community PP405 Hair Loss Drug: Phase 1 Human Results & Biopsy Insights

in Research/Science 215 upvotes 1 year ago

PP405 is a potential hair loss treatment undergoing trials, with discussions on its effectiveness and comparison to existing treatments like finasteride and minoxidil. There is skepticism about its status as a cure, with hopes for future advancements in genetic treatments like CRISPR.

community Found a slide summary for PP405

in Research/Science 33 upvotes 2 months ago

PP405 shows promise in stimulating new terminal hair growth by activating dormant follicles, with no systemic adverse effects observed in a short-term trial. However, long-term efficacy remains unproven, and further trials are needed to confirm its potential as a hair loss treatment.

community Published in Nature: Osteopontin, a protein involved in the growth of hair on moles could be the key to our troubles.

in Research/Science 12 upvotes 2 years ago

Osteopontin, a protein involved in hair growth on moles, may help with hair loss. However, it is also linked to Alzheimer's, cancer, and bone development, so caution is advised.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

in Research/Science 145 upvotes 3 months ago

Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.

community New article on PP405..........

in Research/Science 109 upvotes 1 year ago

Scientists at UCLA have developed a promising treatment for male pattern baldness using a molecule called PP405, which can potentially stimulate dormant hair follicles. Initial trials showed significant results within a week, but larger clinical trials are needed to confirm its efficacy and safety.

community Pelage are still talking about phase 2a results of PP405

in Chat 13 upvotes 2 months ago

PP405 shows promise for hair regrowth, with new hairs observed in 66% of patients in just 27 days. The discussion also mentions Minoxidil, finasteride, and RU58841 as potential treatments.

community Hair Multiplication Photos from Koehler Lab at Harvard

in Research/Science 17 upvotes 6 months ago

The conversation discusses hair loss treatments, specifically mentioning Minoxidil, finasteride, and RU58841, and highlights hair multiplication research from Koehler Lab at Harvard. Users express optimism about future advancements.

community Pelage, PP405, is creating a database for potential new trial volunteers

in Research/Science 148 upvotes 8 months ago

PP405 is a new hair loss treatment targeting dormant hair follicles, with ongoing trials. Some users consider stopping finasteride and minoxidil to join trials, while others doubt its effectiveness.

community Pelage Announces Positive Results of Phase 2a Trials for PP405

in Update 300 upvotes 1 year ago

PP405 shows promise in treating severe hair loss, with 31% of users experiencing over 20% hair density increase in four weeks, faster than minoxidil and finasteride. Some users are skeptical about the results' significance and long-term efficacy.

community I want to sacrifice my hair in the name of science

in Chat 12 upvotes 2 years ago

The conversation discusses various theories of hair loss, including DHT sensitivity and genetic factors, with the user willing to use themselves for research due to having a hair loss gene but different hair loss patterns compared to their brothers. Specific treatments were not mentioned in the provided text.

community Full extent of pp405 effectiveness

in Treatment 14 upvotes 8 months ago

The conversation discusses the potential effectiveness and future results of the hair loss treatment pp405, with questions about its impact on different hair loss stages and areas. There is anticipation for phase 3 trial results to provide more data, and hope that pp405 could enhance hair transplant outcomes.

community Anyone here have a lot of knowledge on hair follicle stem cells and progenitor cells for PP405?

in Chat 4 upvotes 5 months ago

Hair follicle stem cells remain in bald individuals, but progenitor cells do not, raising questions about hair regrowth claims by Pelage. PP405 is discussed as a potential treatment, with skepticism about its effectiveness compared to existing treatments like Minoxidil and Finasteride.

community Since there is so much hype for cosmeRNA and HMI-115...

in Chat 44 upvotes 3 years ago

Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

community Federal Grant Cuts have impacted PP405 related research

in Technology 460 upvotes 9 months ago

Federal funding cuts have delayed PP405 research, affecting hair loss treatment progress, though clinical trials will continue. The discussion highlights PP405's potential compared to minoxidil and finasteride and stresses the importance of government-funded research.

community The Worst Hair Loss Condition You (MAY) have: LPP

in Research/Science 50 upvotes 1 year ago

Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

community PP405 - hair stem cell stimulation

in Research/Science 53 upvotes 2 years ago

PP405, a topical LDH inhibitor, has shown to stimulate hair follicle stem cell proliferation in humans with moderate hair loss. They are advancing to more detailed trials this year.

community Rhamnose-Mediated Modulation of Hair Follicle Growth: Insights from Chemical Genomics

in Research 47 upvotes 1 year ago

Rhamnose may promote hair growth and pigmentation, suggesting it as a potential hair loss treatment. The conversation discusses its potential alongside known treatments like Minoxidil, finasteride, and RU58841.

community Pelage PP405: New Hair Growth from Inactive Follicular Units - Phase 2a results at AAD 2026

in Research/Science 1067 upvotes 2 months ago

PP405, a topical treatment, shows promise for hair growth by activating inactive follicles, with 66% of participants experiencing positive results. The treatment is well-tolerated and may proceed directly to Phase 3 trials, offering a potential alternative to minoxidil and finasteride.

community Han Bio claims success at Hair Multiplication

in Research/Science 20 upvotes 5 years ago

Han Bio claims success in hair multiplication using dermal papilla cells. Treatments discussed include Minoxidil, finasteride, and RU58841.

community You will lose hair if your prostaglandins aren't in balance

in Research/Science 56 upvotes 1 year ago

Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.