Search

for
Search:

GlossaryRSPO3

protein involved in hair follicle development and regeneration

RSPO3 stands for R-spondin 3, a protein that plays a crucial role in the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, RSPO3 is involved in the regulation of hair follicle development and regeneration, making it a significant factor in understanding conditions like alopecia.

Related Terms

Sort by

Community Join

30 / 1000+ results

community REVOLUTION in AUGUST: New possibilities according to Dr. Muñoz (pinacidil, cromakalim, diazoxide and nicorandil)

in Technology 13 upvotes 9 months ago

Dr. Muñoz's discovery suggests that targeting potassium channels in fibroblasts could reactivate hair growth, offering new treatment possibilities for alopecia. Potential strategies include using minoxidil, diazoxide, and other potassium channel openers, as well as bioelectric devices and direct growth factor applications.

community A warning to anyone considering 3rd party sourcing PP405 or its analogs

in Treatment 31 upvotes 2 months ago

Be cautious when sourcing PP405 or its analogs from third-party suppliers due to potential safety risks and lack of regulatory approval. The conversation highlights concerns about counterfeit products and the absence of reliable testing, making it risky to use such treatments.

community 9 months big 3, 46 y/o. Adding RU

in Progress Pictures 45 upvotes 2 years ago

The person is using 1mg of finasteride daily, 2mg of minoxidil, and weekly dermarolling with a 1mm needle. They sometimes use topical minoxidil as well.

community Just ordered RU powder, a scale, beaker, ethanol and PG. This will be my final attempt.

in Treatment 7 upvotes 3 years ago

The user is trying RU58841, oral minoxidil, and dermarolling to combat hair loss caused by increased scalp testosterone after using finasteride and dutasteride. They plan to document their results.

community Funding for sending RU58841 from rudirect.co.uk to Janoshik Analytical

in Research/Science 11 upvotes 1 year ago

The conversation is about a user trying to fund lab testing for RU58841 to verify its legitimacy, as there are doubts about its effectiveness. Some users express skepticism about RU58841, suggesting alternatives like KX-826.

community 3 month progress pictures RU fin and OM

in Progress Pictures 42 upvotes 2 years ago

The user shared progress pictures after three months of using RU58841, finasteride, and OM (oxidative stress modulators) for hair loss treatment. They haven't noticed much change but are seeking feedback on their results.

community Why there are no updates from Amplifica about SCUBE3 & AMP-303?

in Research/Science 6 upvotes 8 months ago

Amplifica has not provided updates on SCUBE3 and AMP-303, raising concerns about their trial outcomes. Users also mention other treatments like Minoxidil, finasteride, RU58841, PP405, and ET-03.

community How’s RCH-01 doing?

in Treatment 6 upvotes 6 years ago

RCH-01's progress is uncertain, and there's skepticism about its effectiveness. Users are losing hope in this treatment.

community Anyone else a non-responder to spiro?

in Treatments 63 upvotes 1 year ago

The conversation discusses hair loss treatments, specifically mentioning Spiro, Min, Fin, and RU. It highlights that Spiro is generally for women and can affect men's hormonal balance.

community SUBE3 for sale in the gray market?

in Chat 4 upvotes 1 year ago

SCUBE3 is available online but poses risks like tumor promotion and high costs. Users advise against using it due to health concerns and inefficacy as a standalone treatment.

community Rejected for the 2nd time for the VDPHL01 Clinical Trials (believe it or not!)

in Chat 12 upvotes 1 year ago

The user was rejected from participating in a clinical trial for an extended-release oral Minoxidil due to having rheumatoid arthritis, despite initially being accepted. They had stopped using Dutasteride and Minoxidil to qualify but continued using other treatments like RU58841 and red light therapy.

community Breezula phase 3 results said to be released next month

in Product 27 upvotes 1 year ago

Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.

community Trial for TDM-105795 update from research office

in Research/Science 17 upvotes 2 years ago

The trial for TDM-105795 has been completed, and it was in phase 2A. The discussion seeks input on the next phases, 2B or 3, based on safety and efficacy.

community Nice & pure PRP, 3 ml of this is going to the scalp.

in Research/Science 32 upvotes 3 years ago

The use of PRP to treat hair loss and its potential effectiveness when combined with 5 alpha reductase blockers such as Minoxidil or Finasteride.

community Pelage have presented only phase 2a. The rest of phase 2 for PP405 will be presented at a later medical meeting

in Chat 30 upvotes 2 months ago

PP405's phase 2a trial results were presented, focusing on safety and pharmacokinetics, with a future meeting planned to share the full dataset. The trial includes a randomized controlled portion and an open-label extension, with no indication of phase 2B completion.

community Spiro for AGA in Europe

5 upvotes 6 years ago

Treatment options for female alopecia androgenetica, discussing the availability of spironolactone online in The Netherlands and other potential treatments like finasteride, minoxidil and RU58841.

community Switching RU vehicle due to scalp irritation – anyone tried low-EtOH + squalane / emu oil?

in Treatment 2 upvotes 6 months ago

The user is experiencing scalp irritation from using RU58841 with a 70% ethanol and 30% propylene glycol vehicle and is considering switching to a less irritating vehicle, such as 30% ethanol with 70% squalane or emu oil. They are seeking feedback on the effectiveness and irritation levels of these alternative carriers.

community PCOS female who posted before; saw Endo today. prescribed spironolactone and minox 5%

in Update 1 upvotes 3 years ago

PCOS female visited doctor for hair loss concerns, prescribed spironolactone and minox 5%. Doctor advised against finasteride or dutasteride, user considering self-medication with dutasteride.

community PP405 (Everychem 3HP) Anecdotes - Please assemble and share your story

in Chat 107 upvotes 2 months ago

PP405 (Everychem 3HP) may help with hair regrowth, with mixed user experiences. Users often combine it with minoxidil and finasteride, but there are concerns about its efficacy and side effects.

community How would you react if PP405 isn't successful in phase 3 trials?

in Chat 23 upvotes 6 months ago

People are discussing their reactions if PP405 fails in phase 3 trials, with some expressing skepticism and others holding onto hope for future treatments like GT20029 and Breezula. Many mention continuing with existing treatments like minoxidil and finasteride, while others express disappointment and consider alternative solutions.

community PP405 2a study was a safety study. Some rational explaining.

in Research/Science 22 upvotes 9 months ago

The conversation discusses the safety study of PP405, emphasizing that early trials focus on safety rather than efficacy, and that any efficacy data from such a short study should be viewed skeptically. It also highlights that the information released is primarily for securing funding, and that meaningful efficacy results are expected in later phases.

community How to mix ru-powder with European ingredients?

in Product 1 upvotes 2 years ago

A user seeks advice on mixing RU58841 serum using European ingredients, specifically struggling to find propylene glycol. They are looking for alternatives to American products commonly recommended in guides.

community PP405 (Non) Update - Feb 2025

in Research/Science 34 upvotes 1 year ago

The conversation discusses the delay in the PP405 Phase 2 study results, now expected by the end of 2025, and skepticism about research practices. There is also mention of optimism for Amplifica's AMP303 and a topical treatment in early testing.

community Question about making a solution of RU58841

in Treatment 1 upvotes 3 years ago

The conversation is about making a solution of RU58841 using propanediol instead of propylene glycol due to skin irritation. The user seeks advice on whether this substitution is acceptable.

community Big 3 + dermaroller update

213 upvotes 7 years ago

A user's experience with the Big 3 (minoxidil, finasteride and RU58841) hair loss treatment along with dermarolling. The dermaroller pin was 1.5mm used once per week and drew some blood but not a lot.

community Why doesn't phase 3 of PP405 start straight away?

in Chat 14 upvotes 5 months ago

Pelage is delaying the start of phase 3 trials for PP405 to 2026 due to necessary regulatory processes, despite having $120 million in funding. Users discuss the potential of PP405 for hair regrowth, with some expressing skepticism and others hopeful for new treatments like Breezula.

community Ru with gloves because of Systemic absorption?

in Research/Science 10 upvotes 2 years ago

The conversation is about whether to use gloves when applying 5% RU58841 to avoid systemic absorption and if washing hands with water is sufficient. Users question the concern, noting it is applied to the scalp.

community Pp405 any site for buying in Europe

in Product 1 month ago

PP405 is not commercially available or legitimate in Europe. Users are discussing the lack of availability of this product.

community RU-58441 Janoshik test result of Made-In-China Supplier

in Product 27 upvotes 6 months ago

A user ordered RU58841 from a Chinese supplier, found it to be less than 99% pure, and plans to try a different seller next time. Concerns were raised about impurities, but the user believes they are likely inactive fillers rather than harmful substances.

community Considering 75mg oral spiro for hairloss (man)

in Treatment 3 years ago

Hair loss treatments Fin and Minoxidil failed for user. Suggested alternatives are 75mg oral spiro and RU58841, but concerns about low testosterone and self-esteem were raised.