community PTD-DBM Update: Q&A With Dr. Kang-Yell Choi
PTD-DBM is being explored for hair regrowth by targeting CXXC5, with clinical trials expected after pre-clinical studies. Users express anticipation and skepticism about its effectiveness.
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600-630 / 1000+ resultscommunity The dose dependent nature of the cardiac effects RU58841
Reducing the dose of RU58841 from 25mg to 7.5mg topically helped minimize heart palpitations. Users discussed the cardiac effects of RU58841 and minoxidil, noting that no treatment is completely free of side effects.
community Regression? Has anyone experienced this?
The user is experiencing increased hair shedding and is concerned about regression despite consistent use of finasteride, minoxidil, and other treatments. The consensus is that this is likely a temporary shedding phase, and adjustments to the dermarolling frequency are suggested.
community Has the user in the HMI-115 trial shared his photos now since it's April?
A user who was part of an ongoing trial for a prolactin blocker and had regrowth, but the progress photos were not shared due to negative reactions from other users. Treatments mentioned include HMI-115, Minoxidil, Finasteride, and RU58841.
community Acute shedding episodes. Had telogen effluvium last year. Remission for a few months(thought I was over the shedding stuff 🥲). Now if I have any major stress days, THAT day I get a major shed and a few days after.
The user experiences immediate hair shedding linked to stress, unlike typical telogen effluvium, and is seeking answers. A suggestion was made to use spironolactone and topical minoxidil to address potential DHT-related shedding.
community Progress(?) update photos 2.5 months of pyrilutamide and minoxidil
The conversation discusses hair regrowth progress after 2.5 months using pyrilutamide and minoxidil. Participants note visible improvement in a short time.
community 2 months Dutasteride - hyperresponder?
OP experienced significant hair growth after switching from topical treatments to oral Dutasteride, alongside using CJC/Ipamorelin and Cialis. They stopped using topical Minoxidil and Finasteride, attributing the hair growth to the new regimen.
community 2 years of oral fin, dut twice a week, one year of oral min, one month of pyripure - what do we think
The user has been using oral finasteride and minoxidil nightly, dutasteride twice a week, microneedling weekly, and pyripure nightly since April. They are seeking opinions on their hair regrowth progress, noting no slick bald areas but some miniaturized blonde hairs.
community Caffiene shampoos left in for 2 minutes show comparable results to Minoxidil, and may work differently than Minoxidil, which can add to your stack, or work for non responders
Caffeine shampoos show comparable results to Minoxidil and may enhance its effects when used together. Caffeine can be detected in the scalp up to 24 hours after a 2-minute application, making it an affordable treatment option.
community 2 years oral fin nonresponder, seeing regrowth in ~1 month from adding topical fin
After two years of no regrowth with oral finasteride and topical minoxidil, adding topical finasteride and dermastamping led to noticeable hair regrowth in one month. The combination of treatments, particularly the addition of topical finasteride and dermastamping, is believed to have improved absorption and effectiveness.
community Not only balding at a very young age but also not responding to the meds well.
A young person is experiencing aggressive hair loss and not responding well to minoxidil and finasteride. Suggestions include trying dutasteride, hair systems, lifestyle changes, or considering a wig.
community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found
The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.
community HLT Megathread on HMI-115 (key takeaways in comments)
HMI-115, a newly discovered hair loss treatment that could potentially be effective for those with diffuse thinning and telogen effluvium. It is based on prolactin receptor antagonist signaling and has already undergone Phase I trials in women, with potential commercialization by 2027.
community Fin bad responder? My experience
The user experienced side effects from ecklonia cava similar to those reported with finasteride, including depression, brain fog, anxiety, and testicular pain. Despite these issues, the user is still considering using topical finasteride in the future.
community Switching to oral minoxidil...
OP plans to switch from topical to oral minoxidil due to limited results and is advised to overlap both for a few weeks before discontinuing the topical. Oral minoxidil may be more effective for non-responders to topical treatment.
community for those who had high levels of testo and estradiol after start fin/dut: did it comeback to baseline or normal levels?
A user experienced increased testosterone and estradiol levels after starting finasteride/dutasteride and is asking if these levels will return to normal over time. The conversation focuses on whether these changes are temporary.
community Trichotest result says I am a non-responder to Fin? Should I switch to topical Dut?
The user experienced severe side effects with topical finasteride, continued using Minoxidil, and was advised to try topical dutasteride after a test suggested they might not respond to finasteride. They are hesitant to start the new treatment due to past side effects.
community Progress, 2nd shed and Drug resistance
User shares 8-month progress on oral finasteride and minoxidil, noting initial success followed by a second shed. They seek advice on drug resistance and pill efficacy, with responses suggesting to push through the shed and consider the impact of cycling off minoxidil.
community Ru58841 and later response (6+ months) ?
The user has tried many hair loss treatments including dutasteride, oral and topical minoxidil, topical finasteride, PRP, and microneedling without much success and is now using RU58841, seeing initial vellus hair growth but no further improvement after 5 months. They are inquiring about the effectiveness of RU58841 after 6-12 months of use.
community HT scheduled. Am I over reacting?
The user has scheduled a hair transplant after stabilizing hair loss with finasteride and minoxidil, considering additional dermarolling. They are advised to use 2500-3000 grafts conservatively for temple filling without lowering the hairline too much.
community Any positive responses for Diffuse Thinner with Retrograde using Fin/Min/Dut
People with diffuse thinning and retrograde hair loss are discussing treatments like finasteride, minoxidil, and dutasteride, with some reporting improvements and others experiencing issues like scalp inflammation and increased sebum. Suggestions include addressing scalp inflammation, considering gut health, and possibly using topical antiandrogens or micro-needling.
community Is there any progress? (2 months)
The conversation is about a user seeking feedback on hair regrowth progress after two months of using finasteride, minoxidil, ketoconazole shampoo, dermastamping, and iron supplements. Most responses suggest that two months is too early to see significant results and recommend patience, with noticeable changes typically occurring around 4-6 months.
community Weird response to microneedling
Microneedling can cause sneezing and eye tearing due to nerve stimulation, particularly near the temples and forehead. Some users find it lessens over time, while others prefer using finasteride and minoxidil for hair growth.
community Minaturization and recession accelerated on dutasteride but no shedding(19M)
A 19-year-old male is experiencing accelerated hair recession after two months on oral Dutasteride, despite no noticeable shedding, while also using topical Minoxidil and Finasteride. He is unsure if the treatment is effective and is unable to access RU58841.
community Beeezula off label (winlevi compounded)
User seeks availability of Breezula and its delayed trials. Asks for success with similar topical antiandrogens like fluridil.
community Pyrilutamide: Increased libido. Anyone else experienced something similar with either RU or Pyri?
An increase in libido associated with the use of Pyri, and a discussion about how it may be working comparably to other hair loss treatments such as RU58841, Finasteride and Minoxidil.
community I'm looking for treatment non-responders
The user has been using oral minoxidil, dutasteride, and RU58841 but continues to experience hair loss. They seek advice on why the treatments aren't working and if others have had similar experiences.
community great early results, then massive regression. Anyone experienced this?
The conversation discusses hair loss treatments, specifically finasteride, minoxidil, ketoconazole shampoo, and microneedling, with users experiencing initial success followed by increased shedding and regression. Many users suggest patience, as hair cycles can take years, and some attribute changes to seasonal shedding.
community For people who commented on my last post!! ( answering questions )
ShaneMorcs shared updated hair comparison photos and believes he's made progress. People commented on his improvement, asked about potential side effects, and inquired about the treatments he's using.
community 1 whole day of fin / min and NO results. Anyone else been through this??
A user humorously complains about not seeing immediate hair growth results after one day of using finasteride and minoxidil, even after microneedling. Replies include jokes and exaggerated experiences, with one user suggesting a satirical method of mixing and freezing the treatments.