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      community RU58841 in Pumpkin Seed Oil (PSO)

      in Treatment  4 upvotes 2 years ago
      A user is seeing good results with RU58841 for hair loss, noting reduced shedding and thicker hair. They plan to use pumpkin seed oil as a solvent to avoid water content, which they believe reduces the effectiveness of anti-androgens.

      community Pili migrans? Lichen something? Seb derm?

      in Female  19 upvotes 1 year ago
      The conversation is about a female experiencing hair loss and seeking advice on why it's difficult to regrow hair. Specific treatments like Minoxidil, finasteride, or RU58841 are not mentioned.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Went from almost balding to some this!

      in Progress Pictures  498 upvotes 2 years ago
      A user successfully regrew hair after nearly going bald by using oral finasteride, topical minoxidil, plasma injections, and mesotherapy over 9 months. They plan to try derma rolling and have an alarm set for taking medication, noting increased sexual drive as a side effect.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community 4 Month Progress, 34 M- Minoxidil 5%+ Finasteride .2% liquid + Tretinoin 0.01% liquid - Once a day + Dermaroller once a week. Picture in the comments as well.

      in Is this regrowth?  40 upvotes 1 month ago
      A 34-year-old male shares his 4-month progress using Minoxidil 5%, Finasteride 0.2% liquid, Tretinoin 0.01% liquid, and a dermaroller once a week for hair regrowth, reporting no side effects and noticing baby hairs on the crown. He prefers topical treatments over oral Finasteride and is optimistic about further progress.

      community How common is serious regrowth for people 35yrs old and up?

      in Finasteride/Dutasteride  20 upvotes 9 months ago
      Regrowth is more likely if hair follicles are still alive, regardless of age, but younger individuals often see better results due to early intervention. Treatments like finasteride, minoxidil, and dermarolling can help, but results vary based on individual factors such as the presence of miniaturized hairs and the speed of treatment initiation.

      community My hairloss stack, progress pics soon maybe for 1 year RU

      in Technology  49 upvotes 3 years ago
      The conversation is about a user's hair loss treatment routine, which includes RU58841 for 9 months and Dutasteride for 6 months, with other unspecified treatments considered extra. One user inquired about the source of RU58841.

      community Pelage are starting phase 3 for PP405 towards the end of 2026

      in Chat  180 upvotes 4 months ago
      PP405 is moving to late-stage trials, showing potential for hair regrowth, with 31% of male patients experiencing a 20% increase in hair density. Veradermics is developing an oral minoxidil version, and there is interest in combining treatments for better results.

      community Thoughts on this 2-deoxy-D-ribose Topical?

      in Treatment  27 upvotes 1 year ago
      The post and conversation are about skepticism towards a new hair loss treatment containing 2-deoxy-D-ribose, copper peptides, and exosomes, with concerns about the legitimacy of the product and its website. The treatment's effectiveness and authenticity are questioned due to lack of testing and transparency.

      community What Norwood would you guys say I’m at?

      in Satire  208 upvotes 7 months ago
      The conversation humorously discusses hair loss and potential treatments like finasteride and minoxidil. It includes playful banter and jokes about appearance and identity.

      community the ordinary retinol & minoxidil

      in Minoxidil  13 upvotes 1 year ago
      Using retinol with minoxidil may not be as effective as tretinoin, but retinaldehyde or adapalene could be alternatives. A micro-roller with minoxidil is suggested for better results.

      community Insane regression after hyper-responding (17M) AMA

      in Progress Pictures  137 upvotes 1 year ago
      A 17-year-old experienced significant hair loss after switching from topical to oral minoxidil and adding finasteride. The recommendation is to return to topical minoxidil and continue with finasteride or consider dutasteride.

      community October 2024 - Jan 2025 4 months

      in Progress Pictures  32 upvotes 1 year ago
      The user experienced hair regrowth using topical finasteride 1% and minoxidil 5% over four months, with no side effects and improved hair density. They initially experienced shedding, which was followed by regrowth, and they stopped dermarolling due to concerns about damaging new growth.

      community RU58841 and impact onmale fertility?

      in Chat  2 upvotes 2 years ago
      The conversation is about the potential impact of RU58841 on male fertility, specifically regarding sperm concentration, total count, and motility. The user is curious about the likelihood of RU58841 reducing fertility based on its mechanism of action and comparisons to similar substances.

      community Watching my younger brother bald hurts so much.

      in Treatment  268 upvotes 1 year ago
      A 19-year-old is distressed about his 17-year-old autistic brother's hair loss, projecting his own insecurities despite being on finasteride and dutasteride. Replies suggest the brother might not care about balding, and the poster should address his own issues.

      community 2 Months oral Min/Fin/dermarolling

      in Is this regrowth?  28 upvotes 9 months ago
      The user has been using oral Minoxidil, Finasteride, and dermarolling for two months to address hair loss and is considering continuing the treatment until December before possibly switching to Dutasteride. They are hesitant about getting a hair transplant and are exploring other options like SMP, while receiving encouragement and advice from others to continue the current regimen for a longer period to see more results.

      community Best available SARD right now?

      in Treatment  3 upvotes 2 months ago
      The user is considering RU58841 and has been using dutasteride since age 17. They are seeking affordable SARD options, mentioning ASC-J9, GT20029, and AH001.

      community Balding without a family history

      in Chat  6 upvotes 7 months ago
      The user is experiencing hair loss without a family history and suspects stress or telogen effluvium (TE) as the cause, despite using finasteride without results. Others suggest stress, vitamin deficiencies, or other conditions could be factors, and some mention that balding can occur without a family history.