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community Approve PP405 quickly you coward

in Satire 193 upvotes 10 months ago

Pelage Pharmaceuticals is developing PP405, a topical treatment for hair growth, currently in Phase 2a trials. There is skepticism about the company's claims, and no fast-tracking approval timeline has been detailed.

community ”Why are we not funding this?” - Peter Griffin

in Finasteride/Dutasteride 220 upvotes 10 months ago

Topical finasteride can reduce scalp DHT as effectively as oral finasteride with fewer systemic effects, but availability is limited. Some users make their own solutions due to limited access.

community How much Minoxidil goes systemic?

in Basic Questions 93 upvotes 10 months ago

The conversation is about the systemic absorption of Minoxidil and the potential switch from topical to oral Minoxidil due to its effectiveness. The user considers oral Minoxidil after experiencing no side effects from a year of using 15% topical Minoxidil.

community How do you actually "apply" topical minoxidil?

in Minoxidil 29 upvotes 10 months ago

The conversation discusses various methods for applying topical minoxidil to the scalp, including using fingers, a shoe polish bottle, a dropper, a toothbrush, a q-tip, a makeup brush, and a syringe. Users emphasize the importance of massaging the product into the scalp for better absorption.

community Low Testosterone after taking finastreide

in Finasteride 45 upvotes 10 months ago

A 19-year-old experienced significantly low testosterone levels after one month of taking finasteride. Suggestions included checking test units, retesting, and exploring other potential causes.

community UPDATE: now 5 months on Dut and continuing to regress aggressively

in Finasteride/Dutasteride 218 upvotes 10 months ago

The user is experiencing significant hair loss after switching from finasteride to dutasteride for five months. Suggestions include that the hair loss might be a normal shedding phase, with some recommending continuing the treatment for up to 24 months or considering alternatives like RU58841.

community Successfuly combating gynocomastia with an extremly low dose of topical Tamoxifen

in Treatment 11 upvotes 10 months ago

Using a low dose of topical Tamoxifen effectively reduces gynecomastia caused by finasteride, with minimal side effects. The solution involves mixing Tamoxifen with ethanol and propylene glycol, applied daily to the chest.

community Hot Take: Betting on PP405 can backfire

in Research/Science 83 upvotes 10 months ago

PP405 is seen as promising but uncertain, with users advised to continue using existing treatments like minoxidil and finasteride. Concerns include its cost, availability, and interaction with hair transplants, while some hope it could complement current treatments.

community 1.25 mg Fin for a year, and very inconsistent oral min for 3 months.

in Progress Pictures 156 upvotes 10 months ago

The user experienced significant hair regrowth using 1.25 mg finasteride daily and inconsistent oral minoxidil, with no side effects reported. Finasteride primarily increased hair density, while minoxidil contributed to thicker, healthier hair.

community Will PP405 render Minox and Fin obsolete?

in Research/Science 26 upvotes 10 months ago

PP405 might make minoxidil unnecessary, but finasteride or other 5AR inhibitors may still be needed. PP405 is expected to be expensive and not available until at least 2028, with limited information on its effectiveness.

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