The conversation is about using topical finasteride for hair loss and concerns about its application, sideeffects, and practicality. Users suggest switching to oral finasteride for convenience, despite potential sideeffects.
People discussed their experiences with anti-androgens for hair loss, mentioning sideeffects like chest pains with RU58841 and skepticism due to lack of safety data, while considering Fluridil as a potential addition to treatment. Some users expressed reluctance to use these chemicals.
Clascoterone (CB) shows an excellent safety profile with no serious sideeffects, but its effectiveness may decline after six months, making it more suitable as an adjunct treatment with finasteride and minoxidil rather than a standalone solution. Some argue it could be better than finasteride due to its protection against testosterone, but its long-term efficacy remains debated.
The user experienced chest soreness and mild gynecomastia after taking 1mg finasteride three times a week, which resolved after stopping the medication. They are considering trying a lower dose or topical finasteride to avoid sideeffects.
Finasteride may take over two years to show results and can cause sideeffects like sexual dysfunction and emotional changes. Alternatives such as dutasteride and minoxidil are discussed, with varying effectiveness and sideeffects.
The user started oral minoxidil (2.5mg) and finasteride (1.25mg) for hair loss but experienced decreased libido, weaker erections, and sleep issues after a week. They stopped finasteride and are considering lowering the dosage due to concerns about sideeffects.
User asks if spironolactone can stack with finasteride and pyrilutamide for hair loss treatment. They question why spironolactone is associated with feminizing effects, while RU/pyri/fluridil, which work similarly, are not.
RU58841 lacks FDA approval due to financial and safety concerns, including potential cardiological sideeffects. The company abandoned further research, and users report adverse effects like heart palpitations and gynecomastia.
The conversation discusses managing estradiol problems during finasteride treatment. Suggestions include stopping finasteride every 3 months for 2-3 weeks or reducing the dosage.
A user has been taking finasteride 1mg for 10 years without sideeffects but is concerned about high estradiol levels affecting weight loss. Another user suggests using estradiol blockers under medical supervision to manage the levels.
Akinfenrawr experienced negative sideeffects from oral finasteride and RU58841, and is seeking alternative hair loss treatments. They discuss various options, including raloxifene, oral dutasteride, liposomal finasteride, Breezula, Pyrilutamide, SM04554, and sulforaphane, but have concerns about efficacy, availability, and cost.
Finasteride can cause sleep disturbances, but these often improve over time. Some users experience sideeffects like reduced libido and brain fog, while others see hair regrowth and manage sideeffects by adjusting dosage or switching to topical treatments.
The conversation discusses the absorption and effectiveness of PG-free versus PG versions of RU58841, with some users believing PG improves efficacy while others see no difference. Concerns about RU58841's potential sideeffects on the endocrine system are also mentioned, with one user considering switching to pyrilutamide.
Dutasteride treatment may decrease sperm concentration, but levels remain above WHO recommendations and recover after discontinuation. The study has limitations, including small sample size and lack of pre-treatment sperm data, and does not assess other fertility factors.
The user stopped finasteride for family planning but plans to restart it and is considering dutasteride. Users discuss the safety of finasteride during family planning, with some sharing experiences of having healthy children while on the medication.
The user has been using finasteride for hair loss and is considering adding RU58841. They ask about RU58841's effectiveness, potential heart sideeffects, duration of action, dosage increase over time, transitioning to GT20029, and where to find the liquid form.
OP is considering Bicalutamide for female AGA and TE but is concerned about its sideeffects and effectiveness compared to Finasteride. OP is also using Minoxidil and Spironolactone but is experiencing significant shedding and is unsure if it's androgen-driven or due to Minoxidil changes.
Finasteride has no effect on the user's estradiol levels, and body fat may influence aromatization. The user is on testosterone replacement therapy and uses everyday injections to manage high RBC count, with plans to measure DHT, DHEA-S, and pregnenolone levels.
White rice may lower DHT and potentially cause symptoms similar to post-finasteride syndrome. The user experienced muscle wasting, depression, and other symptoms after consuming large amounts of white rice.
A user considered restarting finasteride for hair loss despite past sideeffects, which worried their girlfriend. Others suggested alternatives like topical treatments or lower doses and emphasized prioritizing well-being and relationship stability.
RU58841 had mixed results for hair regrowth, with some users experiencing no change and others noting regrowth but also sideeffects like libido issues and chest pain. Some users combined it with other treatments like finasteride and dutasteride, with varying effectiveness.
The user is experiencing hair loss despite using finasteride three times a week due to sideeffects and is considering alternatives like topical finasteride, estrogen blockers, or dutasteride. They are also interested in potential treatments like GT20029 and pyrilutamide.
A user is considering switching from oral to topical treatments for hair loss due to sideeffects like watery semen and erectile dysfunction. They are currently using oral finasteride and minoxidil and are concerned about potential sexual sideeffects with topical use.
Low estrogen levels may reduce the risk of sideeffects from finasteride, such as gynecomastia. Some users plan to start with microneedling and minoxidil before trying finasteride, while others have experienced temporary sideeffects from topical finasteride but continued use without persistent issues.
Pregnancy can temporarily reverse hair loss in women, but attempts to mimic pregnancy hormones with treatments like contraceptive pills, spironolactone, estradiol, progesterone, finasteride, and minoxidil have been ineffective. The discussion highlights the need for research into the hormonal mechanisms of pregnancy that affect hair regrowth.
Some people have sideeffects from finasteride and dutasteride due to hormonal predisposition, especially if DHT dominant. Alternatives like RU58841, Pyrilutamide, and Breezula are suggested to target scalp androgen receptors without altering overall hormones.
Stopping finasteride increased sex drive and improved mood but caused hair shedding and scalp irritation. Users discussed balancing hair preservation with sideeffects, considering alternatives like topical finasteride and minoxidil.
The user replaced finasteride with saw palmetto due to availability issues and experienced sideeffects, leading to adjustments in their regimen. They use saw palmetto, minoxidil, Nizoral, and a dermaroller, reporting reduced sideeffects and some benefits, with hair fall ranging from 5 to 20 hairs daily.
The user experienced gynecomastia from finasteride, used raloxifene to treat it, and is now taking both without new gyno symptoms but also without hair regrowth. They are seeking others' experiences with this combination and its effects on hair.