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      community Cmon Pyrilutamide and CosmeRNA 😭

      in Chat  34 upvotes 3 years ago
      Users discuss waiting for new hair loss treatments and share struggles with side effects from current options like Minoxidil and Finasteride. They express hope for Pyrilutamide and CosmeRNA to provide better solutions.

      community Does anyone know of the actual effectiveness of the DP2 inhibitors?

      in Question  4 upvotes 8 years ago
      Setipiprant and Fevipiprant are questioned for their effectiveness in hair maintenance, with skepticism due to lack of convincing results beyond vellus hair growth. The user is satisfied with Minoxidil and Finasteride but is curious about the potential of DP2 inhibitors.

      community Anyone in the discord server for pp405 research?

      in Chat  5 upvotes 9 months ago
      The conversation is about users trying to regain access to a Discord server related to pp405 research, with differing opinions on the effectiveness of pp405 for hair loss. Specific treatments like Minoxidil, finasteride, and RU58841 are not mentioned in the conversation.

      community Before you feel down about your hairloss

       28 upvotes 9 years ago
      Hair loss can be distressing, but treatments like finasteride, minoxidil, and scalp micropigmentation can help manage it. Embrace self-improvement, focus on personal goals, and maintain a positive attitude despite hair loss challenges.

      community Is PP405 actually different, or does it fall into the same pattern as previous treatments?

      in Research/Science 3 months ago
      PP405 is being discussed as a potential new approach to hair loss by targeting follicle stem cells, suggesting a different mechanism from existing treatments like finasteride and minoxidil. However, there is skepticism about whether it will lead to meaningful long-term outcomes or follow the pattern of previous treatments that showed promise but lacked consistent results.

      community Hot Take: Betting on PP405 can backfire

      in Research/Science  81 upvotes 1 year ago
      PP405 is seen as promising but uncertain, with users advised to continue using existing treatments like minoxidil and finasteride. Concerns include its cost, availability, and interaction with hair transplants, while some hope it could complement current treatments.

      community Since there is so much hype for cosmeRNA and HMI-115...

      in Chat  44 upvotes 3 years ago
      Exploring different treatments for hair loss, such as cosmeRNA and HMI-115 which are small interference messenger RNA that inhibits the DHT receptor and an antibody that binds to the prolactin (PRL) receptor respectively; and researching mechanism and environment of hyperresponders.

      community Bloodwork: what to test for?

      in Finasteride/Dutasteride  6 upvotes 5 years ago
      The user has been taking oral Finasteride and topical Essengen 6 Plus for hair loss and is experiencing increased depression. They plan to get bloodwork to check hormone levels and are seeking advice on which tests to include.

      community So I tried the natural approach and..

      in Chat  2 upvotes 11 months ago
      Natural DHT blockers caused negative side effects like weak erections and depression, while finasteride improved overall well-being and cleared acne. Users shared similar experiences, finding finasteride effective without the adverse effects of natural treatments.

      community PTD-DBM Update: Q&A With Dr. Kang-Yell Choi

      in Treatment  13 upvotes 6 years ago
      PTD-DBM is being explored for hair regrowth by targeting CXXC5, with clinical trials expected after pre-clinical studies. Users express anticipation and skepticism about its effectiveness.

      community No longer have drive in the gym

      in Chat  8 upvotes 2 months ago
      The user lost gym motivation after taking finasteride for four months, possibly due to its effect on DHT levels. Suggestions include adjusting dosage, trying topical treatments, using caffeine, checking testosterone levels, and considering supplements like SSRIs or pregnenolone.
      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 10 months ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

      community Im struggling with sebderm need help

      in Product  3 upvotes 3 months ago
      The user is struggling with seborrheic dermatitis and plans to try ciclopirox olamine after finding ketoconazole too drying. They are also using finasteride daily.

      community Reducing Fibrosis in Hair Loss: Topical Pirfenidone

      in Research/Science  58 upvotes 3 months ago
      Topical pirfenidone is highlighted as an effective anti-inflammatory and anti-fibrotic treatment for hair loss, particularly in addressing perifollicular fibrosis, which may enhance the effectiveness of standard treatments like finasteride and minoxidil. The user also uses calcipotriol, MCT oil, ciclopirox shampoo, and benzoyl peroxide shampoo as part of their regimen.

      community Discussion on Finasteride and life.

      in Chat  166 upvotes 1 year ago
      Finasteride can aid hair regrowth but may cause side effects like depression and sexual dysfunction. Users discuss experiences with finasteride, minoxidil, and RU58841, highlighting varied responses and the importance of informed treatment choices.

      community COQ10 + PQQ for scalp inflammation??

      in Chat  6 upvotes 2 years ago
      A 32-year-old male with diffuse thinning and seborrheic dermatitis has been using finasteride for 8 months without improvement. He is considering COQ10 + PQQ supplements for scalp inflammation and hair loss.

      community Any other non-responders to most medications?

      in Finasteride/Dutasteride  5 upvotes 2 years ago
      The user has not seen results from various hair loss treatments including finasteride, dutasteride, minoxidil, and others over several years and is considering adding RU58841 and starting hormone replacement therapy. They are also experiencing anxiety and contemplating moving to a more accepting environment for their nonbinary identity.

      community Ordered copper peptides - how to apply?

      in Treatment  1 upvotes 1 year ago
      Gizzela is unsure about the dosage and frequency of copper peptides and asks if they can be used with Stemoxydine. They seek advice on applying these treatments together.

      community People here just don't know what they are letting themselves in for!

      in Chat  122 upvotes 2 years ago
      The conversation discusses hair loss treatments, emphasizing the importance of patience and sticking with a treatment for at least 12-18 months before judging its effectiveness or adding new treatments. Users share experiences and agree that introducing treatments too quickly can lead to panic and negative outcomes.