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      community Pelage PP405 Phase 2a completed.

      in Research/Science  61 upvotes 4 months ago
      Minoxidil, finasteride, and RU58841 are discussed as treatments for hair loss, with excitement around a new drug, PP405, and a reformulated oral minoxidil in trials. Concerns about cost, side effects, and long-term use are also mentioned.

      community A Short Recap on PP405 and AAD 2026

      in Update 2 months ago
      PP405 is a promising experimental topical treatment for alopecia that reactivates dormant hair follicles by targeting cellular energy, with large-scale trials planned for 2026. While it shows potential, it cannot regenerate permanently destroyed follicles, making hair transplants the only guaranteed solution for advanced baldness currently.

      community New Study: PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and stimulate natural hair growth by 20%

      in Research/Science  842 upvotes 9 months ago
      PP405, developed by Pelage Pharmaceuticals, can reactivate dormant hair follicle stem cells and increase hair growth by 20% in eight weeks, unlike minoxidil or finasteride. However, skepticism remains about its effectiveness and availability, with concerns about funding and the timeline for broader access.

      community 14 Months Dut/Minox/Microneedling + 13 Months HRT

      in Transgender  36 upvotes 2 months ago
      The user shared their hair regrowth journey using treatments like dutasteride, minoxidil, microneedling, tretinoin, Nizoral, silica, biotin, and hormone replacement therapy (HRT) with cyproterone and estradiol. They reported substantial hairline improvement and some crown thinning, with hopes for further progress.

      community 5-Months Update: Minoxidil + Red Light Therapy + Lifestyle Changes

      in Progress Pictures  1031 upvotes 1 year ago
      The user reported positive hair regrowth after 5 months using Minoxidil, red light therapy, and lifestyle changes, including dietary improvements and stress reduction. They chose natural supplements like saw palmetto and beta-sitosterol over pharmaceutical DHT inhibitors like finasteride.

      community 6 months progress, topical Fin/Min

      in Is this regrowth?  152 upvotes 1 year ago
      The post discusses a user's 6-month progress using topical finasteride (0.08%) and minoxidil (5%) once a day, combined with scalp micropigmentation (SMP). The user hopes for improved hair growth as they let their hair grow out.

      community Am I microneedling right (only slight redness)?

      in Microneedling  7 upvotes 1 year ago
      Microneedling for hair regrowth, using a 1.0 dermastamp, is discussed with a focus on achieving slight redness without bleeding. Minoxidil is mentioned as an effective treatment when used after dermastamping.

      community Has anyone else seen this encouraging verteporfin case study?

      in Progress Pictures  35 upvotes 2 years ago
      The conversation discusses the potential use of verteporfin for hair loss treatment, with one user mentioning their surgeon's interest in trying it and another noting its research status and clinical use as a YAP inhibitor. Some users debate the market size, availability of generics, and the optimism in the hair loss community regarding new treatments.

      community Tropoelastin injections + verteporfin?

      in Research/Science  12 upvotes 3 years ago
      The use of tropoelastin injections and verteporfin for hair transplant recipients to help regrow donor area hairs, as well as research done on tropoelastin injections restoring elastin in scarred heart tissue and skin. There are discussions about why it is taking so long to get cosmetic mass produced tropoelastin injectables on the market.

      community 8 weeks in with microneedling and minoxidil/tretinoin

      in Progress Pictures  95 upvotes 1 year ago
      The user is using a combination of microneedling, minoxidil, tretinoin, scalp massages, and red light therapy to address hair loss, with a focus on the hairline and temples. They emphasize the importance of scalp massages and have seen regrowth, attributing success to their comprehensive routine.

      community South Korean Red Light Therapy Study

      in Research/Science  39 upvotes 3 months ago
      Korean scientists developed a red light therapy that reduces a hair loss marker by 92%. Users discussed the benefits and drawbacks of natural sunlight versus red light caps for hair health, with some suggesting supplements for vitamin D.

      community PRP ( PLATELET-RICH-PlASMA) for hair loss

      in Treatment  1 upvotes 2 years ago
      A 27-year-old male experiencing hair loss post-Covid is considering PRP (platelet-rich plasma) therapy. He's seeking personal experiences about the process, particularly regarding pain levels, despite his dermatologist's assurance of using local anesthesia.

      community Month 2.5 redo. Topical fin/min microneedling once a week.

      in Progress Pictures  18 upvotes 2 years ago
      A user who initially had positive results with oral finasteride, topical minoxidil, and microneedling for hair loss, but experienced side effects like fog and depression. After stopping and losing progress, they restarted with topical treatments and microneedling, reporting good results and no side effects.

      community 8 months of therapies, finasteride, minoxidil and more

      in Progress Pictures  397 upvotes 2 months ago
      The user experienced significant hair regrowth over 8 months using finasteride, minoxidil, and a custom topical mix including progesterone, cortisone, and alpha 5 estradiol. They reported no side effects and noticed improvement around the third month.

      community New Light Therapy Can Suppress a Key Marker of Hair Loss by 92%

      in Research/Science  201 upvotes 2 months ago
      A new light therapy claims to reduce hair loss markers by 92% using a specific wavelength range. Users discuss the cost and effectiveness of devices, with some expressing skepticism and others considering alternative treatments like red light therapy and vitamin D exposure.
      PP405 Identity Research

      community PP405 Identity Research

      in Research  292 upvotes 10 months ago
      PP405 is a potential hair loss treatment that inhibits mitochondrial pyruvate carriers, increasing lactate dehydrogenase activity and stimulating hair follicle stem cells. In a phase 1 trial, 31% of participants showed over 20% hair density increase with PP405 treatment.

      community Here is my hair regrowth plan

      in Treatment  4 upvotes 5 years ago
      The user's hair regrowth plan includes topical treatments (RU58841, azelaic acid, ketoconazole), oral supplements (Gia Herbs, castor oil), microneedling, PTD-DBM peptide with valproic acid, red light therapy, inversion table with scalp massage, and platelet-rich fibrin injections. Commenters suggest that finasteride and minoxidil are essential treatments for male pattern hair loss, which are missing from the plan.

      community where and how to do Verteporfin after HT

      in Transplants  4 upvotes 2 years ago
      The conversation is about a user planning to undergo a hair transplant and seeking information on clinics that perform Verteporfin treatment. A user suggests Dr. Barghouthi might offer this service.

      community Quote from Pelage (PP-405) Spokesperson...

      in Research/Science  122 upvotes 8 months ago
      Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

      community Stimulating existing stem cells to grow hair.

      in Technology  119 upvotes 3 years ago
      Hair regrowth treatments, including stem cell injections, are discussed, with skepticism about their effectiveness compared to Minoxidil and finasteride. Derma stamping is mentioned as effective when used with Minoxidil, finasteride, and dutasteride.